RESUMEN
A new series of new hetero-bimetallic complexes containing iron and ruthenium of the general formula [RuCl(CO)(B)(EPh3)(L)] (where E=P or As; B=PPh3, AsPh3, py or pip; L=ferrocene derived monobasic bidentate thiosemicarbazone ligand) have been synthesized by the reaction between ferrocene-derived thiosemicarbazones and ruthenium(II) complexes of the type [RuHCl(CO)(B)(EPh3)2] (where E=P or As; B=PPh3, AsPh3, py or pip). The new complexes have been characterized by elemental analyses, IR, electronic, NMR (1H, 13C and 31P), EXAFS (extended X-ray absorption fine structure spectroscopy) and cyclic voltammetric techniques. Antibacterial activity of the new complexes has been screened against Escherichia coli, Vibrio cholerae, and Pseudomonas aeruginosa species.
Asunto(s)
Arsenicales/farmacología , Técnicas Electroquímicas/métodos , Compuestos Ferrosos/química , Compuestos Organofosforados/farmacología , Rutenio/farmacología , Tiosemicarbazonas/farmacología , Espectroscopía de Absorción de Rayos X , Antibacterianos/química , Antibacterianos/farmacología , Arsenicales/química , Escherichia coli/efectos de los fármacos , Ligandos , Espectroscopía de Resonancia Magnética , Pruebas de Sensibilidad Microbiana , Compuestos Organofosforados/química , Pseudomonas aeruginosa/efectos de los fármacos , Bases de Schiff , Espectroscopía Infrarroja por Transformada de Fourier , Tiosemicarbazonas/química , Vibrio cholerae/efectos de los fármacosRESUMEN
The reactions of [RuHCl(CO)(PPh3)2(B)] (B = PPh3, pyridine or piperidine) and 2'-hydroxychalcones led to the formation of [RuCl(CO)(PPh3)(L)(B)] (L = chalconate). The new complexes have been characterized by analytical and spectral (IR, electronic, 1H NMR and 31P NMR) data. They have been assigned an octahedral structure. The complexes have been used as catalysts for the aerial oxidation of cinnamyl alcohol. Some of the complexes have been tested in vitro for growth inhibitory activity against the bacteria E. coli, S. typhi and Pseudomonas sp. and the fungi A. fumigatus.
