Exploring sleep characteristics in Chinese patients with narcolepsy: insights from the nocturnal sleep onset rapid eye movement period (nSOREMP).

STUDY OBJECTIVES: This study aims to investigate the unique characteristics and clinical significance of the nocturnal sleep onset rapid eye movement period (nSOREMP) in the Chinese population with narcolepsy, enhancing our understanding and management of the disorder globally. METHODS: This retrospective analysis investigated narcolepsy in Chinese patients from six hospitals, using International Classification of Sleep Disorders. A parallel retrospective analysis of the Chinese Clinical Sleep Database (CCSD) focused on polysomnography (PSG) records was conducted to evaluate nSOREMP prevalence in other sleep disorders. RESULTS: The study found a 2.51% nSOREMP prevalence in other sleep disorders of CCSD. Significant differences in age, N2 and rapid eye movement (REM) percentages, REM latency, and various indexes were noted among narcolepsy with/without nSOREMP, and other sleep disorders with nSOREMP of CCSD. nSOREMP prevalence in NT1 was 33.33% and in NT2, 28.30%. Noteworthy disparities in NT1 included N2 percentages, REM latency, and SOREMPs in Multiple Sleep Latency Test (MSLT). In NT2, differences were significant in age, sleep latency, N2 and REM latencies, arousal index, mean sleep latency in MSLT, and MSLT SOREMPs. CONCLUSIONS: This study highlights the distinct characteristics of nSOREMP in the Chinese population. Patients exhibiting symptoms suggestive of the onset of narcolepsy are advised to undergo an MSLT, irrespective of the occurrence of SOREMP during nocturnal PSG.

Significant underestimation of radiative forcing by aerosol-cloud interactions derived from satellite-based methods.

Satellite-based estimates of radiative forcing by aerosol-cloud interactions (RFaci) are consistently smaller than those from global models, hampering accurate projections of future climate change. Here we show that the discrepancy can be substantially reduced by correcting sampling biases induced by inherent limitations of satellite measurements, which tend to artificially discard the clouds with high cloud fraction. Those missed clouds exert a stronger cooling effect, and are more sensitive to aerosol perturbations. By accounting for the sampling biases, the magnitude of RFaci (from -0.38 to -0.59 W m-2) increases by 55 % globally (133 % over land and 33 % over ocean). Notably, the RFaci further increases to -1.09 W m-2 when switching total aerosol optical depth (AOD) to fine-mode AOD that is a better proxy for CCN than AOD. In contrast to previous weak satellite-based RFaci, the improved one substantially increases (especially over land), resolving a major difference with models.

Spatial and seasonal characteristics of particulate matter and gaseous pollution in China: Implications for control policy.

By employing the air pollution data including particular matter (PM) and gaseous pollutants (SO2, NO2, CO, and O3) measured over 130 cities in China from April 2014 to March 2015, the spatial and seasonal variations of air pollution are analyzed. The 9 representative regions including Beijing, Tianjin, and Hebei (BTH), Yangze River Delta (YRD), central China (CC), Sichuan Basin (SB), northeast China (NEC), northwest China (NWC), Pearl River Delta (PRD), Yungui Plateau (YP), and Tibet, are chose to quantify the conditions of PM and gaseous pollution. According to the magnitudes of PM2.5 from high to low, the regions are listed in sequence as BTH, CC, SB, YRD, NEC, NWC, PRD, YP, and Tibet. The spatial patters of gaseous pollutants except O3 are generally consistent with PM's. The CO maximum is found in BTH and NWC while the O3 maximum in YRD, PRD, and Tibet. The seasonal cycles of SO2 and NO2 are quite similar to that of PM, but the SO2 is overall higher than NO2 in winter over the northern China while the opposite is true over the southern China. The O3 concentrations are generally low in winter, but high in spring and summer due to active photochemical reaction when temperature is high. The percentage of haze days (daily PM2.5 exceeds NAAQS Grade II, i.e. 75  µg m-3) to the entire year is 45, 32 and 29%, respectively over BTH, CC, and SB, three most PM pollution regions during the study period. Although the most severe haze region occurs in BTH (139 days) from annual mean, the most severe winter in SB (54 days) owing to its basin landform and high air pollutant emissions. In contrary to PM pollution, gaseous pollution in China are overall quite trivial.

Aerosol optical properties and direct radiative forcing at Taihu.

Ground-based characteristics (optical, type, size, and radiative properties) of aerosols measured between 2005 and 2012 were investigated over the Taihu rim region, which encompasses the cities of Shanghai, Suzhou, Wuxi, and Changzhou. The aerosol optical depth (AOD) showed a distinct seasonal variation with the highest value in summer and the lowest AOD in winter. There was broadest frequency distribution with a multimodal structure in summer. The Ångström exponent (AE) showed high values during spring; the relative frequency of AE in the range of 0-0.8 was 5-10 times greater than that of other seasons. The samples with high AOD440 and low AE440-870 were mainly observed in spring, which is attributed to the relative abundance of coarse particles. The monthly aerosol volume size distributions presented a bimodal structure (fine and coarse modes). The coarse mode was dominant during spring, while the fine mode was predominant in other seasons. The main aerosol type over Taihu during all the seasons was the mixed small-particle category, followed by the urban/industrial category. The minimum single scattering albedo (SSA) occurred in winter, suggesting that atmosphere aerosol had a higher absorption. All monthly averaged asymmetry factors (ASY) had positive values and no distinct seasonal variation. Both high real (Re) and imaginary (Im) parts of the refractive index occurred in winter. The atmospheric warming effect of aerosol was more significant in winter compared with other seasons, with the averaged atmosphere aerosol radiative forcing (ARF) and the corresponding atmospheric heating rate up to +69.46 W·m-2 and 1.95 K·day-1, respectively. There existed a significant positive correlation between AOD and ARF (absolute value), and the correlation coefficients (r) exceeded 0.86 in each season with maximum r in summer. Along with the increasing of the SSA, the aerosol radiative forcing efficiency (absolute value) showed a decreasing trend at the bottom of the atmosphere and an increasing trend at the top of the atmosphere.