RESUMEN
The correlation between the structures and conformations of short peptides KE, EW, AEDG and other, their influence on the dynamic properties of water and dose/biologic effect dependencies in a wide range of concentrations were regarded. Their effects on the dynamic properties of water were studied by temperature dependencies (5-45 degrees C) of infrared spectra of the solutions in the near (5180 cm-1) and far (200 cm-1). In vitro biotesting included the determination of the proliferative activity of thymocytes, a bimodal curve with the second maximum were detected at super-low doses (10(-17)-10(-15) mol/l). Authors propose a hypothesis that for superlow concentrations the formation and distance transmission of a signal from ligand to a target cell without the formation of any ligand-receptor complex take place. An active role in this model belongs to water medium acting according to the solution mechanism.
Asunto(s)
Relación Dosis-Respuesta a Droga , Péptidos/farmacología , Agua , Animales , División Celular/efectos de los fármacos , Células Cultivadas , Concanavalina A/farmacología , Medios de Cultivo , Dipéptidos/farmacología , Masculino , Ratones , Ratones Endogámicos , Modelos Moleculares , Modelos Teóricos , Oligopéptidos/farmacología , Péptidos/administración & dosificación , Péptidos/química , Conformación Proteica , Soluciones , Espectrofotometría Infrarroja , Temperatura , Timo/citología , Timo/efectos de los fármacos , Timo/metabolismo , Agua/química , Agua/metabolismoRESUMEN
Possible involvement of aqueous medium in distant signal transmission to target cells through solitons without formation of the ligand-receptor complexes is discussed. Temperature dependence of IR spectra for dipeptide and amino acid solutions in the far and near IR regions are presented, which prove principal possibility of such processes.
Asunto(s)
Péptidos/química , Sitios de Unión , Fenómenos Biofísicos , Biofisica , Ligandos , Modelos Químicos , Estructura Terciaria de Proteína , Espectrofotometría Infrarroja , Temperatura , Agua/químicaRESUMEN
The effect of amino acids and low-molecular-weight peptides on the dynamics of water was studied. Water medium together with molecules of dipeptides and amino acids dissolved in it is considered as a complex of interacting anharmonic oscillators. It was shown that the temperature behaviour of this system is determined by nonlinear resonances, which give rise to both the phenomenon of self-synchronization in the whole system or its part and to the phenomena of phase instability and coherence decay, depending on the store of oscillatory energy. Dissolved molecules are also involved in these oscillations, and if the frequencies and amplitudes of their oscillations are within the range in which nonlinear resonance occurs, they can affect the movement of the whole system.
