[The study of HLA-associations of chronic obstructive disease of lungs in conditions of organic-silicon manufacture].

The purpose of study is to examine associations of polymorphic allele genes HLA class II - DRB1, DQA1 and DQB1 and their haplotypic combinations with chronic obstructive disease of lungs in workers of organocilicic manufacture in Chuvash population. The HLA-genotyping was implemented to 50 patients with chronic obstructive disease of lungs and 38 healthy workers of organocilicic manufacture, belonging to Chuvash ethnic population. The genotyping was implemented on three genes HLA: DRB1 (14 alleles), DQA1 (8 alleles) and DQB1 (11 alleles) using multi-primary polymerase chain reaction technique. The typing was implemented using kits manufactured by "DNA-Technology" (Russia). The degree of association ofHLA-alleles and gaplotypes with development of chronic obstructive disease of lungs in conditions of organocilicic manufacture was determined by value of relative risk (rr). The study established negative associations of chronic obstructive disease of lungs with alleles HLA-DRB1*01 (rr=0.021; p<0.001); DQA1*0101 (rr=0.013; p<0.001); DQB1*0501 (rr=0.021; p<0.001) andgaplotypes DRB1*01-DQA1*0101 (rr=0.031; p<0.01); DRB1*07-DQA1*0201 (rr=0.076; p<0.01); Bm1*13-DQA1*0102 (rr=0.11; p<0.05). The HLA-markers of resistance to development of chronic obstructive disease of lungs in conditions of organocilicic manufacture in Chuvash population.

[THE CHARACTERISTICS OF CYTOKINE STATUS UNDER DIFFERENT CLINICAL VARIANTS OF GLOMERULONEPHRITIS].

The article presents results of identification of indicators of cytokine status in 58 patients with glomerulonephritis using solid-phase immunoenzyme analysis. It is established that in patients with glomerulonephritis the level of pro-inflammatory and anti-inflammatory cytokines (IL-lß, IL-2, IL-10 and Ra-IL-1ß) circulating in blood is augmented. The differences are established concerning cytokine status of patients depending on clinical type of disease. The level of production of IL-10, correlating with glomerular, tubular and erythropoietic functions of kidneys significantly effected formation of various clinical types of glomerulonephritis.

[Topographic and quantitative characteristics of adipose tissue in various aborigines of Siberia (women)]. / Topograficheskaia i kolichestvennaia kharakteristika zhirovoi tkani u nekotorykh aborigenov Sibiri (zhenshchiny).

The main task of the investigation is to prove suitability of the scheme suggested for estimation of the dynamics of fat content in the organism, in order to analyse age changeability of topography and amount of the subcutaneous fat in 254 women of various race-geographic groups in Siberia and populations, belonging to different adaptive groups. Representatives of the central-east-european (Russians), north europeoid (Komi), uralian (Manci) and central-asian (Buryats) race groups have been investigated. Age groups of 18-23 and 24-55 years of age have been compared. The first group gives possibilities to estimate the fat content value in the body composition and peculiarities in distribution of the subcutaneous fat in persons at early period of maturation; the second group--to follow age alterations of certain signs. For the representatives of the first group predominance of the subcutaneous fat below the waist is specific. In Russians predominance of the subcutaneous fat in extremities in comparison with the trunk is noted in 47-50%, in Komi, Manci and Buryats--in 12-25%. In the older age group the summational skin-fold thickness of the adipose tissue changes but slightly. For the representatives of all elderly groups increase of the fat content above the waist with predominance in the trunk is specific.