RESUMEN
A new model of cirrhosis of the liver was created in experiment on 30 rats. Over 3 weeks, experimental animals in addition to the standard diet daily intragastrically received corn oil in combination with intragastric administration of acetaminophen in a dose of 500 mg/day. High-fat load in combination with acetaminophen over 3 weeks led to the development of focal biliary cirrhosis.
Asunto(s)
Cirrosis Hepática/patología , Modelos Teóricos , Acetaminofén/toxicidad , Animales , Aceite de Maíz , Grasas de la Dieta , Femenino , Hígado/efectos de los fármacos , Hígado/patología , Cirrosis Hepática/inducido químicamente , RatasRESUMEN
The study examined implication of tributyrin, a metabolic precursor in small intestinal microflora, in stimulation of electrical activity of duodenum and jejunum. Enteral administration of tributyrin enhanced electrical activity of both examined structures in small intestine with elimination of the rest periods. The stimulatory effect was manifested in a prolongation of the periods of irregular activity. The up-regulating effects of tributyrin on electrical activity in upper segments of small intestine are mediated via the cholecystokinin receptors being also associated with activation of cholinergic and blockade of nitrinergic signal transduction pathways.
Asunto(s)
Duodeno/efectos de los fármacos , Fármacos Gastrointestinales/farmacología , Yeyuno/efectos de los fármacos , Complejo Mioeléctrico Migratorio/efectos de los fármacos , Triglicéridos/farmacología , Animales , Animales no Consanguíneos , Atropina/farmacología , Duodeno/metabolismo , Electrodos Implantados , Electromiografía , Nutrición Enteral , Microbioma Gastrointestinal/fisiología , Expresión Génica , Yeyuno/metabolismo , Complejo Mioeléctrico Migratorio/fisiología , Nitroglicerina/farmacología , Octreótido/farmacología , Ratas , Receptores de Colecistoquinina/agonistas , Receptores de Colecistoquinina/genética , Receptores de Colecistoquinina/metabolismoRESUMEN
Studying the mechanisms of the small intestine motor function disorders during endotoxemia and searching ways to mitigate them remain relevant. The article discusses the role of inflammatory mediators, in particular nitric oxide as a key factor in the generation of inflammatory response and brake the main neurotransmitter in the gut in the pathogenesis of the small intestine motor disorders during endotoxemia. Also discusses anti-inflammatory cholinergic path, which is realized with the participation of the autonomic nervous system. Possible mechanisms by which tributyrinte as a component of nutritional support creates a multiplier effect in arresting the inflammatory response and normalization of intestinal motility are suggested.
Asunto(s)
Antiinflamatorios/uso terapéutico , Endotoxemia/tratamiento farmacológico , Nutrición Enteral/métodos , Motilidad Gastrointestinal/efectos de los fármacos , Intestino Delgado/fisiopatología , Triglicéridos/uso terapéutico , Antiinflamatorios/administración & dosificación , Endotoxemia/inmunología , Endotoxemia/fisiopatología , Motilidad Gastrointestinal/inmunología , Humanos , Intestino Delgado/efectos de los fármacos , Intestino Delgado/inmunología , Triglicéridos/administración & dosificaciónRESUMEN
The effect of enteral administration of tributyrin on electrical activity in the upper segments of the small intestine was examined in rats on the model of postoperative ileus. This postoperative state is characterized with pronounced and long-term disturbances in generation of migrating myoelectric complex of the small intestine. The enteral administration of tributyrin in the early postoperative period aimed to suppress the non-adrenergic non-cholinergic influences and activation of the cholinergic anti-inflammatory pathways is an effective procedure to normalize the migrating myoelectric complex and therefore the coordinated propulsive peristalsis in the small intestine.
