Assessment of the Relationship between Dental Anxiety and Oral Health-Related Quality of Life.

BACKGROUND: Dental anxiety and fear are the frequently encountered entities among most of the patients. The present study was conducted to assess the relationship between dental anxiety and quality of life (QoL). MATERIALS AND METHODS: This study comprised of 118 patients. Dental trait anxiety (dental anxiety scale [DAS] and short version of the dental anxiety inventory [S-DAI]), Oral Health Impact Profile (OHIP-14), Decayed, Missing, and Filled Teeth (DMFT) score, and global assessment of functioning were recorded before and after treatment. RESULTS: Out of 118 patients, males were 52 and females were 56. There was a correlation between both oral health ratings and DMFT (P < 0.001). OHIP-14 total score was significantly associated with both dental anxiety measures. DMFT shows significant association with dental anxiety and oral health-related QoL (OH-QoL) (P < 0.05). The mean DAS score before treatment was 17.3 and after treatment was 12.60, S-DAI score was 40.1 and 31.5 before and after treatment respectively, oral health status (patient rating) was 38.4 and 74.20 before and after treatment respectively, oral health status (dentist rating) was 38.7 and 73.1 before and after treatment respectively and aesthetics (dentist rating) was 35.6 and 72.4 before and after treatment respectively. There was improvement of OH-QoL with dental anxiety reduction which was significantly significant (P < 0.05). CONCLUSION: Authors found that there is correlation between dental anxiety and fear with the poor oral health-related oral hygiene.

Use of a Modified Nance Appliance for Esthetic Rehabilitation of a Child Patient with Rare Nonfamilial and Nonsyndromic Oligodontia.

Congenital absence of more than 6 teeth except the third molar is known as oligodontia. It can affect both primary and permanent dentitions. The affected individuals usually demonstrate esthetic, functional, and psychological concerns. The present case report is about a 4-year-old female patient with multiple missing (both primary and permanent) teeth with esthetic and social problems. On extraoral examination, the patient demonstrated upper lip relapse due to missing anterior teeth. On physical examination, no other abnormality was detected in relation to the hair, appendages, or presence of a cleft. On intraoral and radiographic examination, 21 teeth were missing, which included both the primary and the permanent tooth buds. To encourage a positive behavioral change, it was decided to carry out prosthetic intervention using a modified fixed Nance appliance and acrylic teeth. After the replacement of the missing teeth, a marked improvement in the profile and esthetics was seen.

Head and Neck Congenital Anomalies in Neonate Hospitals in Hail, Saudi Arabia.

INTRODUCTION: There is secrecy in the literature published about congenital anomalies of head and neck. Dentists may encounter with many head and neck anomalies during their practice. This study aimed to assess the prevalence of head and neck anomalies among all congenital anomalies and to identify risk factors associated with head and neck anomalies. MATERIALS AND METHODS: A cross-sectional hospital-based study was conducted on neonate data available in the records of neonate hospitals in Hail; records from 1432 to 1438 in Hijri Islamic calendar (equivalent to 2010-2016) were employed. All neonates from birth to 28 days after, who were born or admitted to these hospitals, were included in this study. RESULTS: The prevalence of head and neck anomalies among all congenital anomalies was 5.5%. The highest incidence rate was found in year 1435 (Islamic Hijri Year), in which the incidence rate was 7.1%. Cross tabulation between demographic characteristics and head and neck anomalies revealed that sex of the neonates was significantly associated with head and neck anomalies. The birth weight of the surveyed neonates and consanguinity marriage of the parents had no significant association with head and neck anomalies. CONCLUSION: The occurrence of head and neck anomalies showed a wide variation in different years, and the prevalence among other anomalies is associated significantly with sex of newborn. HOW TO CITE THIS ARTICLE: Assiry AA, Khan SD, Al-Shubrmi HR, et al. Head and Neck Congenital Anomalies in Neonate Hospitals in Hail, Saudi Arabia. Int J Clin Pediatr Dent 2020;13(2):160-162.

KMT2C, a histone methyltransferase, is mutated in a family segregating non-syndromic primary failure of tooth eruption.

Primary failure of tooth eruption (PFE) is a rare odontogenic defect and is characterized by failure of eruption of one or more permanent teeth. The aim of the study is to identify the genetic defect in a family with seven affected individuals segregating autosomal dominant non-syndromic PFE. Whole genome single-nucleotide polymorphism (SNP) genotyping was performed. SNP genotypes were analysed by DominantMapper and multiple shared haplotypes were detected on different chromosomes. Four individuals, including three affected, were exome sequenced. Variants were annotated and data were analysed while considering candidate chromosomal regions. Initial analysis of variants obtained by whole exome sequencing identified damaging variants in C15orf40, EPB41L4A, TMEM232, KMT2C, and FBXW10 genes. Sanger sequencing of all family members confirmed segregation of splice acceptor site variant (c.1013-2 A > G) in the KMT2C gene with the phenotype. KMT2C is considered as a potential candidate gene based on segregation analysis, the absence of variant in the variation databases, the presence of variant in the shared identical by descent (IBD) region and in silico pathogenicity prediction. KMT2C is a histone methyltransferase and recently the role of another member of this family (KMT2D) has been implicated in tooth development. Moreover, protein structures of KMT2C and KMT2D are highly similar. In conclusion, we have identified that the KMT2C gene mutation causes familial non-syndromic PFE. These findings suggest the involvement of KMT2C in the physiological eruption of permanent teeth.