Upper and lower blepharoplasty technique associated with canthopexy with double pre septal orbicularis muscle elevation with a single suture / Blefaroplastia superior e inferior associada à cantopexia com elevação dupla de músculo orbicular pré-septal em sutura única

ABSTRACT Objective: To describe the upper and lower blepharoplasty technique associated with canthopexy with double pre septal orbicularis muscle elevation with a single suture in order to evaluate the efficacy of the technique. Methods: This is a retrospective study in which the medical records of 5,882 patients who underwent this technique between January 1999 and July 2015 were evaluated. The frequency and main causes of clinical complications and surgical reoperation were analyzed. Results: The incidence of complications found was 12.7% (n=750), being 0.8% (n=47) due to persistent chemosis, 3% (n=176) due to poor lower eyelid positioning, 4.17% (n=245) due to mild eyelid retraction and 4.8% (n=282) because of mild to moderate chemosis. Conclusion: The technique appears to be effective as it is simple and practical, and capable of resulting in positive functional and aesthetic outcomes with low rates of complications.

RESUMO Objetivo: Descrever a técnica de blefaroplastia superior e inferior associada à cantopexia associada à dupla elevação do músculo orbicular pré-septal em uma única sutura e avaliar sua eficácia. Métodos: Trata-se de estudo retrospectivo, no qual foram avaliados 5.882 prontuários de pacientes submetidos à blefaroplastia superior e inferior com a utilização da cantopexia, entre janeiro de 1999 e julho de 2015. Taxas e principais causas de complicações clínicas e reintervenção cirúrgica foram analisadas. Resultados: A incidência de complicações encontradas foi de 12,7% (n=750), sendo 0,8% (n=47) de caso de quemose persistente, 3% (n=176) de mau posicionamento palpebral inferior (ectrópio), 4,17% (n=245) de leve retração pálpebra e 4,8% (n=282) de quemose leve a moderada. Conclusão: A técnica mostra-se eficaz por ser simples e prática, podendo ter resultados funcionais e estéticos positivos e com baixo índice de complicações.

Pathways Related to the Anti-Cancer Effects of Metabolites Derived from Cerrado Biome Native Plants: An Update and Bioinformatics Analysis on Oral Squamous Cell Carcinoma.

BACKGROUND: Oral cancer is a significant health problem worldwide. Oral squamous cell carcinoma (OSCC) is a malignant neoplasm of epithelial cells that mostly affects different anatomical sites in the head and neck and derives from the squamous epithelium or displays similar morphological characteristics. Generally, OSCC is often the end stage of several changes in the stratified squamous epithelium, which begin as epithelial dysplasia and progress by breaking the basement membrane and invading adjacent tissues. Several plant-based drugs with potent anti-cancer effects are considered inexpensive treatments with limited side effects for cancer and other diseases. OBJECTIVE: The aim of this review is to explore whether some Brazilian plant extracts or constituents exhibit anti-tumorigenic activity or have a cytotoxic effect on human oral carcinoma cells. METHODS: Briefly, OSCC and several metabolites derived from Brazilian plants (i.e., flavonoids, vinblastine, irinotecan, etoposide and paclitaxel) were used as keywords to search the literature on PubMed, GenBank and GeneCards. RESULTS: The results showed that these five chemical compounds found in Cerrado Biome plants exhibit anti-neoplastic effects. Evaluating the compounds revealed that they play a main role in the regulation of cell proliferation. CONCLUSION: Preserving and utilising the biodiversity of our planet, especially in unique ecosystems, such as the Cerrado Biome, may prove essential to preserving and promoting human health in modern contexts.

A utilização do álcool como mediador social entre universitários / The use of alcohol as a social mediator among university students / El uso de alcohol como mediador social entre universitarios

INTRODUÇÃO: o consumo de álcool entre adolescentes é maior entre os universitários e gera consequências acadêmicas negativas. Os hábitos de consumo adotados nesse período da vida são decisivos, já que, em sua maioria, são mantidos na vida adulta. OBJETIVO: avaliar a produção científica acerca da utilização do álcool como mediador social entre universitários. MÉTODO: revisão integrativa realizada nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), PUBMED e Scientific Eletronic Library Online (SciELO), com duas combinações dos cinco descritores: Consumo de bebidas alcoólicas; AND Estudantes; AND Educação Superior; AND Socialização; AND Álcool. RESULTADOS: na busca inicial, encontraram-se 665 artigos; após análise criteriosa e aplicação dos critérios de seleção, 21 foram utilizados. Como delineamento, prevaleceram 14 estudos qualitativos, 5 ensaios controlados randomizados, 1 não randomizado e 1 coorte. CONCLUSÃO: o alcoolismo entre universitários constitui um problema no âmbito da educação e saúde e que precisa de ações efetivas a fim de controlar suas consequências em curto e longo prazo.

INTRODUCTION: alcohol consumption is higher among college students and generates negative consequences. The habits adopted during this period of life are decisive because, for the most part, they will be maintained throughout life. OBJECTIVE: to evaluate the scientific production about the use of alcohol as social mediator among college students. METHOD: integrative review made in the Latin American and Caribbean Health Sciences Literature (LILACS), PUBMED and Scientific Eletronic Library Online (SciELO). Two combinations of the five descriptors were used, namely: Alcohol consumption; AND Students; AND Higher Education; AND Socialization; AND Alcohol. RESULTS: a total of 665 articles were found in the initial search; after careful analysis and application of the selection criteria, 21 articles were used. As for the design, there were 14 qualitative studies, 5 randomized controlled trials, 1 non-randomized trial and 1 cohort study, prevailed. CONCLUSION: alcoholism among college students is a problem in education and health and requires effective action to control its short- and long-term consequences.

INTRODUCCIÓN: el consumo de alcohol entre adolescentes es mayor entre los universitarios y genera consecuencias académicas negativas. Los hábitos de consumo adoptados en ese período de la vida son decisivos, ya que, en su mayoría, se mantienen en la vida adulta. OBJETIVO: evaluar la producción científica sobre el uso del alcohol como mediador social entre universitarios. MÉTODO: revisión integrativa realizada en las bases de datos Literatura Latino-Americana y de Caribe en Ciencias de la Salud (LILACS), PUBMED y Scientific Eletronic Library Online (SciELO). Con dos combinaciones de los cinco descriptores Consumo de bebidas alcohólicas; AND Estudiantes; AND Educación Superior; AND Socialización; AND Alcohol. RESULTADOS: en la búsqueda inicial se encontraron 665 artículos; después de un análisis riguroso y de la aplicación de los criterios de selección, 21 se utilizaron. Como delineamiento, prevalecieron 14 estudios cualitativos, 5 ensayos controlados aleatorizados, 1 no randomizado y 1 cohorte. CONCLUSIÓN: El alcoholismo entre universitarios constituye un problema en el ámbito de la educación y la salud y que necesita acciones efectivas para controlar sus consecuencias a corto y largo plazo.

Socioeconomic inequalities in the use of dental care services during early childhood: an epidemiological survey.

BACKGROUND: The use of dental care services contributes to the improvement of children's healthy behaviors, reducing the prevalence of future dental problems. In this way, the purpose of this study was to describe the use of dental care service during early childhood and the possible socioeconomic inequalities in this use. DESIGN: Data from the Brazilian Oral Health Survey (SB Brasil, 2010) were used. Interviews with the children's parents and clinical examinations with the children were conducted in a 5-year-old representative sample. Descriptive, bivariate and multiple hierarchical statistical analyses were applied. RESULTS: Of the 7241 children included, 3812 (53.2%) had used dental care services at least once in their lifetimes, and 1872 (48.8%) had used services for check-up/prevention. The use of dental services was greater among children with a higher family income (P < 0.05). The use of check-ups was lower among children with non-White skin color (Black and Browns) and among those who did not live in state capitals (P < 0.05). Clinical conditions and self-perception were also associated with the use (P < 0.05). CONCLUSION: Socioeconomic differences in the general use of dental care and in its use for check-ups were identified during early childhood, indicating the presence of inequalities.

Angiotensin-Converting Enzymes (ACE and ACE2) as Potential Targets for Malignant Epithelial Neoplasia: Review and Bioinformatics Analyses Focused in Oral Squamous Cell Carcinoma.

INTRODUCTION: The Renin-Angiotensin System (RAS) has emerged as being related to vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer. OBJECTIVE: This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting enzymes (ACE and ACE2) as therapeutical targets for Malignant Epithelial Neoplasia, specifically for Oral Squamous Cell Carcinoma (OSCC). CONCLUSION: The literature review and Bioinformatics analyses showed that ACE and ACE2 are interesting targets for OSCC treatment. Studies involving RAS and OSCC should be encouraged for experimental validation.

Hypoxia reduces the E-cadherin expression and increases OSCC cell migration regardless of the E-cadherin methylation profile.

OBJECTIVE: The purpose of the current study is to investigate the association between E-cadherin methylation status, hypoxia and OSCC. METHODS: HaCat and SCC9 cell lines were submitted to hypoxic treatment, followed by methylation profile analysis (MS-PCR) and analysis of the expression of mRNA gene E-cadherin (RT-PCR). Study group samples comprise individuals affected by potentially malignant lesions Potential Malignant Oral Lesion (PMOL, n=18) and oral squamous cell carcinoma (OSCC, n=28). The control group oral mucosa (OM, n=15) of patients with an oral mucocele. Cell migration ability was evaluated a scratch wound assay in SCC9 and HaCat cell lines RESULTS: E-cadherin mRNA expression in the cell lines SCC9 and HaCat was significantly reduced under hypoxia, regardless of the methylation profile, when compared to the control group. No differences in methylation profile of the E-cadherin were observed among the groups OM, PMOL and OSCC. HaCat and SCC9 presented increases in cell migration rates under hypoxia. CONCLUSION: The current study demonstrates that hypoxia reduces E-cadherin expression and increase cell migration, regardless of the methylation profile. Additionally, no differences in E-cadherin methylation patterns were observed among OM, PMOL and OSCC.

Impact of oral clinical problems on oral health-related quality of life in brazilian children: a hierarchical approach.

BACKGROUND: Oral health-related quality of life may be influenced by a series of characteristics. Considering the multidimensional character of quality of life, these impacts should be evaluated in the context of the physical, psychological, and social domains. AIM: To evaluate the impact of clinical and perceived oral health problems on oral health-related quality of life in its different domains. DESIGN: Clinical exams were conducted on a representative cross-sectional sample of 12-year-old children in Brazil. The instrument Oral Impacts on Daily Performance (OIDP) was used to evaluate the quality of life in relation to oral health. Descriptive, bivariate, and multiple hierarchical analyses were conducted. RESULTS: Of the 7328 children studied, 2577 (33.5%) presented oral health-related impacts on quality of life. Clinical and perceived conditions of oral health were associated with the presence of overall impacts in the physical, psychological, and social dimensions of oral health-related quality of life. Furthermore, Family income was associated with overall impacts and the level of motivation to use dental health services was associated with the physical dimension. CONCLUSIONS: The clinical and perceived conditions of oral health in Brazilian 12-year-olds were associated with a negative impact on oral health-related quality of life.

Perfil nutricional de pacientes adultos e idosos hospitalizados / Nutritional profile of hospitalized adults and elderly people

O objetivo do estudo foi avaliar os hábitos alimentares em adultos e idosos hospitalizados em um hospital público de Montes Claros (MG). Trata-se de uma pesquisa descritiva, quantitativa e transversal. Foram utilizados, para avaliação nutricional, o Índice de Massa Corporal (IMC) e a Avaliação Subjetiva Global (ASG). A amostra foi composta por 39 pacientes, de ambos os sexos, maiores de 18 anos, selecionados aleatoriamente, internados em um hospital público da cidade de Montes Claros (MG). Verificou-se que 32,35% dos pacientes eram eutróficos, com IMC > 20,5 kg/m², e 61,76% dos pacientes adultos eram obesos, com IMC > 25 kg/m². A desnutrição esteve presente em 5,88% dos pacientes adultos, com IMC < 20,5 kg/m². Com relação aos idosos, foram diagnosticados que 40% destes eram obesos e 20%, desnutridos. Em relação à ASG, adultos e idosos foram classificados na categoria C, gravemente desnutridos. O estado nutricional dos pacientes foi evidenciado pela alta prevalência de risco nutricional e sobrepeso/obesidade. Os resultados presentes evidenciam a importância da utilização de mais de um método de triagem nutricional em pacientes hospitalizados, para obter-se maior precisão na avaliação.

The feeding habits of hospitalized adults and elderly people in a government-run hospital in Montes Claros MG Brazil are evaluated. Current descriptive, quantitative and transversal research comprised nutritional evaluation, Body Mass Index (BMI) and Total Subjective Evaluation (TSE) of 39 patients, males and females, over 18 years old, randomly selected and hospitalized in a government-run hospital in Montes Claros MG Brazil. Further, 32.35% of patients were eutrophic, with BMI > 20.5 kg/m²; 61.76% were obese, with BMI > 25 kg/m². Undernourishment occurred in 5.88% of adult patients, with BMI < 20.5 kg/m². In the case of the elderly, 40% were obese and 20% were undernourished. In the case of TSE, adults and elderly were classified under category C, seriously undernourished. The patients´ nutritional state was proved by high prevalence of nutritional risks and overweight/obesity. Results revealed the importance of the employment of more than one method for nutritional selection in hospitalized patients for better evaluation.

Consumption profile and factors associated with the ingestion of beer and distilled beverages among elderly Brazilians: Gender differences.

AIM: To estimate the prevalence of the consumption of beer and distilled beverages and associated factors among Brazilian older adults residing in a highly populated city in Brazil, highlighting the factors associated with frequent consumption and differences in consumption between men and women. METHODS: It was a cross-sectional, analytic study carried out by means of probability samples of conglomerates of older adults (aged 65-74 years). Descriptive analysis, univariate analysis and estimates of multivariate models through logistic regression (OR, 95% CI) were realized. RESULTS: 500 of the 736 evaluated seniors were included in the present analysis. 128 (27.3%), 103 (21.3%) and 167 (34.9%) of the seniors indicate past or current use of beer, distilled beverages and frequent use of alcohol, respectively. The consumption of beer was associated with use of tobacco between women; and with marital status and schooling between men. The consumption of distilled beverages was associated with schooling and use of tobacco between women; and age and use of tobacco in men. Daily or weekly use was associated with schooling and use of tobacco between women; age and the use of tobacco between men. CONCLUSION: In the elderly population studied, a noteworthy prevalence of the consumption of beer and distilled beverages was identified, and this use was associated with personal and behavioral determinants. Similar associations related to frequent (daily or weekly) consumption were also identified. Significant differences in the profile of consumption were identified between men and women, with more abusive use among men. Geriatr Gerontol Int 2016; 16: 810-820.

Associations between oral disorders and the quality of life of older adults in Brazil.

AIM: To evaluate the effect of oral disorders on the quality of life of older adults. METHODS: A cross-sectional study of older adults (aged ≥ 60 years) who reside in a small Brazilian city was carried out. Trained and calibrated academics and dentists collected the data. The analyses carried out were descriptive, univariate and multiple through logistic regression using pasw Statistics 18.0 software. RESULTS: A total of 351 older adults were included in the study. The majority of older adults did not express impacts as a result of oral disorders. The physical domain of quality of life was compromises more in older adults who had physical incapacities related to oral health (odds ratio 3.62, 95% confidence interval 1.34-9.73). CONCLUSION: In general, among the older adults evaluated, it was found that both the overall score and the individual scores for the four domains of quality of life were influenced by one of the seven domains of the impacts of oral disorders.

Fuzzy clustering demonstrates that codon 72 SNP rs1042522 of TP53 gene associated with HNSCC but not with prognoses.

It is estimated that 7.6 million people will die as a consequence of head and neck squamous cell carcinoma (HNSCC). Genetic predisposition has emerged as an important risk factor in the development and prognosis of HNSCC. Considering this, the aim of the current study is to assess whether codon 72 SNP of the TP53 gene (rs1042522) is associated with an increased odds ratio of developing HNSCC or with a worse prognosis in patients with HNSCC. Analysis of the rs1042522 in HNSCC patients and in control individuals. Differences between the case and control groups were determined using chi-squared tests. Multivariate analysis was performed to evaluate the odds ratio of HNSCC. Fussy C Means Clustering was to cluster HNSCC patients for survival analyses. Time of survival was calculated using the Kaplan-Meier estimator and comparing this to the log rank test. Statistical significance was set at p < 0.05. A total of 71.4 % of the Arg/Arg genotype were from HNSCC patients, while only 28.6 % of Arg/Arg genotype were found in the control group. Logistic regression demonstrated that the Arg/Arg genotype, smoking, and alcohol consumption increase the odds ratio of HNSCC. No association between TP53 codon 72 polymorphism and P53 expression. No association between rs1042522 and survival or prognoses was observed. This study identified that individuals carrying the arginine allele at rs1042522 have an increased odds ratio of HNSCC. However, no association between codon 72 SNP of the TP53 gene and HNSCC prognosis or P53 expression was observed.

Need for orthodontic treatment among Brazilian adolescents: evaluation based on public health / Necessidade de tratamento ortodôntico em adolescentes brasileiros: avaliação com base na saúde pública

OBJECTIVE: To identify the prevalence and the severity of malocclusions and to analyze factors associated with the need for orthodontic treatment of Brazilian adolescents. METHODS: This exploratory, cross-sectional study was carried out based on secondary data from the national epidemiological survey on oral health in Brazil (2002-2003). Socio-demographic conditions, self-perception, and the existence and degree of malocclusion, using the Dental Aesthetic Index, were evaluated in 16,833 adolescent Brazilians selected by probabilistic sample by conglomerates. The dependent variable need orthodontic treatment was estimated from the severity of malocclusion. The magnitude and direction of the association in bivariate and multivariate analyzes from a Robust Poisson regression was estimated. RESULTS: The majority of the adolescents needed orthodontic treatment (53.2%). In the multivariate analysis, the prevalence of the need for orthodontic treatment was larger among females, non-whites, those that perceived a need for treatment, and those that perceived their appearance as normal, bad, or very bad. The need for orthodontic treatment was smaller among those that lived in the Northeast and Central West macro-regions compared to those living in Southeast Brazil and it was also smaller among those that perceived their chewing to be normal or their oral health to be bad or very bad. CONCLUSIONS: There was a high prevalence of orthodontic treatment need among adolescents in Brazil and this need was associated with demographic and subjective issues. The high prevalence of orthodontic needs in adolescents is a challenge to the goals of Brazil's universal public health system.

OBJETIVO: Identificar a prevalência e a gravidade das más oclusões e fatores associados com a necessidade de tratamento ortodôntico dos adolescentes brasileiros. MÉTODOS: Estudo transversal feito com base nos dados da pesquisa epidemiológica nacional em saúde bucal no Brasil (2002-2003). Condições sociodemográficas, autopercepção, existência e nível de gravidade da má oclusão, com o uso do Índice de Estética Dentária, foram avaliados em 16.833 adolescentes brasileiros selecionados por amostra probabilística por conglomerados. A variável dependente necessidade de tratamento ortodôntico foi estimada a partir da gravidade da má oclusão. A magnitude e a direção das associações nas análises bivariada e multivariada foram estimadas pela regressão de Poisson. RESULTADOS: A maioria dos adolescentes apresentou necessidade de tratamento ortodôntico (53,2%). Na análise multivariada, a prevalência da necessidade de tratamento ortodôntico foi maior entre as mulheres, os não brancos, aqueles que autopercebiam a necessidade de tratamento e aqueles que autopercebiam sua aparência como normal, ruim ou muito ruim. A necessidade de tratamento ortodôntico foi menor entre aqueles que viviam nas regiões Nordeste e Centro-Oeste em comparação com aqueles da Sudeste e também menor entre aqueles que autopercebiam sua mastigação como normal e sua saúde bucal como ruim ou muito ruim. CONCLUSÕES: O estudo identificou uma prevalência elevada da necessidade de tratamento ortodôntico em adolescentes no Brasil, associada com questões demográficas e subjetivas de saúde bucal. A alta prevalência de necessidades ortodônticas entre adolescentes é um desafio para o Sistema Único de Saúde (SUS) do Brasil.

Intramucosal nevus in the oral cavity.

AIM: The aim of this study is to report a clinical case of oral nevus. BACKGROUND: Nevus is a congenital or acquired benign neoplasia that can be observed in the skin or mucous membranes. It is an uncommon condition in the oral mucosa. When it does occur, the preferred location is on the palate, followed by the cheek mucosa, lip and tongue. CASE REPORT: In this case study, we relate the diagnosis and treatment of a 23-year-old female patient with an irregular, pigmented lesion of the oral mucosa that underwent excisional biopsy resulting in a diagnosis of intramucosal nevus. CONCLUSION: Nevus can appear in the oral mucosa and should be removed. CLINICAL SIGNIFICANCE: It is important for dental professionals to adequately categorize and treat pigmented lesions in the mouth.

[Need for orthodontic treatment among Brazilian adolescents: evaluation based on public health]. / Necessidade de tratamento ortodôntico em adolescentes brasileiros: avaliação com base na saúde pública.

OBJECTIVE: To identify the prevalence and the severity of malocclusions and to analyze factors associated with the need for orthodontic treatment of Brazilian adolescents. METHODS: This exploratory, cross-sectional study was carried out based on secondary data from the national epidemiological survey on oral health in Brazil (2002-2003). Socio-demographic conditions, self-perception, and the existence and degree of malocclusion, using the Dental Aesthetic Index, were evaluated in 16,833 adolescent Brazilians selected by probabilistic sample by conglomerates. The dependent variable - need orthodontic treatment - was estimated from the severity of malocclusion. The magnitude and direction of the association in bivariate and multivariate analyzes from a Robust Poisson regression was estimated. RESULTS: The majority of the adolescents needed orthodontic treatment (53.2%). In the multivariate analysis, the prevalence of the need for orthodontic treatment was larger among females, non-whites, those that perceived a need for treatment, and those that perceived their appearance as normal, bad, or very bad. The need for orthodontic treatment was smaller among those that lived in the Northeast and Central West macro-regions compared to those living in Southeast Brazil and it was also smaller among those that perceived their chewing to be normal or their oral health to be bad or very bad. CONCLUSIONS: There was a high prevalence of orthodontic treatment need among adolescents in Brazil and this need was associated with demographic and subjective issues. The high prevalence of orthodontic needs in adolescents is a challenge to the goals of Brazil's universal public health system.

Álcool como mediador social em universitários / Alcohol as a social mediator among university students

Identificar a prevalência do consumo de álcool em estudantes do curso de Psicologiade uma instituição de ensino superior da cidade de Montes Claros-MG. Métodos: Pesquisaquantitativa, do tipo transversal e descritiva, realizada entre os meses de setembro e outubrode 2014. A população foi constituída por 116 universitários do curso de Psicologia da cidadede Montes Claros-MG. Para a coleta de dados, foram utilizados o Teste de Identificação deDesordens Devido ao Álcool (AUDIT), o Inventário de Expectativas e Crenças PessoaisAcerca do Álcool (IECPA), o Teste de Triagem do Envolvimento com Álcool, Cigarro eOutras Substâncias (ASSIST) e a Escala de Satisfação com o Suporte Social (ESSS). Paraa análise descritiva dos dados, aplicou-se o programa SPSS, versão 19.0. Resultados: Aamostra apresentou predominância do sexo feminino (82,75%, n=96), pardos (65,51%, n=76)e solteiros (60,34%, n=70). Com relação à classificação de risco do AUDIT, constatou-se que49,13% (n=57) dos participantes da pesquisa se enquadraram no nível 4, sendo consideradosdependentes do álcool. Relataram fazer uso ocasional de fumo, álcool e outras substâncias,sendo uma classificação de nível 1 do ASSIT, com 94,82% (n= 110). Sobre o IECPA, 87,06%(n=101) dos avaliados se classificaram em nível 1, tendo baixa vulnerabilidade para os efeitosdo álcool. Tratando-se do ESSS, 68,10% (n=79) dos universitários apresentaram alto suportesocial. Conclusão: Com relação à amostra pesquisada, constatou-se alta prevalência comdependência do álcool e outras drogas, lícitas e ilícitas...

[Association between physical and psychosocial impacts of oral disorders and quality of life among the elderly]. / Associação entre impactos funcionais e psicossociais das desordens bucais e qualidade de vida entre idosos.

This study sought to evaluate the association between the impact of oral disorders in terms of physical/psychosocial dimensions and quality of life among the elderly. It involved a cross-sectional study conducted among the elderly (65-74 years) in 2008/2009. The social impact was assessed using the Oral Health Impact Profile (OHIP 14) and the quality of life using the SF 12 Short-Form Health Survey. Descriptive, univariate and multivariate (logistic regression) analysis was conducted with correction for the design effect, using SPSS(r)18.0 software. Of the 800 individuals approached, 736 elderly individuals participated (TR = 92%), with a mean age of 67.77 years, the majority of whom showed no impact based on the measurement of the prevalence of OHIP. The functional limitation dimension of the OHIP was associated with the physical domain of the SF12, irrespective of the other variables investigated. However, the seriousness of OHIP and its psychological discomfort and disability dimensions was associated with the mental domain of the SF12. The conclusion reached is that some impacts of oral disorders were associated with unsatisfactory quality of life in the physical and mental domains.

Associação entre impactos funcionais e psicossociais das desordens bucais e qualidade de vida entre idosos / Association between physical and psychosocial impacts of oral disorders and quality of life among the elderly

Objetivou-se avaliar a associação entre o impacto das desordens bucais em suas dimensões física/psicossocial e a qualidade de vida entre idosos. Estudo transversal conduzido entre idosos (65-74 anos), em 2008/2009. O impacto foi avaliado através do Oral Health Impact Profile (OHIP 14) e a qualidade de vida, através do Short-Form Health Survey SF 12. Foram realizadas análises descritivas, univariadas e múltiplas (regressões logísticas), com correção pelo efeito de desenho, utilizando-se o PASW(r) 18.0. Dos 800 convidados, participaram 736 idosos (TR = 92%), com a média de idade de 67,77 anos, a maioria não apresentou impacto, a partir da medida da prevalência do OHIP. A dimensão limitação funcional do OHIP foi associada ao domínio físico do SF12, independentemente de outras variáveis investigadas. Já a gravidade do OHIP, as suas dimensões de desconforto psicológico e deficiência, foram associadas ao domínio mental do SF12. Conclui-se que alguns impactos das desordens bucais estiveram associados a uma qualidade de vida insatisfatória em seus domínios físico e mental.

This study sought to evaluate the association between the impact of oral disorders in terms of physical/psychosocial dimensions and quality of life among the elderly. It involved a cross-sectional study conducted among the elderly (65-74 years) in 2008/2009. The social impact was assessed using the Oral Health Impact Profile (OHIP 14) and the quality of life using the SF 12 Short-Form Health Survey. Descriptive, univariate and multivariate (logistic regression) analysis was conducted with correction for the design effect, using SPSS(r)18.0 software. Of the 800 individuals approached, 736 elderly individuals participated (TR = 92%), with a mean age of 67.77 years, the majority of whom showed no impact based on the measurement of the prevalence of OHIP. The functional limitation dimension of the OHIP was associated with the physical domain of the SF12, irrespective of the other variables investigated. However, the seriousness of OHIP and its psychological discomfort and disability dimensions was associated with the mental domain of the SF12. The conclusion reached is that some impacts of oral disorders were associated with unsatisfactory quality of life in the physical and mental domains.

p16 (CDKN2A) SNP rs11515 was not associated with head and neck carcinoma.

Head and neck squamous cell carcinoma (HNSCC) is considered a serious public health problem in many countries. Recently, genetic variations have been considered as important factors to cancer susceptibility and prognosis. More specifically, genetic polymorphisms have been associated with the development and prognosis of HNSCC. The purpose of the current study was to investigate an association among p16 (CDKN2A) gene polymorphism at rs11515, age, and HNSCC aggressiveness. PCR-RFLP analysis was used to investigate the p16 (CDKN2A) gene in 96 patients with HNSCC and in 100 individuals without HNSCC. A case group was categorized by age in younger (<60 years) and older (≥ 60 years) patients. Differences between the case and control groups were determined using Fisher and chi-squared tests. Time of survival was calculated from the date of diagnosis to the date of last follow-up visit or to the date of death using the Kaplan-Meier estimator and comparing this to the log-rank test. Statistical significance was set at p<0.05. In the present study, no association was established between HNSCC and rs11515 polymorphism, as indicated in a previous study. We found that HNSCC individuals with large-sized tumors and with metastatic disease presented worse overall survival, consistent with fundamental concepts that establish the effects of tumor size and lymph node metastasis to HNSCC outcomes. This study identified that there is no difference in the distribution of rs11515 between the control and HNSCC groups. In addition, no differences between rs11515 genotypes and clinicopathological parameters were observed.

Leptin receptor polymorphism Gln223Arg (rs1137101) in oral squamous cell carcinoma and potentially malignant oral lesions.

The purpose of this study was to assess the LEPR gene Gln223Arg polymorphism (rs1137101) in oral squamous cell carcinoma (OSCC) and in potentially malignant oral lesions (PMOL) in comparison to normal oral mucosa in a Brazilian population. Smokers (n = 89) were selected from a representative sample of 471 individuals from the general population of Montes Claros, Brazil. Participants were age and gender matched to patients with OSCC (n = 25) and oral epithelial dysplasia (n = 25). We investigated the LEPR Gln223Arg polymorphism (A>G; rs1137101) in these groups. Genotype variants were assessed by RFLP-PCR, using MspI (HPAII) restriction endonuclease. The institutional review board of the Universidade Estadual de Montes Claros approved the study (process number 2667/2011). Written informed consent for this study was obtained from all participants. The GG genotype (Arg223Arg) appears to be the more relevant polymorphic variant in OSCC. It occurred, approximately, twice as frequently in OSCC patients than in the general population. In contrast, the A allele in its homozygosis form (Gln223Gln) is significantly associated with the development of PMOL; 80% of the samples from the PMOL group exhibit AA genotype. Our findings suggest new insights regarding LEPR gene variations in the development of OSCC and PMOL.

High HIF-1α expression genotypes in oral lichen planus.

OBJECTIVE: The aim of this study is to assess whether C1772T and G1790A hypoxia-inducible factor-1 (HIF-1)α polymorphisms are associated with risk of oral lichen planus (OLP). MATERIAL AND METHODS: Restriction fragment length polymorphism analysis was used to investigate HIF-1α C1779T and G1790A polymorphisms in 32 OLP and 88 individuals without OLP. RESULTS: The frequency of the CC, TT, GA, and AA genotypes was higher in patients with OLP. Notably, individuals carrying the C and A, and T and A haplotypes showed a significant association OLP risk. CONCLUSIONS: Our study demonstrated that the C1772T and G1790A polymorphisms of HIF-1α gene increased the risk of OLP. C1772T and G1790A polymorphisms of HIF-1α gene had differing patterns of allelic imbalance in the normal samples and subsequent chronic lesions. Further studies are necessary to elucidate the HIF-1α pathway in OLP, which would facilitate the development of novel therapeutic strategies for the prevention and treatment of OLP. CLINICAL RELEVANCE: These results, in conjunction with previous studies, suggest that HIF-1α may play important roles in the chronicity of oral mucosa lesions of OLP patients. Taken together, we suggest that HIF-1α polymorphisms enhance its target genes, thereby altering the microenvironment and supporting sequential release of inflammatory mediators or cellular events in OLP. It appears unlikely that inhibition of a single proinflammatory mediator will prove useful in clinical practice, but several ways to reprogram mediators engaged in a wide array of roles simultaneously are encouraging.