Obturator Hernia in a Patient Undergoing Hemodialysis.

Obturator hernia is a rare condition that commonly affects frail older women. A 54-year-old woman presented to our hospital with left hip joint pain. She had suffered a left pubic bone fracture and commenced maintenance hemodialysis. Pelvic computed tomography (CT) showed an incarcerated small intestine through the left obturator foramen, while abdominal CT showed marked intestinal dilatation. She underwent emergency laparotomy, and the incarcerated small intestine was found to be necrotic. Partial small intestinal resection and bilateral obturator hernioplasty were performed. Because obturator hernia is a potentially fatal condition, early detection and treatment are important.

10-GHz-clock time-multiplexed non-degenerate optical parametric oscillator network with a variable planar lightwave circuit interferometer.

A coherent XY machine (CXYM) is a physical spin simulator that can simulate the XY model by mapping XY spins onto the continuous phases of non-degenerate optical parametric oscillators (NOPOs). Here, we demonstrated a large-scale CXYM with >47,000 spins by generating 10-GHz-clock time-multiplexed NOPO pulses via four-wave mixing in a highly nonlinear fiber inside a fiber ring cavity. By implementing a unidirectional coupling from the ith pulse to the (i + 1)th pulse with a variable 1-pulse delay planar lightwave circuit interferometer, we successfully controlled the effective temperature of a one-dimensional XY spin network within two orders of magnitude.

Spectral-brightness optimization of an X-ray free-electron laser by machine-learning-based tuning.

A machine-learning-based beam optimizer has been implemented to maximize the spectral brightness of the X-ray free-electron laser (XFEL) pulses of SACLA. A new high-resolution single-shot inline spectrometer capable of resolving features of the order of a few electronvolts was employed to measure and evaluate XFEL pulse spectra. Compared with a simple pulse-energy-based optimization, the spectral width was narrowed by half and the spectral brightness was improved by a factor of 1.7. The optimizer significantly contributes to efficient machine tuning and improvement of XFEL performance at SACLA.

Minimal change nephrotic syndrome diagnosed with acute femoral thromboembolism and successfully salvaged limb: a case report.

A 64-year-old man visited the outpatient department of our hospital for the first time due to bilateral lower limb edema, which he noticed 1 week before the visit. Pain suddenly developed in the left lower limb while the patient was in the waiting room. Nephrotic syndrome was suspected based on blood and urine test results. Acute arterial thromboembolism in the left lower limb associated with hypercoagulation due to nephrotic syndrome was suspected, and a diagnosis was made using computed tomography angiography. Arterial thrombectomy was urgently performed, and the limb was salvaged without sequelae. Based on renal biopsy, minimal change nephrotic syndrome was diagnosed, and the patient underwent remission induction with steroid therapy. Heparin was drip infused and apixaban was orally administered to prevent recurrent thrombosis. Nephrotic syndrome in the acute phase is often complicated by thrombosis. Particularly, arterial thromboembolism requires prompt treatment, and prophylactic anticoagulation therapy needs to be considered.

100,000-spin coherent Ising machine.

Computers based on physical systems are increasingly anticipated to overcome the impending limitations on digital computer performance. One such computer is a coherent Ising machine (CIM) for solving combinatorial optimization problems. Here, we report a CIM with 100,512 degenerate optical parametric oscillator pulses working as the Ising spins. We show that the CIM delivers fine solutions to maximum cut problems of 100,000-node graphs drastically faster than standard simulated annealing. Moreover, the CIM, when operated near the phase transition point, provides some extremely good solutions and a very broad distribution. This characteristic will be useful for applications that require fast random sampling such as machine learning.

Collective and synchronous dynamics of photonic spiking neurons.

Nonlinear dynamics of spiking neural networks have recently attracted much interest as an approach to understand possible information processing in the brain and apply it to artificial intelligence. Since information can be processed by collective spiking dynamics of neurons, the fine control of spiking dynamics is desirable for neuromorphic devices. Here we show that photonic spiking neurons implemented with paired nonlinear optical oscillators can be controlled to generate two modes of bio-realistic spiking dynamics by changing optical-pump amplitude. When the photonic neurons are coupled in a network, the interaction between them induces an effective change in the pump amplitude depending on the order parameter that characterizes synchronization. The experimental results show that the effective change causes spontaneous modification of the spiking modes and firing rates of clustered neurons, and such collective dynamics can be utilized to realize efficient heuristics for solving NP-hard combinatorial optimization problems.

Continuous and long-term stabilization of degenerate optical parametric oscillators for large-scale optical hybrid computers.

The minimum requirements for an optical reservoir computer, a recent paradigm for computation using simple algorithms, are nonlinearity and internal interactions. A promising optical system satisfying these requirements is a platform based on coupled degenerate optical parametric oscillators (DOPOs) in a fiber ring cavity. We can expect advantages using DOPOs for reservoir computing with respect to scalability and reduction of excess noise; however, the continuous stabilization required for reservoir computing has not yet been demonstrated. Here, we report the continuous and long-term stabilization of an optical system by introducing periodical phase modulation patterns for DOPOs and a local oscillator. We observed that the Allan variance of the optical phase up to 100 ms was suppressed and that the homodyne measurement signal had a relative standard deviation of 1.4% over 62,500 round trips. The proposed methods represent important technical bases for realizing stable computation on large-scale optical hybrid computers.

Observation of binary phase states of time-multiplexed degenerate optical parametric oscillator pulses generated using a nonlinear fiber Sagnac loop.

We generated time-multiplexed degenerate optical parametric oscillator (DOPO) pulses using a nonlinear fiber Sagnac loop as a phase-sensitive amplifier (PSA), where the pump and amplified light in pump-signal-idler degenerate four-wave mixing can be spatially separated. By placing the PSA in a fiber cavity, we successfully generated more than 5000 time-multiplexed DOPO pulses. We confirmed the bifurcation of pulse phases to 0 or π relative to the pump phase, which makes them useful for representing Ising spins in an Ising model solver based on coherent optical oscillator networks. We also confirmed inherent randomness of the DOPO phases using the National Institute of Standards and Technology random number test.

Thermally modified C-band acceleration unit for a high-repetition normal-conducting linac for free-electron lasers.

A high-repetition linear accelerator with multibeamline operation for X-rays allows users to perform multiple simultaneous experiments with an X-ray free-electron laser (XFEL) at lower actual cost per user while maintaining the availability of the laser. As the first step toward a higher pulse repetition rate (PRR), we developed radio frequency (RF) components at 5712 MHz and tested them for their feasibility at an RF PRR of 120 pulses per second (pps). To increase the RF PRR from the present value of 60 pps-at the SPring-8 Angstrom compact free-electron laser-to 120 pps, we re-examined the thermal designs of the present RF components for the XFEL. With the proposed design, the newly developed RF components worked well at 120 pps. The insulation-oil temperature in the high-voltage tank of the klystron modulator was below 70 °C, which is less than the operational temperature limit. At 5712 MHz, this is now the highest RF pulse repetition frequency yet to be achieved and represents a major step toward higher PRRs.

Experimental investigation of performance differences between coherent Ising machines and a quantum annealer.

Physical annealing systems provide heuristic approaches to solving combinatorial optimization problems. Here, we benchmark two types of annealing machines-a quantum annealer built by D-Wave Systems and measurement-feedback coherent Ising machines (CIMs) based on optical parametric oscillators-on two problem classes, the Sherrington-Kirkpatrick (SK) model and MAX-CUT. The D-Wave quantum annealer outperforms the CIMs on MAX-CUT on cubic graphs. On denser problems, however, we observe an exponential penalty for the quantum annealer [exp(-αDW N 2)] relative to CIMs [exp(-αCIM N)] for fixed anneal times, both on the SK model and on 50% edge density MAX-CUT. This leads to a several orders of magnitude time-to-solution difference for instances with over 50 vertices. An optimal-annealing time analysis is also consistent with a substantial projected performance difference. The difference in performance between the sparsely connected D-Wave machine and the fully-connected CIMs provides strong experimental support for efforts to increase the connectivity of quantum annealers.

Understanding dynamics of coherent Ising machines through simulation of large-scale 2D Ising models.

Many problems in mathematics, statistical mechanics, and computer science are computationally hard but can often be mapped onto a ground-state-search problem of the Ising model and approximately solved by artificial spin-networks of coupled degenerate optical parametric oscillators (DOPOs) in coherent Ising machines. To better understand their working principle and optimize their performance, we analyze the dynamics during the ground state search of 2D Ising models with up to 1936 mutually coupled DOPOs. For regular as well as frustrated and disordered 2D lattices, the machine finds the correct solution within just a few milliseconds. We determine that calculation performance is limited by freeze-out effects and can be improved by controlling the DOPO dynamics, which allows to optimize performance of coherent Ising machines in various tasks. Comparisons with Monte Carlo simulations reveal that coherent Ising machines behave like low temperature spin systems, thus making them suitable for optimization tasks.

A stable pulsed power supply for multi-beamline XFEL operations.

Since an X-ray Free Electron Laser (XFEL) facility is a linac-based single-user machine, a multi-beamline mode of operation, which improves the efficiency of user experiments, is critical for accommodating users' rapidly increasing demand for beamtime. A key supporting technology is a highly stable pulsed power supply (PS), which enables stable XFEL operations by precisely switching the beam route. We developed a high-power pulsed PS to drive a kicker magnet installed in a SACLA's beam switching system. SiC MOSFETs were adapted as switching elements to reduce the required size and to increase the electric power efficiency. The PS we developed provides two key capabilities: (i) a high current stability of 20 ppm (peak-to-peak) at a peak power of 0.24 MW and (ii) generation of controllable, bipolar, and trapezoidal current waveforms at 60 Hz. This paper describes the overall concept, the detailed design, the performance achieved, and the initial beam test results.

A soft X-ray free-electron laser beamline at SACLA: the light source, photon beamline and experimental station.

The design and performance of a soft X-ray free-electron laser (FEL) beamline of the SPring-8 Compact free-electron LAser (SACLA) are described. The SPring-8 Compact SASE Source test accelerator, a prototype machine of SACLA, was relocated to the SACLA undulator hall for dedicated use for the soft X-ray FEL beamline. Since the accelerator is operated independently of the SACLA main linac that drives the two hard X-ray beamlines, it is possible to produce both soft and hard X-ray FEL simultaneously. The FEL pulse energy reached 110 µJ at a wavelength of 12.4 nm (i.e. photon energy of 100 eV) with an electron beam energy of 780 MeV.

A coherent Ising machine for 2000-node optimization problems.

The analysis and optimization of complex systems can be reduced to mathematical problems collectively known as combinatorial optimization. Many such problems can be mapped onto ground-state search problems of the Ising model, and various artificial spin systems are now emerging as promising approaches. However, physical Ising machines have suffered from limited numbers of spin-spin couplings because of implementations based on localized spins, resulting in severe scalability problems. We report a 2000-spin network with all-to-all spin-spin couplings. Using a measurement and feedback scheme, we coupled time-multiplexed degenerate optical parametric oscillators to implement maximum cut problems on arbitrary graph topologies with up to 2000 nodes. Our coherent Ising machine outperformed simulated annealing in terms of accuracy and computation time for a 2000-node complete graph.

A fully programmable 100-spin coherent Ising machine with all-to-all connections.

Unconventional, special-purpose machines may aid in accelerating the solution of some of the hardest problems in computing, such as large-scale combinatorial optimizations, by exploiting different operating mechanisms than those of standard digital computers. We present a scalable optical processor with electronic feedback that can be realized at large scale with room-temperature technology. Our prototype machine is able to find exact solutions of, or sample good approximate solutions to, a variety of hard instances of Ising problems with up to 100 spins and 10,000 spin-spin connections.

10 GHz clock time-multiplexed degenerate optical parametric oscillators for a photonic Ising spin network.

A coherent Ising machine based on degenerate optical parametric oscillators (DOPOs) is drawing attention as a way to find a solution to the ground-state search problem of the Ising model. Here we report the generation of time-multiplexed DOPOs at a 10 GHz clock frequency. We successfully generated >50,000 DOPOs using dual-pump four-wave mixing in a highly nonlinear fiber that formed a 1 km cavity, and observed phase bifurcation of the DOPOs, which suggests that the DOPOs can be used as stable artificial spins. In addition, we demonstrated the generation of more than 1 million DOPOs by extending the cavity length to 21 km. We also confirmed that the binary numbers obtained from the DOPO phase-difference measurement passed the NIST random number test, which suggests that we can obtain unbiased artificial spins.

Entanglement distribution over 300 km of fiber.

We report the distribution of time-bin entangled photon pairs over 300 km of optical fiber. We realized this by using a high-speed and high signal-to-noise ratio entanglement generation/evaluation setup that consists of periodically poled lithium niobate waveguides and superconducting single photon detectors. The observed two-photon interference fringes exhibited a visibility of 84%. We confirmed the violation of Bell's inequality by 2.9 standard deviations.

Polarization independent varifocal lens using KTN crystals.

We fabricated a polarization-independent varifocal lens using KTa(1-x)Nb(x)O3 (KTN) crystals. The polarization dependence of the KTN crystal is effectively compensated for by combining a pair of KTN lenses and a half-wave plate. This compensation is achieved by a total electro-optic effect, which consists of the Kerr effect and the elasto-optic effects via the electrostrictive and elastic strains in the KTN crystal.

Spin state tomography of optically injected electrons in a semiconductor.

Spin is a fundamental property of electrons, with an important role in information storage. For spin-based quantum information technology, preparation and read-out of the electron spin state are essential functions. Coherence of the spin state is a manifestation of its quantum nature, so both the preparation and read-out should be spin-coherent. However, the traditional spin measurement technique based on Kerr rotation, which measures spin population using the rotation of the reflected light polarization that is due to the magneto-optical Kerr effect, requires an extra step of spin manipulation or precession to infer the spin coherence. Here we describe a technique that generalizes the traditional Kerr rotation approach to enable us to measure the electron spin coherence directly without needing to manipulate the spin dynamics, which allows for a spin projection measurement on an arbitrary set of basis states. Because this technique enables spin state tomography, we call it tomographic Kerr rotation. We demonstrate that the polarization coherence of light is transferred to the spin coherence of electrons, and confirm this by applying the tomographic Kerr rotation method to semiconductor quantum wells with precessing and non-precessing electrons. Spin state transfer and tomography offers a tool for performing basis-independent preparation and read-out of a spin quantum state in a solid.

Pharmacokinetic interactions between Japanese traditional Kampo medicine and modern medicine (IV). Effect of Kamisyoyosan and Tokisyakuyakusan on the pharmacokinetics of etizolam in rats.

Kamisyoyosan (KSS) and Tokisyakuyakusan (TSS) are widely used herbal formulas in Japanese traditional kampo medicine to relieve the symptoms occurred in climacteric disturbance. Since Japanese physicians frequently prescribe these formulas combined with etizolam, one of benzodiazepine anxiolytics, we evaluated the pharmacokinetic interaction between KSS or TSS and etizolam, and in vitro inhibitory effect of KSS and TSS on rat cytochrome P450 (CYP) 3A activity in rat microsomes, to obtain drug information to prevent from disadvantage or adverse effects by their combined therapy. In in vitro experiment, KSS and TSS inhibited CYP3A activity comparable to grapefruit juice. However in in vivo experiments, oral administration of KSS did not influence the plasma concentration profile of etizolam. The maximum concentration (Cmax) of etizolam was significantly reduced when TSS was co-administered at 20 times amount of human daily dosage. Since the double of human daily dose of TSS did not suppress the absorption of etizolam, TSS would not influence the pharmacokinetics of etizolam at the usual clinical dosage. Since both KSS and TSS did not influence the metabolism of etizolam, the result of in vitro experiment would not reflect to that of in vivo experiment or in clinic. The combination of etizolam with KSS or TSS at usual dosage would not cause drug interaction.