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Synthesis and Structural Characterization of Macrocyclic α-ABpeptoids and Their DNA-Encoded Library.
Org Lett
; 26(5): 1100-1104, 2024 02 09.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38295374
RESUMEN
The first synthesis of macrocyclic α-ABpeptoids with varying lengths is described. X-ray crystal structures reveal that cyclic trimer displays a chair-like conformation with a cct amide sequence and cyclic tetramer has a saddle-like structure with an uncommon cccc amide arrangement. The creation of a DNA-encoded combinatorial library of macrocyclic α-ABpeptoids is described.