Microbial production of keratinase from Bacillus velezensis strain MAMA: A novel enzyme for eco-friendly degradation of keratin waste.

Keratin waste has become an increasingly serious environmental and health hazard. Keratin waste is mainly composed of keratin protein, which is one of the most difficult polymers to break down in nature and is resistant to many physical, chemical, and biological agents. With physical and chemical methods being environment damaging and costly, microbial degradation of keratin using keratinase enzyme is of great significance as it is both environment friendly and cost-effective. The aim of this study was to extract and purify keratinase from bacterial species isolated from the soil. Among the organisms, an isolate of Bacillus velezensis, coded as MAMA could break down chicken feathers within 72 hours (h). The isolated strain produced significant levels of keratinase in mineral salt medium by supplying chicken feathers as the sole source of nitrogen and carbon. Feather deterioration was observed with the naked eye, and enzyme activity was evaluated using a spectrophotometric assay. Sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and zymography results revealed that the keratinase protein produced by Bacillus velezensis had a molecular weight between 40 and 55 kilodalton (kDa).

Management of Ischemic Stroke in a Tertiary Care Hospital in Khyber Pakhtunkhwa: Existing Status and Prospective Opportunities.

Background and objective Khyber Pakhtunkhwa is the third largest province of Pakistan by population and has a high incidence of ischemic stroke. We evaluated all patients who presented to the largest tertiary care facility in the province to learn about the current trends in the management of ischemic stroke and explore future opportunities in this regard.  Materials and methods This prospective observational research was carried out at the Lady Reading Hospital-Medical Teaching Institute (LRH-MTI), Peshawar, in the province of Khyber Pakhtunkhwa (KP). The hospital's ethics committee granted the required permissions for the research. Any patient with an ischemic stroke diagnosis, regardless of age, met the inclusion criteria if their diagnosis was confirmed by clinical assessment, imaging (such as CT or MRI), or both. The clinical parameters that were evaluated included the duration since the patient's reported onset of symptoms, the patient's first mode of transfer to the hospital (such as ambulance, private vehicle, or other means), and the date and time of admission to the hospital. A structured database containing the data was utilized, and IBM SPSS Statistics for Windows, Version 25 (released 2017; IBM Corp., Armonk, New York, United States) was used for statistical analysis. Results One hundred fifty-six stroke patients were diagnosed throughout the study period, with 76 of them having an ischemic stroke, accounting for 49% of all stroke cases. Approximately 43% (n = 33) of the patients were from Peshawar, with the remaining patients coming from adjacent districts. There was only a small percentage (19%, n = 15) of patients who were eligible for any thrombolytic therapy, and the majority (93%) were brought by private vehicles. There was a significant association between age and arrival in the emergency room (p = 0.003). Conclusion The study reveals subpar ischemic stroke management in Khyber Pakhtunkhwa, requiring coordinated efforts, modernization of treatment methods, and increased public awareness to improve patient outcomes.

Effect of boundary slips and magnetohydrodynamics on peristaltic mechanism of Jeffrey nanofluid along with microorganisms through a porous medium.

The development on entropy generation in fluid flows has applications in many medical equipment such as cryogenic devices and therapeutic heat apparatus. This study looks at how porous medium, multi-slips, and entropy formation affect the pumping of Jeffrey nanofluid flow through an asymmetric channel containing motile microorganims. A lubrication theory is used to neglect the fluctuation effects in the flow. Numerical simulations are utilized to generate data for specific physical features of the problem utilizing the Shooting approach on Mathematica. Following a thorough research, it is appropriate to conclude that the porous medium's permeability reduces flow speed along the walls while increases at the center of the flow region. Graphical representation of the results further reveals that entropy production can be decreased by including high thermal slip and low viscous slip elements. It is also worth noting that the Brinkman number reduces the thermal distribution in the flow while it helps in increasing the flow speed.

Advanced stability analysis of a fractional delay differential system with stochastic phenomena using spectral collocation method.

In recent years, there has been a growing interest in incorporating fractional calculus into stochastic delay systems due to its ability to model complex phenomena with uncertainties and memory effects. The fractional stochastic delay differential equations are conventional in modeling such complex dynamical systems around various applied fields. The present study addresses a novel spectral approach to demonstrate the stability behavior and numerical solution of the systems characterized by stochasticity along with fractional derivatives and time delay. By bridging the gap between fractional calculus, stochastic processes, and spectral analysis, this work contributes to the field of fractional dynamics and enriches the toolbox of analytical tools available for investigating the stability of systems with delays and uncertainties. To illustrate the practical implications and validate the theoretical findings of our approach, some numerical simulations are presented.

A novel approach towards web browser using the concept of a complex spherical fuzzy soft information.

The modern technology is the practical application of scientific knowledge, whether in industry or daily life, for goals or purposes. More quickly than any other technological advancement in human history, digital technologies have advanced. The technology sector is expanding and provides both new educational opportunities and innovative, exciting products. Right now, one of the most widely used and fascinating technologies is the web browser. This article introduced the novel concepts of complex spherical fuzzy soft relations (CSFSRs) by using the Cartesian Product (CP) of two complex spherical fuzzy soft sets (CSFSSs). Additionally, examples are used to clarify various types of relations. Because it discusses all levels of membership, abstinence, and non-membership with multidimensional variables, the CSFSRs have a detailed structure. The CSFSR-based modelling tools developed in this research, which primarily rely on the score function, can be used to choose the best Web browser. The transaction could be as easy as users sharing records via a functional web browser. Finally, the advantages of this suggested structure are illustrated by contrasting it with alternative structures.

A novel simulation-based analysis of a stochastic HIV model with the time delay using high order spectral collocation technique.

The economic impact of Human Immunodeficiency Virus (HIV) goes beyond individual levels and it has a significant influence on communities and nations worldwide. Studying the transmission patterns in HIV dynamics is crucial for understanding the tracking behavior and informing policymakers about the possible control of this viral infection. Various approaches have been adopted to explore how the virus interacts with the immune system. Models involving differential equations with delays have become prevalent across various scientific and technical domains over the past few decades. In this study, we present a novel mathematical model comprising a system of delay differential equations to describe the dynamics of intramural HIV infection. The model characterizes three distinct cell sub-populations and the HIV virus. By incorporating time delay between the viral entry into target cells and the subsequent production of new virions, our model provides a comprehensive understanding of the infection process. Our study focuses on investigating the stability of two crucial equilibrium states the infection-free and endemic equilibriums. To analyze the infection-free equilibrium, we utilize the LaSalle invariance principle. Further, we prove that if reproduction is less than unity, the disease free equilibrium is locally and globally asymptotically stable. To ensure numerical accuracy and preservation of essential properties from the continuous mathematical model, we use a spectral scheme having a higher-order accuracy. This scheme effectively captures the underlying dynamics and enables efficient numerical simulations.

Functionalized Single Crystal Perovskite Materials for SERS and Their Potential Detection Applications.

Recent advances in detection and diagnostic tools have improved understanding and identification of plant physiological and biochemical processes. Effective and safe Surface Enhanced Raman Spectroscopy (SERS) can find objects quickly and accurately. Raman enhancement amplifies the signal by 1014-1015 to accurately quantify plant metabolites at the molecular level. This paper shows how to use functionalized perovskite substrates for SERS. These perovskite substrates have lots of surface area, intense Raman scattering, and high sensitivity and specificity. These properties eliminate sample matrix component interference. This study identified research gaps on perovskite substrates' effectiveness, precision, and efficiency in biological metabolite detection compared to conventional substrates. This article details the synthesis and use of functionalized perovskites for plant metabolites measurement. It analyzes their pros and cons in this context. The manuscript analyzes perovskite-based SERS substrates, including single-crystalline perovskites with enhanced optoelectronic properties. This manuscript aims to identify this study gap by comprehensively reviewing the literature and using it to investigate plant metabolite detection in future studies.

A fuel gas waste heat recovery-based multigeneration plant integrated with a LNG cold energy process, a water desalination unit, and a CO2 separation process.

Development of the multigeneration plants based on the simultaneous production of water and energy can solve many of the current problems of these two major fields. In addition, the integration of fossil power plants with waste heat recovery processes in order to prevent the release of pollutants in the environment can simultaneously cover the environmental and thermodynamic improvements. Besides, the addition of a carbon dioxide (CO2) capturing cycles with such plants is a key issue towards a sustainable environment. Accordingly, a novel waste heat recovery-based multigeneration plant integrated with a carbon dioxide separation/liquefaction cycle is proposed and investigated under multi-variable assessments (energy/exergy, financial, and environmental). The offered multigeneration system is able to generate various beneficial outputs (electricity, liquefied CO2 (L-CO2), natural gas (NG), and freshwater). In the offered system, the liquified natural gas (LNG) cold energy is used to carry out condensation processes, which is a relatively new idea. Based on the results, the outputs rates of net power, NG, L-CO2, and water were determined to be approximately 42.72 MW and 18.01E+03, 612 and 3.56E+03 kmol/h, respectively. Moreover, the multigeneration plant was efficient about 32.08% and 87.72%, respectively, in terms of energy and exergy. Economic estimates indicated that the unit product costs of electricity and liquefied carbon dioxide production, respectively, were around 0.0466 USD per kWh and 0.0728 USD per kg-CO2. Finally, the total released CO2 was about 0.034 kg per kWh. According to a comprehensive comparison, the offered multigeneration plant can provide superior environmental, thermodynamic, and economic performances compared to similar plants. Moreover, there was no need to purchase electricity from the grid.

Numerical simulation of a fractional stochastic delay differential equations using spectral scheme: a comprehensive stability analysis.

The fractional stochastic delay differential equation (FSDDE) is a powerful mathematical tool for modeling complex systems that exhibit both fractional order dynamics and stochasticity with time delays. The purpose of this study is to explore the stability analysis of a system of FSDDEs. Our study emphasizes the interaction between fractional calculus, stochasticity, and time delays in understanding the stability of such systems. Analyzing the moments of the system's solutions, we investigate stochasticity's influence on FSDDS. The article provides practical insight into solving FSDDS efficiently using various numerical techniques. Additionally, this research focuses both on asymptotic as well as Lyapunov stability of FSDDS. The local stability conditions are clearly presented and also the effects of a fractional orders with delay on the stability properties are examine. Through a comprehensive test of a stability criteria, practical examples and numerical simulations we demonstrate the complexity and challenges concern with the analyzing FSDDEs.

Enhancing soot oxidation using microtextured surfaces.

Biomass combustion provides energy needs for millions of people worldwide. However, soot accumulation on the combustors' walls significantly reduces heat transfer efficiency. Herein, we demonstrate how microtextured surfaces minimize soot accumulation by enhancing soot oxidation. We investigate soot layers from the combustion of paraffin wax as a model for wood-based soot, and find that randomly microtextured glass obtained by sandblasting shows a 71% reduction in the time taken to oxidize 90% of surface soot coverage when compared to smooth glass at 530 °C. We also study grooved microtextures fabricated via laser ablation and find that grooves with widths between 15 and 50 µm enhance soot oxidation, while the expedited advantage is lost when the groove width is 85 µm. X-ray photoelectron spectroscopy validates the superior extent of soot removal on microtextures down to a sub-nanometer length-scale. The high density of sharp features such as peaks and edges on microtextures, and the conformality of the soot layer to the microtextures contribute to increased soot oxidation. We also demonstrate enhanced soot oxidation on microtextured stainless steel, the principal material of construction in biomass combustors. Microtextured surfaces that facilitate soot oxidation upon contact could significantly improve performance and longevity in various combustion applications.

Advancing COVID-19 stochastic modeling: a comprehensive examination integrating vaccination classes through higher-order spectral scheme analysis.

This research article presents a comprehensive analysis aimed at enhancing the stochastic modeling of COVID-19 dynamics by incorporating vaccination classes through a higher-order spectral scheme. The ongoing COVID-19 pandemic has underscored the critical need for accurate and adaptable modeling techniques to inform public health interventions. In this study, we introduce a novel approach that integrates various vaccination classes into a stochastic model to provide a more nuanced understanding of disease transmission dynamics. We employ a higher-order spectral scheme to capture complex interactions between different population groups, vaccination statuses, and disease parameters. Our analysis not only enhances the predictive accuracy of COVID-19 modeling but also facilitates the exploration of various vaccination strategies and their impact on disease control. The findings of this study hold significant implications for optimizing vaccination campaigns and guiding policy decisions in the ongoing battle against the COVID-19 pandemic.

Return to Play After Surgical Treatment for Acromioclavicular Joint Dislocation: A Systematic Review.

BACKGROUND: Acromioclavicular (AC) joint dislocation is a common clinical problem among young and athletic populations. Surgical management is widely used for high-grade dislocations (Rockwood III-VI) and in high-demand athletes at high risk of recurrence. PURPOSE: To systematically review the evidence in the literature to ascertain the rate and timing of return to play (RTP) and the availability of specific criteria for safe RTP after surgical treatment for AC joint dislocation. STUDY DESIGN: Systematic review; Level of evidence, 4. METHODS: A systematic literature search based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was conducted in the PubMed database. Clinical studies were eligible for inclusion if they reported on RTP after surgical treatment for AC joint dislocation. Statistical analysis was performed with SPSS. RESULTS: We found 120 studies including 4327 cases meeting our inclusion criteria. The majority of patients were male (80.2%), with a mean age of 37.2 years (range, 15-85) and a mean follow-up of 34.5 months. Most were recreational athletes (79%), and the most common sport was cycling. The overall rate of RTP was 91.5%, with 85.6% returning to the same level of play. Among collision athletes, the rate of RTP was 97.3%, with 97.2% returning to the same level of play. In overhead athletes, the rate of RTP was 97.1%, with 79.2% returning to the same level of play. The mean time to RTP was 5.7 months (range, 1.5-15). Specific RTP criteria were reported in the majority of the studies (83.3%); time to return to play was the most commonly reported item (83.3%). Type III Rockwood injuries had the highest RTP rate at 98.7% and the earliest RTP at 4.9 months. Among the different surgical techniques, Kirschner wire fixation had the highest rate of RTP at 98.5%, while isolated graft reconstruction had the earliest RTP at 3.6 months. CONCLUSION: The overall rate of RTP was reportedly high after surgical treatment for AC joint dislocation, with the majority of patients returning to their preinjury levels of sport. There is a lack of consensus in the literature for what constitutes a safe RTP, with further focus on this topic required in future studies.

Young Collision Athletes Have High Rate of Return to Play and Good Clinical Outcomes Following Open Latarjet Procedure.

PURPOSE: To evaluate return to play (RTP), clinical outcomes, and recurrence rates in collision athletes 20 years of age and younger who underwent open Latarjet for anterior shoulder instability. METHODS: A retrospective review of collision athletes 20 years of age and younger, who underwent an open Latarjet procedure by a single surgeon between the years of 2010-2020 was carried out. Inclusion criteria were 1) collision athlete, 2) underwent open Latarjet procedure, 3) 16-20 years old, and 4) minimum 24-month follow-up. Exclusion criteria were 1) other pathology of the ipsilateral shoulder and 2) noncollision athlete. Rate of RTP, time to RTP, rate of return to preinjury level, the Shoulder Instability Return to Sport after Injury score (SIRSI) score, Subjective Shoulder Value (SSV), visual analogue scale (VAS) scores, and recurrence events were recorded. Quantitative statistical analysis was carried out. RESULTS: The study included 105 male collision athletes with a mean age of 18.6 ± 1.0 years (range: 17-20). The mean follow-up for patients was 36 ± 26.2 months. A total of 93 (88.6%) RTP at a mean time of 6.3 ± 2.2 months, with 73 (69.5%) returning to their preinjury level of participation. The mean SIRSI score was 69.2 ± 21.8, the mean VAS score was 2.3 ± 2.1, and the mean SSV score was 84.1 ± 16.8. Five patients (4.8%) redislocated their shoulder, with 4 of these requiring a further surgery (3.8%). Two patients (1.9%) reported incidents of subluxation. CONCLUSIONS: The open Latarjet procedure in young collision athletes results in high rates of RTP, excellent functional outcomes and low recurrence rates at mid-term follow-up. Additionally, complication rates are low in this cohort. LEVEL OF EVIDENCE: Level IV, case series.

Salmonella meningitis in a young child from Pakistan: a case report.

BACKGROUND: Salmonella meningitis is a rare but serious complication of Salmonella infection, primarily affecting infants, children, and immunocompromised individuals. CASE PRESENTATION: We present a case of a two-and-a-half-year-old Asian boy who developed Salmonella meningitis along with pneumonia and respiratory failure. Initially, he experienced symptoms of loose motions, fever, and irritability, which progressed to neck stiffness and brisk reflexes. Cerebrospinal fluid (CSF) analysis confirmed Salmonella typhi in the CSF. Due to the worsening condition, the patient was admitted to the intensive care unit, intubated, and switched to meropenem as the antibiotic of choice after an initial empiric therapy with ceftriaxone and vancomycin. With appropriate treatment, the patient showed significant improvement, including resolution of fever and respiratory symptoms. CONCLUSION: Management of Salmonella meningitis is often challenging primarily because of the fact that the empiric therapy for meningitis may not always provide coverage to the multi-drug resistant Salmonella species found in South Asia. Prompt administration of appropriate antibiotics based on sensitivity testing is crucial for successful management. This case emphasizes the importance of early recognition and effective management of this uncommon yet severe complication of Salmonella infection.

Posterior Shoulder Instability but Not Anterior Shoulder Instability Is Related to Glenoid Version.

Purpose: To assess and compare glenoid version in patients with anterior shoulder instability (ASI), posterior shoulder instability (PSI), and a control group. Methods: The operative notes of all patients that had undergone arthroscopic shoulder instability repair between January 2017 and May 2022 were retrospectively reviewed. Magnetic resonance imaging scans were then analyzed, and glenoid version was measured by a single blinded observer. A P value <.05 was considered statistically significant. Results: There were 100 patients included in the ASI group, 65 in PSI group, and 100 in the control group. The mean glenoid versions for the ASI group were -16°, -9.1°, and -9.2° for the vault version, simplified vault version, and chondrolabral version, respectively. The mean glenoid versions for the PSI group were -21°, -13.4°, and -16.6° for the vault version, simplified vault version, and chondrolabral version, respectively. The mean versions for the control group were -17.8°, -9.5°, and -9.8° for the vault version, simplified vault version and chondrolabral version, respectively. ANOVA testing and post hoc comparisons revealed the PSI group to be significantly more retroverted than both other groups P < .001. The ASI group's degree of glenoid version was not significantly different to that of the control P = .009. Conclusion: Patients with PSI have a higher degree of retroversion in comparison to those with ASI and control. There is no significant difference in glenoid version among patients with ASI when compared with control. Level of Evidence: Level III, retrospective comparative study.

Spatial spillover impact of determinants on child mortality in Pakistan: evidence from Spatial Durbin Model.

BACKGROUND: Child mortality is a major challenge to public health in Pakistan and other developing countries. Reduction of the child mortality rate would improve public health and enhance human well-being and prosperity. This study recognizes the spatial clusters of child mortality across districts of Pakistan and identifies the direct and spatial spillover effects of determinants on the Child Mortality Rate (CMR). METHOD: Data of the multiple indicators cluster survey (MICS) conducted by the United Nations International Children's Emergency Fund (UNICEF) was used to study the CMR. We used spatial univariate autocorrelation to test the spatial dependence between contiguous districts concerning CMR. We also applied the Spatial Durbin Model (SDM) to measure the spatial spillover effects of factors on CMR. RESULTS: The study results showed 31% significant spatial association across the districts and identified a cluster of hot spots characterized by the high-high CMR in the districts of Punjab province. The empirical analysis of the SDM confirmed that the direct and spatial spillover effect of the poorest wealth quintile and MPI vulnerability on CMR is positive whereas access to postnatal care to the newly born child and improved drinking water has negatively (directly and indirectly) determined the CMR in Pakistan. CONCLUSION: The instant results concluded that spatial dependence and significant spatial spillover effects concerning CMR exist across districts. Prioritization of the hot spot districts characterized by higher CMR can significantly reduce the CMR with improvement in financial statuses of households from the poorest quintile and MPI vulnerability as well as improvement in accessibility to postnatal care services and safe drinking water.

Thermal and physical impact of viscoplastic nanoparticles in a complex divergent channel due to peristalsis phenomenon: Heat generation and multiple slip effects.

In the advance studies, researchers have performed productive research contributions in the field of nanofluid mechanics under various biological assumptions. These contributions are fruitful to understand the applications of nanofluids in the various fields such as hybrid-powered engine, heart-diagnose, to prevent numerous diseases, heat exchanger, pharmaceutical processes, etc. The current analysis explores the combined effects of heat generation and chemical reaction on the peristaltic flow of viscoplastic nanofluid through a non-uniform (divergent) channel. The physical effects of second-order velocity slip, thermal slip and mass slip parameters on the rheological characteristics are also considered. To describe non-Newtonian effects, the Casson fluid is deployed. The greater wavelength assumption and low Reynolds number theory are used to attain the rheological equations. Numerical solutions of these governing equations associated with suitable boundary conditions are obtained via Mathematica symbolic software. The velocity magnitude of Casson fluid is higher than associated with Newtonian fluid. Radiation parameter has a vigorous impact in the reduction (enhancement) of temperature (mass concentration) profile. The porous parameter has a remarkable impact in reduction of temperature and velocity profile. Thermal enhancement is perceived by intensifying the chemical reaction parameter, and opposite inclination is noticed in mass concentration. Temperature has been demonstrated to be increased by increasing the Darcy number. The magnitudes of both axial velocity and temperature distribution are smaller in the presence of second-order velocity slip parameters effect as compared with no-slip condition. The magnitudes of axial velocity and mass (or, nanoparticle) concentration are augmented by accumulating the Prandtl number. A rise in Brownian parameter is noticed to depress the mass concentration. The present study has been used in bio-mechanical processes, nanomaterial devices, heat transfer enhancement, radiators, and electronics cooling systems.

Entropy optimized flow of Sutterby nanomaterial subject to porous medium: Buongiorno nanofluid model.

Owing to enhanced thermal impact of nanomaterials, different applications are suggested in engineering and industrial systems like heat transfer devices, energy generation, extrusion processes, engine cooling, thermal systems, heat exchanger, chemical processes, manufacturing systems, hybrid-powered plants etc. The current communication concerns the optimized flow of Sutterby nanofluid due to stretched surface in view of different thermal sources. The investigation is supported with the applications of external heat source, magnetic force and radiative phenomenon. The irreversibility investigation is deliberated with implementation of thermodynamics second law. The thermophoresis and random movement characteristics are also studied. Additionally, first order binary reaction is also examined. The nonlinear system of the governing problem is obtained which are numerically computed by s method. The physical aspects of prominent flow parameters are attributed graphically. Further, the analysis for entropy generation and Bejan number is focused. It is observed that the velocity profile increases due to Reynolds number and Deborah number. Larger Schmidt number reduces the concentration distribution. Further, the entropy generation is improved against Reynolds number and Brinkman parameter.

Autologous Skin Grafts, versus Tissue-engineered Skin Constructs: A Systematic Review and Meta-analysis.

For over 100 years, autologous skin grafts have remained the gold standard for the reconstruction of wounds but are limited in availability. Acellular tissue-engineered skin constructs (acellular TCs) and cellular tissue-engineered skin constructs (cellular TCs) may address these limitations. This systematic review and meta-analysis compare outcomes between them. Methods: A systematic review was conducted using PRISMA guidelines, querying MEDLINE, Embase, Web of Science, and Cochrane to assess graft incorporation, failure, and wound healing. Case reports/series, reviews, in vitro/in vivo work, non-English articles or articles without full text were excluded. Results: Sixty-six articles encompassing 4076 patients were included. No significant differences were found between graft failure rates (P = 0.07) and mean difference of percent reepithelialization (p = 0.92) when split-thickness skin grafts were applied alone versus co-grafted with acellular TCs. Similar mean Vancouver Scar Scale was found for these two groups (p = 0.09). Twenty-one studies used at least one cellular TC. Weighted averages from pooled results did not reveal statistically significant differences in mean reepithelialization or failure rates for epidermal cellular TCs compared with split-thickness skin grafts (p = 0.55). Conclusions: This systematic review is the first to illustrate comparable functional and wound healing outcomes between split-thickness skin grafts alone and those co-grafted with acellular TCs. The use of cellular TCs seems promising from preliminary findings. However, these results are limited in clinical applicability due to the heterogeneity of study data, and further level 1 evidence is required to determine the safety and efficacy of these constructs.

Thermal inspection for viscous dissipation slip flow of hybrid nanofluid (TiO2-Al2O3/C2H6O2) using cylinder, platelet and blade shape features.

Hybrid nanofluid are the modified class of nanofluids with extra high thermal performances and present different applications in automotive cooling, heat transfer devices, solar collectors, engine applications, fusion processes, machine cutting, chemical processes etc. This thermal research explores the heat transfer assessment due to hybrid nanofluid with of different shape features. The thermal inspections regarding the hybrid nanofluid model are justified with aluminium oxide and titanium nanoparticles. The base liquid properties are disclosed with ethylene glycol material. The novel impact of current model is the presentation of different shape features namely Platelets, blade and cylinder. Different thermal properties of utilized nanoparticles at various flow constraints are reported. The problem of hybrid nanofluid model is modified in view of slip mechanism, magnetic force and viscous dissipation. The heat transfer observations for decomposition of TiO2-Al2O3/C2H6O2 is assessed by using the convective boundary conditions. The shooting methodology is involved for finding the numerical observations of problem. Graphical impact of thermal parameters is observed for TiO2-Al2O3/C2H6O2 hybrid decomposition. The pronounced observations reveal that thermal rate enhanced for blade shaped titanium oxide-ethylene glycol decomposition. The wall shear force reduces for blade shaped titanium oxide nanoparticles.