Overview of cloning in lactic acid bacteria: Expression and its application of probiotic potential in inflammatory bowel diseases.

Inflammatory bowel disease (IBD) imposes a significant impact on the quality of life for affected individuals. However, there was a current lack of a systematic summary regarding the latest epidemic trends and the underlying pathogenesis of IBD. This highlights the need for a thorough examination of both the epidemiological aspects of IBD and the specific mechanisms by which lactic acid bacteria (LAB) contribute to mitigating this condition. In developed countries, higher incidences and death rates of IBD have been observed, influenced by a combination of environmental and genetic factors. LAB offer significant advantages and substantial potential for enhancing IBD treatment. LAB's capabilities include the production of bioactive metabolites, regulation of gut immunity, protection of intestinal mechanical barriers, inhibition of oxidative damage, and restoration of imbalanced gut microbiota. The review suggests that screening effective LAB using cell models and metabolites, optimizing LAB intake through dose-effect studies, enhancing utilization through nanoencapsulation and microencapsulation, investigating mechanisms to deepen the understanding of LAB, and refining clinical study designs. These efforts aim to contribute to comprehending the epidemic trend, pathogenesis, and treatment of IBD, ultimately fostering the development of targeted therapeutic products, such as LAB-based interventions.

Clay based heterogeneous catalysts for carbon-nitrogen bond formation: a review.

Clay and modified clay-based catalysts are widely used in organic transformation. Owing to the interlayer ions and good ion exchange capacity of clay, replacement with another ion and incorporation of different nanomaterials can be done. Due to these significant properties of clay, it can be utilized in the synthesis of various organic compounds. Carbon-nitrogen bonded compounds possess diverse applications in different fields. These compounds are prepared using different solid acid heterogeneous catalysts. This review presents a detailed discussion on clay used for the carbon-nitrogen bond formation reaction, such as the Biginelli reaction and A3 and KA2 coupling reactions. Additionally, other C-N bond formation reactions using various clay-based catalysts such as bentonite, montmorillonite, hydrotalcite and halloysite clay with various metals, metal oxides, Kegging type heteropoly acid and various nanomaterial incorporated clay heterogeneous catalysts are discussed.