Smart filtering facepiece respirator with self-adaptive fit and wireless humidity monitoring.

The widespread emergence of airborne diseases has transformed our lifestyle, and respirators have become an essential part of daily life. Nevertheless, finding respirators that fit well can be challenging due to the variety of human facial sizes and shapes, potentially compromising protection. In addition, the current respirators do not inform the user of the air quality in case of continuous long-term use. Here, we introduce a smart filtering facepiece respirator incorporating a humidity sensor and pressure sensory feedback for self-fit adjusting and maintaining an adequate fit. The humidity detection sensor uses laser-induced graphene, and the pressure sensor array based on the dielectric elastomeric sponge monitors the respirator contact on the user's face, providing real-time closed-loop feedback and the wearer's fitting status. Those membrane sensors show outstanding performance, such as a low humidity hysteresis of 0.131 % and a precise pressure detection limit of 0.23 ± 0.02 kPa. As a result of the self-fit adjusting mode, the overall fit factor is increased by 10 % on average compared to the commercial respirator. This significant improvement in fit factor, coupled with the innovative design, has the potential to develop next-generation facepiece respirators as essential personal protective equipment.

Human Circulatory/Respiratory-Inspired Comprehensive Air Purification System.

The circulatory and respiratory systems in humans are marvels of biological engineering that exhibit competence in maintaining homeostasis. These systems not only shield the organism from external contaminants but also orchestrate the vital gases via the bloodstream to sustain cellular respiration and metabolic processes across diverse tissues. It is noticed that spaces inhabited encounter challenges akin to those of the human body: protecting the indoor air from external pollutants while removing anthropogenic byproducts like carbon dioxide (CO2), particulate matters (PM), and volatile organic compounds (VOCs) tooutside. A biomimetic approach, composed of a microbubble-based gas exchanger and circulating liquid inspired by alveoli, capillary beds, and bloodstream of the human circulatory/respiratory system, offer an innovative solution for comprehensive air purification of hermetic spaces. Circulatory/respiratory-inspired air purification system (CAPS) ensure both continuous removal of PM and exchange of gas species between indoor and outdoor environments to maintain homeostasis. The effectiveness of this system is also supported by animal behavior experiments with and without CAPS, showing an effect of reducing CO2 concentration by 30% and increasing mice locomotor activity by 53%. CAPS is expected to evolve into robust and comprehensive air purification schemes through the networked integration of plural internal and external environments.

MXene-Enhanced Ionovoltaic Effect by Evaporation and Water Infiltration in Semiconductor Nanochannels.

In recent years, substantial attention has been directed toward energy-harvesting systems that exploit sunlight energy and water resources. Intensive research efforts are underway to develop energy generation methodologies through interactions with water using various materials. In the present investigation, we synthesized sodium vanadium oxide (SVO) nanorods with n-type semiconductor characteristics. These nanorods facilitate the initiation of capillary phenomena within nanochannels, thereby enhancing the interfacial area between nanomaterials and ions. The open-circuit voltage (VOC) was 0.8 V, and the short-circuit current (ISC) was 30 µA, which were continuously monitored at room temperature using a 0.1 M saltwater solution. Additionally, we achieved enhanced energy generation by efficiently converting light energy into thermal energy using MXene, a 2D material. This was accomplished through the photothermal effect, leveraging the inherent semiconductor characteristics. Under light exposure, the system exhibited improved performance attributed to heightened ion diffusion and increased conductivity. This phenomenon was a result of the concerted synergy between ions and electrons facilitated by a semiconductor nanofluidic channel. Ultimately, we demonstrated an application to showcase real-world viability. In this scenario, electricity was harvested through a smart buoy floating on the water, and, based on this, data from the surrounding environment was sensed and wirelessly transmitted.

Rapid prototyping and facile customization of conductive hydrogel bioelectronics based on all laser process.

Proper customization in size and shape is essential in implantable bioelectronics for stable bio-signal recording. Over the past decades, many researchers have heavily relied on conventional photolithography processes to fabricate implantable bioelectronics. Therefore, they could not avoid the critical limitation of high cost and complex processing steps to optimize bioelectronic devices for target organs with various sizes and shapes. Here, we propose rapid prototyping using all laser processes to fabricate customized bioelectronics. PEDOT:PSS is selectively irradiated by an ultraviolet (UV) pulse laser to form wet-stable conductive hydrogels that can softly interact with biological tissues (50 µm line width). The encapsulation layer is selectively patterned using the same laser source by UV-curing polymer networks (110 µm line width). For high stretchability (over 100%), mesh structures are made by the selective laser cutting process. Our rapid prototyping strategy minimizes the use of high-cost equipment, using only a single UV laser source to process the electrodes, encapsulation, and substrates that constitute bioelectronics without a photomask, enabling the prototyping stretchable microelectrode array with an area of 1 cm2 less than 10 min. We fabricated an optimized stretchable microelectrode array with low impedances (∼1.1 kΩ at 1 kHz) that can effectively record rat's cardiac signals with various health states.

ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy.

Parkinson's disease (PD), characterized by dopaminergic neuron degeneration in the substantia nigra, is caused by various genetic and environmental factors. Current treatment methods are medication and surgery; however, a primary therapy has not yet been proposed. In this study, we aimed to develop a new treatment for PD that induces direct reprogramming of dopaminergic neurons (iDAN). Achaete-scute family bHLH transcription factor 1 (ASCL1) is a primary factor that initiates and regulates central nervous system development and induces neurogenesis. In addition, it interacts with BRN2 and MYT1L, which are crucial transcription factors for the direct conversion of fibroblasts into neurons. Overexpression of ASCL1 along with the transcription factors NURR1 and LMX1A can directly reprogram iDANs. Using a retrovirus, GFP-tagged ASCL1 was overexpressed in astrocytes. One week of culture in iDAN convertsion medium reprogrammed the astrocytes into iDANs. After 7 days of differentiation, TH+/TUJ1+ cells emerged. After 2 weeks, the number of mature TH+/TUJ1+ dopaminergic neurons increased. Only ventral midbrain (VM) astrocytes exhibited these results, not cortical astrocytes. Thus, VM astrocytes can undergo direct iDAN reprogramming with ASCL1 alone, in the absence of transcription factors that stimulate dopaminergic neurons development. [BMB Reports 2024; 57(8): 363-368].

Untethered soft actuators for soft standalone robotics.

Soft actuators produce the mechanical force needed for the functional movements of soft robots, but they suffer from critical drawbacks since previously reported soft actuators often rely on electrical wires or pneumatic tubes for the power supply, which would limit the potential usage of soft robots in various practical applications. In this article, we review the new types of untethered soft actuators that represent breakthroughs and discuss the future perspective of soft actuators. We discuss the functional materials and innovative strategies that gave rise to untethered soft actuators and deliver our perspective on challenges and opportunities for future-generation soft actuators.

Phase patterning of liquid crystal elastomers by laser-induced dynamic crosslinking.

Liquid crystal elastomers hold promise in various fields due to their reversible transition of mechanical and optical properties across distinct phases. However, the lack of local phase patterning techniques and irreversible phase programming has hindered their broad implementation. Here we introduce laser-induced dynamic crosslinking, which leverages the precision and control offered by laser technology to achieve high-resolution multilevel patterning and transmittance modulation. Incorporation of allyl sulfide groups enables adaptive liquid crystal elastomers that can be reconfigured into desired phases or complex patterns. Laser-induced dynamic crosslinking is compatible with existing processing methods and allows the generation of thermo- and strain-responsive patterns that include isotropic, polydomain and monodomain phases within a single liquid crystal elastomer film. We show temporary information encryption at body temperature, expanding the functionality of liquid crystal elastomer devices in wearable applications.

A Gradient Stiffness-Programmed Circuit Board by Spatially Controlled Phase-Transition of Supercooled Hydrogel for Stretchable Electronics Integration.

Due to emerging demands in soft electronics, there is an increasing need for material architectures that support robust interfacing between soft substrates, stretchable electrical interconnects, and embedded rigid microelectronics chips. Though researchers have adopted rigid-island structures to solve the issue, this approach merely shifts stress concentrations from chip-conductor interfaces to rigid-island-soft region interfaces in the substrate. Here, a gradient stiffness-programmed circuit board (GS-PCB) that possesses high stretchability and stability with surface mounted chips is introduced. The board comprises a stiffness-programmed hydrogel substrate and a laser-patterned liquid metal conductor. The hydrogel simultaneously obtains a large stiffness disparity and robust interfaces between rigid-islands and soft regions. These seemingly contradictory conditions are accomplished by adopting a gradient stiffness structure at the interfaces, enabled by combining polymers with different interaction energies and a supercooled sodium acetate solution. By integrating the gel with laser-patterned liquid metal with exceptional properties, GS-PCB exhibits higher electromechanical stability than other rigid-island research. To highlight the practicality of this approach, a finger-sensor device that successfully distinguishes objects by direct physical contact is fabricated, demonstrating its stability under various mechanical disturbances.

Machine-learned wearable sensors for real-time hand-motion recognition: toward practical applications.

Soft electromechanical sensors have led to a new paradigm of electronic devices for novel motion-based wearable applications in our daily lives. However, the vast amount of random and unidentified signals generated by complex body motions has hindered the precise recognition and practical application of this technology. Recent advancements in artificial-intelligence technology have enabled significant strides in extracting features from massive and intricate data sets, thereby presenting a breakthrough in utilizing wearable sensors for practical applications. Beyond traditional machine-learning techniques for classifying simple gestures, advanced machine-learning algorithms have been developed to handle more complex and nuanced motion-based tasks with restricted training data sets. Machine-learning techniques have improved the ability to perceive, and thus machine-learned wearable soft sensors have enabled accurate and rapid human-gesture recognition, providing real-time feedback to users. This forms a crucial component of future wearable electronics, contributing to a robust human-machine interface. In this review, we provide a comprehensive summary covering materials, structures and machine-learning algorithms for hand-gesture recognition and possible practical applications through machine-learned wearable electromechanical sensors.

Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells.

UPF1 and LIN28A are RNA-binding proteins involved in post-transcriptional regulation and stem cell differentiation. Most studies on UPF1 and LIN28A have focused on the molecular mechanisms of differentiated cells and stem cell differentiation, respectively. We reveal that LIN28A directly interacts with UPF1 before UPF1-UPF2 complexing, thereby reducing UPF1 phosphorylation and inhibiting nonsense-mediated mRNA decay (NMD). We identify the interacting domains of UPF1 and LIN28A; moreover, we develop a peptide that impairs UPF1-LIN28A interaction and augments NMD efficiency. Transcriptome analysis of human pluripotent stem cells (hPSCs) confirms that the levels of NMD targets are significantly regulated by both UPF1 and LIN28A. Inhibiting the UPF1-LIN28A interaction using a CPP-conjugated peptide promotes spontaneous differentiation by repressing the pluripotency of hPSCs during proliferation. Furthermore, the UPF1-LIN28A interaction specifically regulates transcripts involved in ectodermal differentiation. Our study reveals that transcriptome regulation via the UPF1-LIN28A interaction in hPSCs determines cell fate.

Strain-Insensitive Outdoor Wearable Electronics by Thermally Robust Nanofibrous Radiative Cooler.

Stable outdoor wearable electronics are gaining attention due to challenges in sustaining consistent device performance outdoors, where sunlight exposure and user movement can disrupt operations. Currently, researchers have focused on integrating radiative coolers into wearable devices for outdoor thermal management. However, these approaches often rely on heat-vulnerable thermoplastic polymers for radiative coolers and strain-susceptible conductors that are unsuitable for wearable electronics. Here, we introduce mechanically, electrically, and thermally stable wearable electronics even when they are stretched under sunlight to address these challenges. This achievement is realized by integrating a polydimethylsiloxane nanofibrous cooler and liquid metal conductors for a fully stable wearable device. The thermally robust architecture of nanofibers, based on their inherent properties as thermoset polymers, exhibits excellent cooling performance through high solar reflection and thermal emission. Additionally, laser-patterned conductors possess ideal properties for wearable electronics, including strain-insensitivity, nonsmearing behavior, and negligible contact resistance. As proof, we developed wearable electronics integrated with thermally and electromechanically stable components that accurately detect physiological signals in harsh environments, including light exposure, while stretched up to 30%. This work highlights the potential for the development of everyday wearable electronics capable of reliable operation under challenging external conditions, including user-activity-induced stress and sunlight exposure.

High Efficiency Breathable Thermoelectric Skin Using Multimode Radiative Cooling/Solar Heating Assisted Large Thermal Gradient.

This study proposes a Janus structure-based stretchable and breathable thermoelectric skin with radiative cooling (RC) and solar heating (SH) functionalities for sustainable energy harvesting. The challenge of the wearable thermoelectric generator arises from the small temperature difference. Thus, this dual-sided structure maximizes the thermal gradient between the body and the surrounding environment, unlike the previous works that rather concentrate on the efficiency of the thermoelectric generator itself. The Janus structure allows the device to switch to the other mode, optimizing electricity generation from a given weather condition. For these functionalities, for the first time, boron nitride-polydimethylsiloxane (BP) and graphene nanoplatelet-polydimethylsiloxane (GP) nanofiber (NF) are developed as substrates. The BP NF generates the RC capability of ΔTcooling  = 4 °C, and the high solar absorbance of the GP NF enables it to be photothermally heated. The flip-overable thermoelectric skin (FoTES) achieves a maximum power output (Pmax ) of 5.73 µW cm-2 in RC mode, surpassing SH mode by 5.55 µW cm-2 in the morning. In the afternoon, it generates a Pmax of 18.59 µW cm-2 in SH mode, outperforming RC mode by 15.56 µW cm-2 . This work contributes to the advancement of wearable electronics, offering a sustainable power source in a wearable form.

Tunable Radiative Cooling by Mechanochromic Electrospun Micro-Nanofiber Matrix.

Radiative thermoregulation has been regarded as an energy-efficient method for thermal management. In this study, the development of a mechanoresponsive polydimethylsiloxane (PDMS) micro-nanofiber matrix capable of both sub-ambient radiative cooling and solar heating is presented, achieved through a core-shell electrospinning technique. The electrospun PDMS micro-nanofibers, with diameters comparable to the solar wavelengths, exhibit excellent solar reflectivity (≈93%) while preserving its pristine high infrared (IR) emissivity. As a result, the electrospun PDMS radiative cooler (EPRC) successfully demonstrated sub-ambient radiative cooling performance (≈3.8°C) during the daytime. Furthermore, the exceptional resilient property of PDMS facilitated the reversible alteration of the structural morphology created by the fiber-based matrix under mechanical force, resulting in the modulation of solar reflectivity (≈80%). The precise modulation of solar reflectivity enabled reversibly switchable multi-step radiative thermoregulation, offering enhanced flexibility in addressing varying thermal environments even in maintaining the desired temperature. The findings of this work offer a promising approach toward dynamic radiative thermoregulation, which holds significant potential for addressing global climate change concerns and energy shortage.

Photothermal Lithography for Realizing a Stretchable Multilayer Electronic Circuit Using a Laser.

Photolithography is a well-established fabrication method for realizing multilayer electronic circuits. However, it is challenging to adopt photolithography to fabricate intrinsically stretchable multilayer electronic circuits fully composed of an elastomeric matrix, due to the opacity of thick stretchable nanocomposite conductors. Here, we present photothermal lithography that can pattern elastomeric conductors and via holes using pulsed lasers. The photothermal-patterned stretchable nanocomposite conductor exhibits 3 times higher conductivity (5940 S cm-1) and 5 orders of magnitude lower resistance change (R/R0 = 40) under a 30% strained 5000th cyclic stretch, compared to those of a screen-printed conductor, based on the percolation network formed by spatial heating of the laser. In addition, a 50 µm sized stretchable via holes can be patterned on the passivation without material ablation and electrical degradation of the bottom conductor. By repeatedly patterning the conductor and via holes, highly conductive and durable multilayer circuits can be stacked with layer-by-layer material integration. Finally, a stretchable wireless pressure sensor and passive matrix LED array are demonstrated, thus showing the potential for a stretchable multilayer electronic circuit with durability, high density, and multifunctionality.

Laser-Based Selective Material Processing for Next-Generation Additive Manufacturing.

The connection between laser-based material processing and additive manufacturing is quite deeply rooted. In fact, the spark that started the field of additive manufacturing is the idea that two intersecting laser beams can selectively solidify a vat of resin. Ever since, laser has been accompanying the field of additive manufacturing, with its repertoire expanded from processing only photopolymer resin to virtually any material, allowing liberating customizability. As a result, additive manufacturing is expected to take an even more prominent role in the global supply chain in years to come. Herein, an overview of laser-based selective material processing is presented from various aspects: the physics of laser-material interactions, the materials currently used in additive manufacturing processes, the system configurations that enable laser-based additive manufacturing, and various functional applications of next-generation additive manufacturing. Additionally, current challenges and prospects of laser-based additive manufacturing are discussed.

Hierarchical 3D Percolation Network of Ag-Au Core-Shell Nanowire-Hydrogel Composite for Efficient Biohybride Electrodes.

Metal nanomaterials are highly valued for their enhanced surface area and electrochemical properties, which are crucial for energy devices and bioelectronics. However, their practical applications are often limited by challenges, such as scalability and dimensional constraints. In this study, we developed a synthesis method for highly porous Ag-Au core-shell nanowire foam (AACNF) using a one-pot process based on a simultaneous nanowelding synthesis method. The unique characteristics of AACNF as metal-based electrodes show the lowest density among metal-based electrodes while demonstrating high electrical conductivity (99.33-753.04 S/m) and mechanical stability. The AACNF's excellent mass transport properties enable multiscale hierarchical incorporation with functional materials including polymeric precursors and living cells. The enhanced mechanical stability at the nanowelded junctions allows AACNF-hydrogel composites to exhibit large stretching (∼700%) and 10,000 times higher electrical conductivity than hydrogel-nanowire composites without the junction. Large particles in the 1-10 µm scale, including fibroblast cells and exoelectrogenic microbes, are also successfully incorporated with AACNF. AACNF-based microbial fuel cells show high power density (∼330.1 W/m3) within the optimal density range. AACNF's distinctive ability to form a hierarchical structure with substances in various scales showcases its potential for advanced energy devices and biohybrid electrodes in the future.

Photothermally Activated Artificial Neuromorphic Synapses.

Biological nervous systems rely on the coordination of billions of neurons with complex, dynamic connectivity to enable the ability to process information and form memories. In turn, artificial intelligence and neuromorphic computing platforms have sought to mimic biological cognition through software-based neural networks and hardware demonstrations utilizing memristive circuitry with fixed dynamics. To incorporate the advantages of tunable dynamic software implementations of neural networks into hardware, we develop a proof-of-concept artificial synapse with adaptable resistivity. This synapse leverages the photothermally induced local phase transition of VO2 thin films by temporally modulated laser pulses. Such a process quickly modifies the conductivity of the film site-selectively by a factor of 500 to "activate" these neurons and store "memory" by applying varying bias voltages to induce self-sustained Joule heating between electrodes after activation with a laser. These synapses are demonstrated to undergo a complete heating and cooling cycle in less than 120 ns.

Transparent Electronics for Wearable Electronics Application.

Recent advancements in wearable electronics offer seamless integration with the human body for extracting various biophysical and biochemical information for real-time health monitoring, clinical diagnostics, and augmented reality. Enormous efforts have been dedicated to imparting stretchability/flexibility and softness to electronic devices through materials science and structural modifications that enable stable and comfortable integration of these devices with the curvilinear and soft human body. However, the optical properties of these devices are still in the early stages of consideration. By incorporating transparency, visual information from interfacing biological systems can be preserved and utilized for comprehensive clinical diagnosis with image analysis techniques. Additionally, transparency provides optical imperceptibility, alleviating reluctance to wear the device on exposed skin. This review discusses the recent advancement of transparent wearable electronics in a comprehensive way that includes materials, processing, devices, and applications. Materials for transparent wearable electronics are discussed regarding their characteristics, synthesis, and engineering strategies for property enhancements. We also examine bridging techniques for stable integration with the soft human body. Building blocks for wearable electronic systems, including sensors, energy devices, actuators, and displays, are discussed with their mechanisms and performances. Lastly, we summarize the potential applications and conclude with the remaining challenges and prospects.

Photonic structures in radiative cooling.

Radiative cooling is a passive cooling technology without any energy consumption, compared to conventional cooling technologies that require power sources and dump waste heat into the surroundings. For decades, many radiative cooling studies have been introduced but its applications are mostly restricted to nighttime use only. Recently, the emergence of photonic technologies to achieves daytime radiative cooling overcome the performance limitations. For example, broadband and selective emissions in mid-IR and high reflectance in the solar spectral range have already been demonstrated. This review article discusses the fundamentals of thermodynamic heat transfer that motivates radiative cooling. Several photonic structures such as multilayer, periodical, random; derived from nature, and associated design procedures were thoroughly discussed. Photonic integration with new functionality significantly enhances the efficiency of radiative cooling technologies such as colored, transparent, and switchable radiative cooling applications has been developed. The commercial applications such as reducing cooling loads in vehicles, increasing the power generation of solar cells, generating electricity, saving water, and personal thermal regulation are also summarized. Lastly, perspectives on radiative cooling and emerging issues with potential solution strategies are discussed.

Advancement in COVID-19 detection using nanomaterial-based biosensors.

Coronavirus disease 2019 (COVID-19) pandemic has exemplified how viral growth and transmission are a significant threat to global biosecurity. The early detection and treatment of viral infections is the top priority to prevent fresh waves and control the pandemic. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified through several conventional molecular methodologies that are time-consuming and require high-skill labor, apparatus, and biochemical reagents but have a low detection accuracy. These bottlenecks hamper conventional methods from resolving the COVID-19 emergency. However, interdisciplinary advances in nanomaterials and biotechnology, such as nanomaterials-based biosensors, have opened new avenues for rapid and ultrasensitive detection of pathogens in the field of healthcare. Many updated nanomaterials-based biosensors, namely electrochemical, field-effect transistor, plasmonic, and colorimetric biosensors, employ nucleic acid and antigen-antibody interactions for SARS-CoV-2 detection in a highly efficient, reliable, sensitive, and rapid manner. This systematic review summarizes the mechanisms and characteristics of nanomaterials-based biosensors for SARS-CoV-2 detection. Moreover, continuing challenges and emerging trends in biosensor development are also discussed.