RESUMEN
Street samples (n = 31) of heroin were analysed by gas chromatography with flame ionisation detection to determine opiate, noscapine and papaverine content. Using this data, the chromatograms obtained could be resolved into eight groups by visual examination of the data. The concentrations of opiates were significantly correlated (P < 0.05) with the exception of the pairs 6-O-monoacetylmorphine/noscapine and morphine/6-O-monoacetylmorphine. This precludes the use of simple cluster analysis for determining and predicting the relationship of different street samples. Application of Fisher's linear discriminant analysis to the data set indicated that 91.9% of the samples could be discriminated including pairs which could not be discriminated by eye. A blind trial (n = 2) resulted in the correct assignment to street sample. Application of such methods may provide, in the future, a powerful tool for the prediction of batch membership of drugs at the street level.
Asunto(s)
Heroína/química , Narcóticos/química , Cromatografía de Gases , Análisis Discriminante , Heroína/clasificación , Narcóticos/análisis , Narcóticos/clasificación , Noscapina/análisis , Papaverina/análisis , Valor Predictivo de las PruebasRESUMEN
The application of supercritical fluid chromatography (SFC) in forensic science is reviewed. The applications centre on the analysis of explosives and of drugs of abuse. The systems employed are discussed in the context of comparison with gas chromatography and high-performance liquid chromatography methods which are traditionally used for such analyses. The advantages and disadvantages of SFC over these methods are discussed. Recommendations are made for the developments which are required in SFC technology if it is to find greater application in forensic science.
