1.
Chemistry
; 20(37): 11695-8, 2014 Sep 08.
Artículo
en Inglés
| MEDLINE
| ID: mdl-25065781
RESUMEN
Monocarbonyl activation of 2,2-disubstituted malonic acids with benzotriazole leads to decarboxylation of one of the carboxy groups and formation of a CH bond. Intermediate carbonyl benzotriazoles then readily acylate nucleophilic reagents and peptides resulting in libraries of conjugates and peptidomimetics.