RESUMEN
Data in the literature on the prevalence of hereditary deficiency of the natural coagulation inhibitors are conflicting. We conducted a prospective study on 680 consecutive patients with a history of venous thrombosis to determine the prevalence of hereditary deficiency of antithrombin III (AT III), protein C(PC) and protein S(PS) and to establish selection criteria for rational patient screening. The mean age of the patients at investigation was 44.3 +/- 15.4 years, while that at the first thrombotic event was 38.5 +/- 14.8 years. The total prevalence of inhibitor deficiency states was 48/680 (7.1%). 19/680 patients (2.8%) had AT III-deficiency, 17 (2.5%) PC-deficiency, nine (1.3%) PS-deficiency and three (0.4%) a combined deficiency. In 37/48 deficient patients family studies were performed and the hereditary nature was established in 19 cases (2.8% of total patient population, six with AT III-deficiency, eight with PC-deficiency, four with PS-deficiency and one with a combined deficiency). Family studies in these 19 patients revealed 46 additional individual patients with a hereditary deficiency state. A positive family history was found in 15/19 (79%) with a proven hereditary deficiency state, in 153/619 (25%) of non-deficient patients and in 11/29 (38%) of deficient patients without established hereditary nature. The mean age at the first thrombotic event was significantly lower in patients with a hereditary deficiency state (26.8 years) compared with the other two groups (39.0 and 39.7 years, respectively). In all patients with a hereditary deficiency the first thrombotic event occurred before the age of 45 years.(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
Deficiencia de Antitrombina III , Trastornos de la Coagulación Sanguínea/genética , Deficiencia de Proteína C , Deficiencia de Proteína S , Adolescente , Adulto , Anciano , Austria , Trastornos de la Coagulación Sanguínea/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Tromboflebitis/genéticaAsunto(s)
Coagulación Sanguínea/efectos de los fármacos , Cefalosporinas/uso terapéutico , Pruebas de Coagulación Sanguínea , Cefotaxima/uso terapéutico , Ceftriaxona/uso terapéutico , Ensayos Clínicos como Asunto , Humanos , Moxalactam/uso terapéutico , Distribución Aleatoria , Relación Estructura-ActividadRESUMEN
The Poison Control Centre in Vienna registered 4018 inquires regarding possible poisoning in children over a two-year period. The peak incidence occurred in the age group between 2 and 3 years and poisoning chiefly took place in the mornings and in the afternoons, the most frequently ingested substances being household chemicals and drugs. A study in 100 households showed ignorance and carelessness in dealing with chemical substances. An analysis of inquiries concerning medicines revealed the influence of packaging and external characteristics on the frequency of poisoning with these substances. Possibilities which might be of value in the prevention of poisoning in children are discussed.