RESUMEN
The purpose of this study was to determine differences in somatosensation between older adults with and without type 2 diabetes among three age groups (60s, 70s, and 80s). We recruited 67 adults with type 2 diabetes and 67 age-matched adults without diabetes, aged 60-85. Data were collected using measures in Somatosensory Domain of the National Institute of Health (NIH) Toolbox. We found significant differences in the total scores of five tests examining kinesthesia, tactile sensation, and stereognosis among the three age groups. For all significant differences, the nondiabetes group and those in their 60s and 70s had better functioning than the diabetes group and those in their 80s. The NIH Toolbox-Somatosensory Tools used in this study may be more suitable to discriminate among age groups rather than diagnostic groups.
Asunto(s)
Envejecimiento/fisiología , Diabetes Mellitus Tipo 2/complicaciones , Neuropatías Diabéticas/diagnóstico , Neuropatías Diabéticas/etiología , Trastornos Somatosensoriales/diagnóstico , Trastornos Somatosensoriales/etiología , Factores de Edad , Anciano , Anciano de 80 o más Años , Australia , Femenino , Humanos , Kansas , Masculino , Persona de Mediana Edad , Ohio , PennsylvaniaRESUMEN
Diaminedithiol (DADT) or N-monosubstituted DADT is known to form lipophilic neutral chelates with technetium. As a result, they are used for brain imaging agents. However, 99mTc-N,N'-dimethylDADT has been demonstrated to have a positive charge and a lower lipophilicity (log P = 0.1) in this experiment. The results of a biodistribution study showed that most activity was found in the intestine after 1 hr, which is the evidence of bile excretion. Increased heart-uptake in mice suggests that this compound or its derivatives can be used as a myocardial-imaging agent.
