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1.
Folia Med Cracov ; 62(2): 93-107, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36256897

RESUMEN

Tenosynovial Giant Cell Tumor (TGCT) is a group of typically benign lesions arising from the synovium of joints, bursae and tendon sheaths. Depending on their growth pattern and clinical course, they are divided into localized and diffuse types. It is predominantly caused by a mutation in the stromal cells of the synovial membrane leading to overexpression of the colony stimulating factor 1 that recruits CSF1R-expressing cells of the mononuclear phagocyte lineage into the tumor mass. The lesions contain mainly histiocyte-like and synovial cells accompanied by varying numbers of multinucleated giant cells, mononuclear cells, foam cells, inflammatory cells and hemosiderin deposits. The gold standard for detect- ing and monitoring the disease is MRI, where the characteristic hemosiderin accumulation can be best appreciated, but it is a histological examination that is most conclusive. The main treatment is surgical resection of all pathological tissue, but radio- and chemotherapy are also viable options for certain groups of patients.


Asunto(s)
Tumor de Células Gigantes de las Vainas Tendinosas , Tumores de Células Gigantes , Sinovitis Pigmentada Vellonodular , Humanos , Sinovitis Pigmentada Vellonodular/terapia , Factor Estimulante de Colonias de Macrófagos/genética , Factor Estimulante de Colonias de Macrófagos/uso terapéutico , Tumores de Células Gigantes/tratamiento farmacológico , Tumores de Células Gigantes/patología , Tumores de Células Gigantes/cirugía , Hemosiderina/uso terapéutico
2.
Folia Med Cracov ; 61(3): 33-42, 2021 Sep 29.
Artículo en Inglés | MEDLINE | ID: mdl-34882662

RESUMEN

Memory trace is an effect of temporary arousal (perception, experience, action) that causes a specific change in the nervous system. Memory allows to record and recall various information, thus enabling to learn new things. It is an extremely active and dynamic process. The influence of emotions on memory is obvious, largely determined by the close cooperation of the amygdala (responsible for emotions) and the hippocampus (memory processes).


Asunto(s)
Nivel de Alerta , Memoria , Amígdala del Cerebelo , Emociones , Humanos
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