Coccidioides immitis: A Rare Form of the Disease Process Presenting in an Even Rarer Location.

ABSTRACT: Coccidioides immitis is a dimorphic fungus, growing as a fungus in the soil and as a yeast in the human body, that is geographically limited in the United States, being most commonly associated with the San Joaquin Valley and found in California and Arizona. In most individuals, infection with C. immitis causes an asymptomatic, self-limited pulmonary infection; however, in a small percentage of individuals, the infection is disseminated and can involve any organ. We present the case of a 50-year-old man who was found unresponsive in his home in the northern portion of the United States. Autopsy revealed a 2163-g spleen. The initial differential diagnosis for the splenomegaly was an infection or a neoplastic process, such as leukemia. Because of the geographic location where the body was found, C. immitis was not initially considered; however, microscopic examination confirmed the presence of C. immitis spherules, which were found in the spleen and other organs. Granulomatous inflammation, often associated with spherules, was also present in a kidney, the pancreas, the thyroid gland, a parathyroid gland, and the heart. Additional investigation after the autopsy revealed that the decedent had spent time in the past in California, which would have allowed for exposure to C. immitis. The decedent had a rare form of a disease process not normally associated with the geographic location in which he was found, which highlights the need for continued diligence in death investigation so as to not allow a first impression to impair the correct final determination.

Educational Case: Hereditary Colorectal Cancer and Association With Endometrial Carcinoma.

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040. 1.

Postmortem Diagnosis of Clostridium Without Culture Confirmation.

ABSTRACT: We report 3 individuals with clostridial sepsis, 2 culture-confirmed and 1 assumed based on historical information and autopsy findings. Case 1: a 46-year-old man with history of colon cancer status postcolectomy was found unresponsive and rapidly developed decompositional changes. At autopsy, within 1 day of his death, he had marked gaseous distention of the scrotum and palpable crepitance from the eyes to the feet, with bullae formation in the suprapubic region and left thigh. Postmortem culture of bullae fluid grew Clostridium septicum. Case 2: a 63-year-old woman with history of non-Hodgkin's lymphoma who was identified to have Clostridium perfringens by hospital cultures. Autopsy was performed the day after death. The skin had a generalized red-tan discoloration. The liver had large gas pockets in the parenchyma. Microscopic examination revealed bacterial rods. Other than diverticulosis and mild coronary artery atherosclerosis, no other disease process was identified. Case 3: a 34-year-old man was found dead in his apartment, which was 68°F, just under 1 day after having last been known alive. He was cooled before autopsy and autopsied less than 24 hours after being found. He had fixed anterior lividity, an abdomen that was distended by gas formation, and a scrotum that was distended by gas formation. There was no green discoloration of the abdomen. Glomerular capillaries contained bacterial rods with terminal spores. Because no other cause was identified, the cause of death was certified as probable clostridial sepsis.

Educational Case: Aortic Valve Stenosis.

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.

An Inflamed, Giant, True, Extramural Duodenal Diverticulum: A Rare Autopsy Finding.

A 53-year-old man was found to have a giant 16 × 6-cm hemorrhagic and cystic mass centered on the pancreas and duodenum. Initially diagnosed as a pancreatic pseudocyst at the time of autopsy, the cystic mass was later determined by histologic examination to be a true diverticulum of the duodenum as microscopic examination of the wall revealed 2 layers of muscle, as well as a neutrophilic infiltrate. While the cause of death of the individual was certified as methamphetamine toxicity, cardiomegaly and probable dehydration associated with a giant duodenal diverticulum were listed as contributory conditions. While duodenal diverticula in general are relatively uncommon findings, an extramural, true, giant duodenal diverticulum that is inflamed is a rare clinical or autopsy finding, with only 2 case reports identified in the clinical medical literature and none in the forensic literature.

Homicide-Suicide: A Homicidal Asphyxiation Misinterpreted as a Gunshot Wound at the Scene.

Strangulation is commonly associated with certain findings at autopsy, including petechial hemorrhages in the conjunctiva and oral mucosa, contusions or abrasions of the neck, hemorrhage within the anterior and posterior neck musculature, and fractures of the hyoid bone or thyroid cartilage. We present the case of a 68-year-old woman who was found dead in her bedroom, with her husband being found dead in the garage. Her husband had shot himself, and the woman, who was lying partially on her side, had blood coming from her ear that was facing upward and was, at the scene, also believed to have been shot. Autopsy revealed no gunshot wound, but instead florid petechial hemorrhages of the face and conjunctivae, a few contusions of the left and right sides of the neck, a laceration of the lower lip, oral mucosal petechiae, focal hemorrhage in the soft tissue around the hyoid bone, and focal hemorrhages in the left and right sternohyoid muscle. The tongue had multiple contusions. Her cause of death was certified as homicidal asphyxiation, including probable strangulation. Extensive contusions of the tongue are not routine findings with strangulation but occur in about 25% of cases, especially those involving the elderly, and hemorrhage from the ear is rarely reported. This case illustrates uncommon and rare autopsy findings for strangulation, which under the right circumstances, deceived investigators into thinking that a gunshot wound had occurred.

A Comparison of Coronary Artery Stenosis Estimates Made by Forensic Pathologists and Medical Students.

Previous studies suggest cardiovascular pathologists are less accurate than noncardiovascular pathologists (e.g., clinical pathologists) in estimating the degree of coronary artery stenosis. To further investigate the effect of training on accurate estimation of coronary artery stenosis, we designed a study to compare the accuracy of estimates made by forensic pathologists versus medical students. Six forensic pathologists and twelve medical students each independently examined 24 images of coronary artery cross sections and gave an estimate of the degree of stenosis. When comparing all 24 images, the forensic pathologists had a median difference between the estimated percentage of stenosis and actual percentage of stenosis of -12.380 and the medical students had a median difference of -16.50 (p-value of 0.08542). In estimating the percentage of stenosis, training in forensic pathology does not guarantee significantly improved accuracy compared with medical students. Our study showed no consistent statistically significant difference between estimates given by forensic pathologists and by medical students.

Challenges in the Diagnosis of a Posterior Lingual Abscess, a Potential Lethal Disorder: A Case Report and Review of the Literature.

A lingual abscess is a rare but potentially life-threatening disorder. Since the introduction of antibiotics, the incidence of posterior lingual abscesses has significantly declined; however, this condition is often missed on physical examination or misdiagnosed as another condition. The consequence of this misdiagnosis can be severe because airway obstruction with subsequent difficult or unattainable intubation can develop and lead rapidly to death. Being relatively rare yet potentially lethal, consideration of a lingual abscess at the time of autopsy is important; otherwise, it may be missed. During most autopsies, the base of the tongue is often examined grossly in a cursory fashion, if at all, and microscopic sections of this region are not commonly used. As this case report will illustrate, such an approach would most likely miss this important condition.

Right Ventricle Rupture After Open Heart Surgery.

The potential complications of cardiac surgery with sternotomy include mediastinitis and major bleeding, events that are infrequent but carry high mortality.We report a unique complication of median sternotomy. A 71-year-old man underwent coronary artery bypass grafting complicated by sternal dehiscence on postoperative day 7. One week after discharge, he presented with purulent drainage from the sternal wound bed and was diagnosed as having mediastinitis. Irrigation, debridement, and sternal reconstruction were performed. Two days later, bleeding was observed in the wound, and during surgical exploration, a tear in the right ventricle was discovered, and the patient exsanguinated and died. Autopsy findings included focal adhesions connecting the posterior sternum to the right ventricle wall, as well as microscopic evidence of focally extensive fatty infiltration along the rupture margin of the myocardium.Pertinent aspects of the case are reviewed, with particular attention to the possible microbial etiology of mediastinal infection and most likely mechanisms of injury contributing to the fatal right ventricular rupture.

Forensic Autopsy Experience and Core Entrustable Professional Activities: A Structured Introduction to Autopsy Pathology for Preclinical Student.

The forensic and autopsy pathology service within the Department of Pathology at University of North Dakota School of Medicine provides an optional, structured autopsy experience for medical students during the second year of the curriculum. This experience reinforces forensic autopsy pathology as the practice of medicine and highlights the American Association of Medical Colleges Core Entrustable Professional Activities. Students self-select for this optional, noncredit autopsy observership. Prior to the experience, interested students participate in a session that reviews the professional and educational expectations of the autopsy experience, autopsy safety training, and logistics of call. Groups of up to 4 students are on call for an autopsy. Student groups observe and participate in an autopsy, ideally from scene through autopsy performance, slide review, and toxicology results. The student groups use a structured presentation format for summarizing their autopsy experience, forming a differential and final diagnosis, completing the death certificate, and discussing quality management or learning issues in the case. At the end of the semester, all students participating in the experience meet and each group presents a 10-minute, structured review of their case. At least 6 core entrustable professional activities were addressed in every autopsy review; some had more when advanced clinical questions or safety issues were identified. Additionally, one student presented his case at a national meeting with a resultant publication. The experience provided (1) a positive introduction to autopsy pathology, (2) reinforced the role of pathology in medicine, and (3) provided concrete examples of American Association of Medical Colleges Core Entrustable Professional Activities within pathology for students in preclinical years.

Fatality While Bear Hunting: A Homicide or an Accident?

When a hunter intentionally fires a weapon and the projectile strikes another human, the manner of death is most often certified as a homicide. The intent of the individual firing the weapon is unknown and the possibility that a hunting "accident" represents a concealed intentional homicide must always be considered. However, in some circumstances such as a documented ricochet, the manner of death may be certified as accident.The death of a hunter who was being mauled by a grizzly bear and subsequently died will be presented. While the man had injuries from the mauling, these injuries were, with treatment, survivable; however, he also had a gunshot wound of the left shoulder into the trunk. His partner had shot the bear, but unfortunately, 1 projectile perforated the bear and struck the decedent.According to the National Association of Medical Examiners' Guide for Manner of Death Classification, if a hunter intentionally fires a weapon and kills a human the manner of death may be classified as homicide; however, if a weapon is discharged and the projectile strikes an object, ricochets, and kills a human, the manner of death may be classified as accident. In the death reported, the scenario does not exactly fit either of the above 2 situations. In this current case, given that (1) the decedent's friend fired a projectile with an intent to hit the bear that was mauling his partner and (2) that the projectile perforating the bear and entering his partner was unintended, the manner of death was certified as accident.

Delayed Death Due to Saddle Pulmonary Thromboembolus in Child With Nephrotic Syndrome Induced by Focal Segmental Glomerulosclerosis.

While the characteristic features of nephrotic syndrome (ie, proteinuria, hypoalbuminemia, peripheral edema, and hyperlipidemia) are well known, the association of nephrotic syndrome and the risk of thromboembolic events is not as often appreciated and may be overlooked. This report describes a 10-year-old boy with focal segmental glomerulosclerosis who died following a saddle pulmonary thromboembolus, with near-complete occlusion of the left and right pulmonary arteries. The gross appearance of the thrombus suggested organization and histologic changes within the wall of the pulmonary artery indicated a period of at least 3 or more hours to a few days since the event occurred. Pulmonary thromboemboli in children are rare, and the number of cases in the medical literature discussing the occurrence of pulmonary thromboemboli in the background of renal disease in children is relatively small, and none apparently clearly describe saddle thromboemboli with a delay from time of occurrence until death. This case report serves as a good reminder for forensic pathologists to consider renal disease as an underlying etiology for pulmonary thromboembolus and how histologic features of the pulmonary artery may help determine a time frame for the event.

Acute Subdural Hemorrhage Associated With Both Metastatic Adenocarcinoma of the Dura and Minor Head Trauma: A Case Report and Review of the Literature.

While reportedly a relatively common finding at the autopsy of decedents with metastatic neoplasms, dural metastases are infrequently described in the medical literature and only 55 cases of subdural hemorrhage associated with dural metastases have been described, with only one of these cases associated with head trauma. We report a 50-year-old incarcerated male who died as the result of acute and chronic subdural hemorrhage associated with recent minor head trauma and dural metastases, which were most likely of pancreatic origin. He had sustained a fall, possibly due to a seizure in his jail cell, developed an acute subdural hemorrhage, and died, necessitating an autopsy. Metastatic tumor in the dura and other organs was identified upon histologic examination and found to be CK7 and CK20 positive and TTF-1 and CDX2 negative, consistent with a pancreatic adenocarcinoma. In addition, marantic endocarditis was identified, which can occur in individuals with mucinous tumors, such as a pancreatic neoplasm. This case report offers the second description of a subdural hemorrhage occurring in association with both dural metastases and recent head trauma and confirms the importance of histologic examination of the subdural hemorrhage and adjacent dura at autopsy for reasons other than just timing of the event.

Pancreatic Islet Hyperplasia: A Potential Marker for Anabolic-Androgenic Steroid Use.

It has been estimated that up to four million Americans have used anabolic-androgenic steroids (AAS) to increase muscle mass - either for improved athletic performance, enhanced personal appearance, or both. While the pathologic effects of supra-physiologic doses of AAS have been well-described for some organ systems, such as the cardiovascular system, the effects on other organ systems are less well-described; for example, there is a dearth of knowledge in the medical literature regarding the effects of recreational use of AAS on the islet cells of the endocrine pancreas. As pancreatic islet hyperplasia has previously been described in the literature in a group of patients receiving long-term AAS treatment for Fanconi anemia, it is reasonable to suggest that the use of AAS by bodybuilders could produce the same (or similar) histologic changes. We present a case that offers support for the association of anabolic-androgenic steroid use and pancreatic islet hyperplasia.