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J Biomech ; 39(14): 2593-602, 2006.
Artículo en Inglés | MEDLINE | ID: mdl-16277987

RESUMEN

Liquid jet injections have been performed on human skin in vivo and silicone rubber using Intraject needle-free injectors. The discharge characteristics of the liquid jet were measured using a custom-built test instrument. The experiments reveal that a high-speed liquid jet penetrates a soft solid by the formation and opening of a planar crack. The fluid stagnation pressure required for skin penetration decreases with increasing diameter of the liquid jet. These findings are consistent with the slow-speed penetration of a soft solid by a sharp-tipped punch. It is demonstrated that the Shergold-Fleck sharp-tipped punch penetration model [Shergold, O.A., Fleck, N.A., 2004. Mechanisms of deep penetration of soft solids. Proc. Roy. Soc. Lond. A 460, 3037-3058.] gives adequate predictions for the pressure required to penetrate a soft solid by a high-speed liquid jet.


Asunto(s)
Sistemas de Liberación de Medicamentos/métodos , Piel/fisiopatología , Heridas Penetrantes/fisiopatología , Fenómenos Biomecánicos , Sistemas de Liberación de Medicamentos/instrumentación , Humanos , Inyecciones a Chorro/instrumentación , Inyecciones a Chorro/métodos , Modelos Teóricos , Presión , Punciones , Resistencia al Corte , Elastómeros de Silicona/química
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