Effects of Modified Sang ju-Yin Decoction Combined with IFNαlb Nebulization on IL-1ß and HBD2 in Children with Asthmatic Bronchitis.

Background: Breathing disease swelling of the lung tubes caused by viral infection is more and more likely to develop into related to the lung tubes breathing disease, especially repeating breathing loudly. Objective: To investigate the effect of modified Sang ju-Yin Decoction combined with Interferon (IFN)αlb nebulization on children with asthmatic bronchitis and the effects of IL-1ß and ß-defensin 2 (HBD2). Materials and Methods: The clinical data of 80 children with asthmatic bronchitis who were diagnosed and treated in our hospital from May 2019 to May 2021 were selected as the research objects and divided into the control group and the observation group with 40 cases in each group according to different treatment methods. Among them, the control group was nebulized with IFNαlb, and the observation group was given addition and subtraction of Sang ju-Yin Decoction based on the control group. The clinical symptoms, pulmonary function indexes, adverse reactions, and effects on serum inflammatory indexes were observed and compared between the two groups. Results: There was no significant difference in the scores of symptoms and signs between the two groups before treatment (P > 0.05), while the scores of shortness of breath, cough, stridor, lung rales, and signs after treatment of observation group were better than those of the control group (P < 0.05). There was no significant difference in serum inflammatory indexes and pulmonary function indexes between the two groups before treatment (P > 0.05), while the differences in IL-6, IL-10, TNF-α, IL-1ß, and HBD2 after treatment were significant between the two groups (P < 0.05). After treatment, the RR, TV, and PEF indexes of the two groups of children were significantly improved (P < 0.05). After treatment, the adverse reaction rate of liver function damage, dry throat discomfort, rash, nausea, and vomiting in the observation group was 7.5%, which was significantly lower than 27.5% in the control group (P < 0.05). Conclusion: Modified Sang ju-Yin Decoction combined with IFNαlb nebulization can improve symptoms and promote the recovery of patients in the treatment of acute bronchitis.

Effect of two administration routes of Shenmai Injection () on pulmonary gas exchange function after tourniquet-induced ischemia-reperfusion.

OBJECTIVE: To compare the effect between nebulized and intravenous administration of Shenmai Injection () on pulmonary gas exchange function of patients following tourniquet-induced lower limb ischemia-reperfusion. METHODS: Thirty-eight patients scheduled for lower extremity surgery were randomized into three groups using the closed envelop method: Shenmai Injection was administered 30 min before tourniquet inflflation by nebulization [0.6 mL/kg in 10 mL normal saline (NS)] in the nebulization group or by intravenous drip (0.6 mL/kg dissolved in 250 mL of 10% glucose) in the intravenous drip group, and equal volume of NS was given intravenously in the NS group; 15 in each group. Arterial blood gases were analyzed, serum levels of malonaldehyde (MDA) and interleukine-6 (IL-6) and interleukine-8 (IL-8) were determined using the method of thiobarbituric acid reaction and enzyme-linked immuno sorbent assay respectively just before tourniquet inflflation (T0), and at 0.5 h (T1), 2 h (T2), 6 h (T3) after tourniquet deflflation. RESULTS: Compared with baselines at T0, MDA levels signifificantly increased at T2, T3 in the NS group and at T3 in the nebulization group, and IL-6 and IL-8 levels were signifificantly increased at T2, T3 in NS, the intravenous drip and the nebulization groups (P <0.05). Arterial pressure of oxygen (PaO2) at T3 was decreased, while alveolararterial oxygen tension showed difference (PA-aDO2) at T3 in the NS group; RI at T3 in both intravenous drip and the nebulization groups were enhanced (P <0.05). Compared with the NS group, MDA and IL-8 levels at T2, T3, IL-6 at T3 in the intravenous drip group, and IL-8 at T3 in the nebulization group were all remarkably increased (P <0.05). Additionally, MDA level at T3 in the nebulization group was higher than that in the intravenous drip group (P <0.05). CONCLUSIONS: Intravenous administration of Shenmai Injection provided a better protective effect than nebulization in mitigating pulmonary gas exchange dysfunction in patients following tourniquet-induced limb ischemia-reperfusion.

[Feasibility study of controlled hypotension induced with combination of propofol and desflurane in craniotomy].

OBJECTIVE: To evaluate the feasibility of controlled hypotension induced with combination of propofol and desflurane in craniotomy. METHODS: Thirty-five ASA I approximately II patients undergoing elective craniotomy were randomly selected. Anesthetic induction was achieved with midazolam, thiopental, fentanyl, and vecuronium. Anesthesia was maintained with infusion of propofol and inhalation of desflurane. The propofol infusion rate and desflurane inhalation concentration were raised during isolation and resection of the tumors so that the mean arterial pressure (MAP) was reduced by 30% - 40% and > 50 mm Hg and maintained at this level for 30 - 45 min. After the resection of tumor, the propofol infusion rate and desflurane inhalation concentration were reduced so as to let the MAP increase to normal level. MAP, heart rate (HR), cerebrospinal fluid pressure (CSFP), propofol infusion rate, and inhalation concentration of desflurane were recorded before controlled hypotension, at the 1st, 3rd, 5th, 10th, 20th and 30th minute of the procedure of controlled hypotension, and just before the increase of blood pressure and 1, 3, 5, 10, 20, 30, 40 and 50 minutes after controlled hypotension. The awakening status was observed. Arterial and jugular bulb venous blood samples were taken before, during and after hypotension and the arterial to jugular bulb venous oxygen content difference [D(a-jv)O(2)] and cerebral oxygen extraction rate (ERO(2)) were measured. RESULTS: The time needed to reach controlled hypotension was 6 - 35 minutes and that needed to reach the normal blood pressure was 12 - 41 minutes. The propofol infusion rate and inhalation concentration of desflurane needed to maintain controlled hypotension were 51 micro g x kg(-1) x min(-1) +/- 27 micro g x kg(-1) x min(-1) and 6.4% +/- 4.1% respectively. HR increased significantly in the initial stage and returned to baseline value after 3 - 14 min during the controlled hypotension. CSFP decreased significantly after incision of dura mater of brain and during controlled hypotension (P < 0.05). The recovery time after weaning from propofol infusion and desflurane inhalation until eye opening in response to order and autonomous breathing was 25 min +/- 19 minutes. The time needed to regain autonomous breathing with the tidal volume > 300 ml/time was 17 min +/- 10 minutes. Compared with those before hypotension, the SjvO(2) was increased significantly, and D(a-jv)O(2) and ERO(2) were decreased significantly during hypotension (P < 0.05). CaO(2) and CjvO(2) remained unchanged throughout the process of hypotension (P > 0.05). CONCLUSION: With low propofol infusion rate and low desflurane inhalation concentration, rapid hypotension, rapid recovery of breathing after operation, a short recovery time from anesthesia, and decreased CSFP and brain oxygen metabolism, controlled hypotension with propofol infusion and desflurane inhalation is suitable to intracranial surgery.