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Pathol Res Pract ; 213(9): 1200-1206, 2017 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-28736088

RESUMEN

BACKGROUND: For Down syndrome (DS), traditional epidemiological studies to determine the prevalence, cause, and clinical significance of the syndrome have been conducted over the last 100 years. In Tunisia, the current work is the first in-depth study in epidemiology of DS from fetopathological data. AIM OF THE STUDY: The aim of this epidemiological study was to determine the impact of some feto-maternal characteristics in occurrence of DS and to search the frequency of associated congenital malformations with this syndrome. METHODS: Our retrospective study was realized for 144 fetuses with DS among 9321 autopsied fetuses in embryo-fetopathological service between 1994 and 2011. RESULTS: In our study, the majority of mothers (72.91%) were 35 years and older, with a statistically significant difference (p<10-6, OR=16.7, CI=8.7-32.4). The abnormalities of extremities (31%) were the most common fetal abnormalities followed by facial (23.51%) and digestive abnormalities (19.63%). CONCLUSION: One of the main conclusions of this research is that the most common risk factor for DS is maternal age. On the other hand, the type and the frequency of associated congenital anomalies with DS are still controversial.


Asunto(s)
Anomalías Múltiples/epidemiología , Anomalías Múltiples/etiología , Anomalías Múltiples/patología , Síndrome de Down/patología , Adulto , Síndrome de Down/epidemiología , Femenino , Feto , Humanos , Masculino , Edad Materna , Embarazo , Estudios Retrospectivos , Túnez/epidemiología
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