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1.
Prenat Diagn ; 43(13): 1614-1621, 2023 12.
Artículo en Inglés | MEDLINE | ID: mdl-37940634

RESUMEN

OBJECTIVE: To demonstrate the feasibility and preliminary results of percutaneous fetal endoscopic third ventriculostomy (ETV) in human fetuses (pfETV) with isolated progressive and/or severe bilateral cerebral ventriculomegaly (IPSBV). METHODS: The initial results of pfETV for IPSBV were described. Perioperative, perinatal and postnatal variables were described. The Ages and Stages Questionnaire (ASQ-3), 3rd edition (ASQ-3) was used for follow-up of all infants. RESULTS: Successful pfETV was performed in 10/11 (91%) fetuses, at a median gestational age (GA) of 28.7 weeks (25.3-30.7). There were no perioperative complications. After pfETV, 70% (7/10) of the fetuses had a decreased or stabilized lateral ventricle atria|lateral ventricle's atria. The median GA at delivery was 38.2 weeks (35.9-39.3). There were no perinatal complications. The postnatal ventriculoperitoneal shunt rate was 80% (8/10). Among neonates/infants who had prenatal stabilization or a decrease in the LVAs, 4 (4/7: 57.1%) had abnormal scores on the ASQ-3. Among neonates/infants that experienced prenatal increases in the LVAs, all of them (3/3: 100%) had abnormal scores on the ASQ-3. CONCLUSION: Percutaneous ETV is feasible in human fetuses with progressive and/or severe cerebral ventriculomegaly and seems to be a safe procedure for both the mother and the fetus.


Asunto(s)
Hidrocefalia , Tercer Ventrículo , Lactante , Recién Nacido , Embarazo , Femenino , Humanos , Ventriculostomía/efectos adversos , Ventriculostomía/métodos , Tercer Ventrículo/diagnóstico por imagen , Tercer Ventrículo/cirugía , Estudios Retrospectivos , Hidrocefalia/diagnóstico por imagen , Hidrocefalia/cirugía , Hidrocefalia/complicaciones , Feto/cirugía , Resultado del Tratamiento
2.
Prenat Diagn ; 41(13): 1634-1642, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-34583428

RESUMEN

OBJECTIVE: To analyze the impact of gestational age (GA) at the time of fetal open spinal dysraphism (OSD) repair through a mini-hysterotomy on the ability of children to walk. METHODS: Children who underwent in utero repair of OSD and had formal neurological assessment after 2.5 years of age were compared regarding their ability to walk in relation to pre-surgical predictors. RESULTS: Sixty-nine children fulfilled the inclusion criteria. Among them, 63.7% (44/69) were able to walk with or without orthesis. Fetal OSD correction performed earlier in gestation (from 19.7 to 26.9 weeks) was associated with a higher probability of walking with or without orthesis (p = 0.033). The median GA at delivery was 35.3 weeks. Multivariate binary logistic regression showed that the upper anatomical level of the OSD ( L5) (p < 0.004; OR: 10.31 [95% CI: 2.07-51.28]) and GA at the time of fetal surgery (p = 0.026; OR = 0.68 [95% CI: 0.48-0.95]) were independent predictors of the postnatal ability to walk with or without orthesis. CONCLUSION: Fetuses with OSD who were operated on earlier in pregnancy (range: 19.7-26.9 weeks), were more likely to walk with or without orthesis.


Asunto(s)
Edad Gestacional , Histerectomía/normas , Disrafia Espinal/cirugía , Caminata/estadística & datos numéricos , Adulto , Niño , Femenino , Terapias Fetales/métodos , Terapias Fetales/normas , Terapias Fetales/estadística & datos numéricos , Humanos , Histerectomía/métodos , Histerectomía/estadística & datos numéricos , Embarazo , Estudios Retrospectivos , Disrafia Espinal/complicaciones
3.
Prenat Diagn ; 40(6): 689-697, 2020 05.
Artículo en Inglés | MEDLINE | ID: mdl-32112579

RESUMEN

OBJECTIVE: To analyze the impact of gestational age (GA) at the time of fetal open spinal dysraphism (OSD) repair through a mini-hysterotomy on the perinatal outcomes and the infants' ventriculoperitoneal shunt rates. METHODS: Retrospective study of cases of fetal OSD correction performed from 2014 and 2019. RESULTS: One hundred and ninety women underwent fetal surgery for OSD through a mini-hysterotomy, and 176 (176/190:92.6%) have since delivered. Fetal OSD correction performed earlier in the gestational period, ranging from 19.7 to 26.9 weeks, was associated with lower rates of postnatal ventriculoperitoneal shunting (P: .049). Earlier fetal surgeries were associated with shorter surgical times (P: .01), smaller hysterotomy lengths (P < .001), higher frequencies of hindbrain herniation reversal (P: .003), and longer latencies from surgery to delivery (P < .001). Median GA at delivery was 35.3 weeks. Multivariate binary logistic regression showed that both fetal lateral ventricle-to-hemisphere ratio (%; P < .001; OR: 1.14 [95% CI: 1.09-1.21]) and GA at the time of fetal surgery (P: .016; OR: 1.37 [95% CI: 1.07-1.77]) were independent predictors of postnatal ventriculoperitoneal shunting. CONCLUSION: Fetuses with OSD who were operated on earlier in the gestational interval, which ranged from 19.7 to 26.9 weeks, were less prone to receiving postnatal ventriculoperitoneal shunts.


Asunto(s)
Terapias Fetales/métodos , Edad Gestacional , Procedimientos Neuroquirúrgicos/métodos , Espina Bífida Quística/cirugía , Derivación Ventriculoperitoneal/estadística & datos numéricos , Adolescente , Adulto , Malformación de Arnold-Chiari/complicaciones , Malformación de Arnold-Chiari/diagnóstico por imagen , Femenino , Humanos , Histerotomía/métodos , Recién Nacido , Masculino , Persona de Mediana Edad , Embarazo , Espina Bífida Quística/complicaciones , Espina Bífida Quística/diagnóstico por imagen , Resultado del Tratamiento , Adulto Joven
4.
Fetal Diagn Ther ; 42(1): 28-34, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-27656888

RESUMEN

OBJECTIVE: To present the feasibility of fetal myelomeningocele (MMC) repair through a mini-hysterotomy and to describe the perinatal results from our initial experience. METHODS: A descriptive study of cases of fetal MMC correction via mini-hysterotomy performed between 2014 and 2016. RESULTS: Forty-five women underwent fetal surgery and 87% (39/45) delivered. A complete multilayer correction of the MMC was possible in all cases. There were no maternal, fetal or neonatal deaths. No maternal or fetal complications occurred from fetal MMC correction until maternal hospital discharge. The average gestational age (GA) at surgery was 24.5 weeks (standard deviation, SD: 1.7; range: 20.7-26.9). The median hysterotomy length was 3.05 cm (SD: 0.39; range: 2.50-3.50). One patient (1/39; 2.6%) experienced chorioamniotic separation. Nine patients (9/39; 23.1%) had premature preterm rupture of membranes at a median GA of 34.1 weeks (range: 31.1-36.0). The average GA at delivery was 35.3 weeks (SD: 2.2; range: 27.9-39.1). Ninety-five percent (37/39) of our patients had an intact hysterotomy site at delivery. Ventriculoperitoneal shunt placement was necessary for 7.7% (3/39) of the neonates. CONCLUSION: Fetal MMC repair is feasible through a mini-hysterotomy. This approach appears to be associated with reduced risks of very preterm delivery and maternal, fetal and neonatal complications.


Asunto(s)
Histerotomía/efectos adversos , Meningomielocele/cirugía , Complicaciones Posoperatorias/prevención & control , Adulto , Malformación de Arnold-Chiari/etiología , Malformación de Arnold-Chiari/prevención & control , Brasil/epidemiología , Estudios de Factibilidad , Femenino , Rotura Prematura de Membranas Fetales/epidemiología , Rotura Prematura de Membranas Fetales/etiología , Rotura Prematura de Membranas Fetales/prevención & control , Estudios de Seguimiento , Edad Gestacional , Humanos , Hidrocefalia/etiología , Hidrocefalia/prevención & control , Hidrocefalia/cirugía , Incidencia , Recién Nacido , Masculino , Meningomielocele/embriología , Meningomielocele/fisiopatología , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Embarazo , Segundo Trimestre del Embarazo , Nacimiento Prematuro/epidemiología , Nacimiento Prematuro/etiología , Nacimiento Prematuro/prevención & control , Riesgo , Derivación Ventriculoperitoneal/efectos adversos
5.
Childs Nerv Syst ; 26(11): 1555-61, 2010 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-20461522

RESUMEN

OBJECT: The aim of this study is to evaluate the outcome of young children hospitalized for non-accidental head trauma in our PICU, to evaluate PRISM II score in this sub-population of pediatric trauma and to identify factors that might influence the short-term outcome. MATERIALS AND METHODS: Files of all children less than 2 years old with the diagnosis of non-accidental head trauma over a 10-years period were systematically reviewed. We collected data on demographic information, medical history, clinical status, and management in the PICU. Three severity scores were then calculated: PRISM II, Glasgow Coma Scale (GCS), and Pediatric Trauma Score (PTS). Prognosis value of qualitative variables was tested with a univariate procedure analysis (anemia, diabetes insipidus...). Then, quantitative variables were tested with univariate procedure too (age, weight, PRISM II, GCS, Platelet count, fibrin, prothrombin time (PT)...). Potential association between variables and death was tested using univariate procedure. Variables identified by univariate analysis were then analyzed with multivariate analysis through a forward-stepping logistic regression. RESULTS: Thirty-six children were included. Mean age was 5.5 months (8 days-21.5 months). Mortality rate was 27.8%. At admission, PTS, PRISM II, GCS, PT, PTT, and diabetes insipidus were significantly altered or more frequent in non survivors. Cutoff value for PRISM II at which risk of mortality increased was 17.5 (sensitivity = 0.8; specificity = 0.88). CONCLUSION: PRISM II is a reliable and easy performing tool for assessing the prognosis of non-accidental cranial traumatism in young children. GCS and PTS, scores even simpler than PRISM II, showed good accuracy regarding survival prediction.


Asunto(s)
Síndrome del Niño Maltratado/diagnóstico , Daño Encefálico Crónico/diagnóstico , Lesiones Encefálicas/diagnóstico , Maltrato a los Niños/diagnóstico , Síndrome del Bebé Sacudido/diagnóstico , Índices de Gravedad del Trauma , Heridas no Penetrantes/diagnóstico , Síndrome del Niño Maltratado/mortalidad , Daño Encefálico Crónico/mortalidad , Lesiones Encefálicas/mortalidad , Maltrato a los Niños/mortalidad , Femenino , Mortalidad Hospitalaria , Humanos , Lactante , Recién Nacido , Tiempo de Internación , Masculino , Riesgo , Síndrome del Bebé Sacudido/mortalidad , Tasa de Supervivencia , Tomografía Computarizada por Rayos X , Ultrasonografía Doppler Transcraneal , Heridas no Penetrantes/mortalidad
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