Clinical value of immunoscintigraphy in the rectal carcinomas: immunoscintigraphy of rectal carcinomas.

BACKGROUND/AIM: The aim of this study was to evaluate the clinical reliability of the immunoscintigraphy with radiolabeled monoclonal antibodies for the detection of metastases and recurrences of rectal carcinomas. METHODOLOGY: A total of 65 patients underwent immunoscintigraphy with radiolabeled monoclonal antibodies. Indication for that examination was suspicious rectal cancer or suspicious rectal cancer recurrence and/or metastases. RESULTS: The method proved to have 92.7% sensitivity, specificity 83.3%, positive predictive value 90.5%, negative predictive value 87.0% and accuracy 89.2%. There was a statistically significant relationship between immunoscintigraphy findings and rectoscopy findings (rs=0.415, p=0.013), as well as significant relationship between immunoscintigraphy findings and US findings (rs=0.332, p=0.001). Tumor marker levels were in positive correlation with findings of immunoscintigraphy (rs=0.845, p=0.001), especially raised CEA level (rs=0.816, p=0.004). Patients with higher CA19-9 level had higher Duke's stage (p=0.025). CONCLUSIONS: We can conclude that immunoscintigraphy can be helpful in the detection of metastases and recurrences of colon carcinomas.

Scintigraphic detection of colon carcinomas with iodinated monoclonal antibodies.

PURPOSE: The aim of this study was to evaluate the clinical reliability of the immunoscintigraphy with iodinated monoclonal antibodies for the detection of metastases and recurrences of colon carcinomas. METHODS: A total of 45 patients with colon carcinoma was investigated with gamma camera, after intravenous application of iodinated monoclonal antibodies. RESULTS: The sensitivity of the method was 90%, specificity 86%, positive predictive value 93%, negative predictive value 80% and accuracy 87%. There was statistically significant relationship between immunoscintigraphic and ultrasonographic (US) findings (p=0.005). Also, there was significant relationship between immunoscintigraphy and Dukes stage (p=0.019). Tumor marker levels were not significantly correlated with immunoscintigraphic findings (p<0.05). Significant difference was noted in patients with positive findings for malignancy on US and immunoscintigraphic findings (p=0.006), i.e. patients with positive findings for malignancy had more frequently immunoscintigraphic findings of malignancy. Correlation with other diagnostic procedures (rectoscopy, colonoscopy, CT) did not show significant correlations. CONCLUSION: We conclude that immunoscintigraphy can be helpful in the detection of metastases and recurrences of colon carcinomas.

[Evaluation of perfusion of transplanted microvascular flaps using radionuclide arteriography]. / Procena prokriljenosti transplantiranih mikrovaskularnih reznjeva primenom radionukleidne arteriografije.

Microvascular flap by its autonomous circulation, following the transplantation in recipient region, provides the quantity of blood sufficient for nutritive needs of flap, but it also provides additional blood supply in the surrounding of recipient region. The evaluation of the relation of the tissues perfusion of transferred microvascular flaps and the tissues of surrounding recipient region was done in 33 patients, 15.24 months after the transplantation of microvascular flaps, by radionuclide angiography using Tc-99m in the form of MAA HAS or pertechnetate at the Clinic for Plastic Surgery and Burns of Military Medical Academy (MMA) and at the Institute for Nuclear Medicine of MMA. Cutaneous, myocutaneous and osteocutaneous microvascular flaps were transferred to the foot, lower leg and in the head region. The obtained results revealed that the perfusion of the tissue of transferred flaps was better than the perfusion of the recipient region surrounding (232%). Perfusion of myocutaneous flaps related to the type of microvascular flap was the highest and came to 244% of the perfusion of the recipient region surrounding. Accumulation of radiopharmaceuticals in the tissue of the flap was homogenous in 19 (57.57%) flaps.