1.
Nat Rev Drug Discov
; 21(4): 245-246, 2022 04.
Artículo
en Inglés
| MEDLINE
| ID: mdl-34907316
2.
Org Lett
; 4(4): 643-6, 2002 Feb 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11843612
RESUMEN
[reaction: see text] An approach to the macrocyclic core of apicularen A is described. Thus, cross-coupling of the aryl triflate 7 with the vinylstannane 19 provided the styrene 20. Deprotection led to the dihydroxy acid 22. Through a size-selective macrolactonization, the 12-membered macrolactone 23 was obtained. Treatment of 24 with N-phenyl selenophthalimide gave the desired trans-pyran 24. This approach might parallel the biosynthetic pathway.