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Bioorg Med Chem Lett
; 12(18): 2515-8, 2002 Sep 16.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12182850
RESUMEN
A series of novel spiroketal-based NK(1) antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.