RESUMEN
BACKGROUND: Accurate volumetric assessment of graft and remnant liver is essential in living donor liver transplantation (LDLT) for optimal clinical outcome in both donors and recipients. Recently, three-dimensional (3D) volumetry is proposed over conventional computed tomography (CT) volumetry to minimise errors. The aim of this study is to assess the correlation of estimated graft volume (EGV) by both the methods with actual graft weight (AGW). METHODS: One hundred fifty-four consecutive donors were enrolled prospectively. Conventional CT volumetry (semiautomatic) and 3D volumetry were performed using Myrian software. Total liver volume (TLV), EGV, and remnant liver volume (RLV) were assessed using both methods and correlated with intraoperatively measured AGW as the reference standard. Error of estimation was calculated accordingly. RESULTS: One hundred eighteen donors underwent right hepatectomy excluding middle hepatic vein (MHV), twenty-nine donors had left hepatectomy including MHV and six donors underwent left lateral sectionectomy. The median EGV on CT and 3D volumetry was 628.5 ml (140-1300) and 634.5 ml (156-1349), respectively. The median AGW was 647 gm (200-1004). Both CT and 3D volumetry showed strong correlation with AGW (correlation coefficients: 0.834 and 0.856, respectively). Linear correlation is as follows: (a) AGW = 99.75 + 0.818 × EGV (CT) and (b) AGW = 96.03 + 0.835 × EGV (3D). The mean percentage error for CT and 3D volumetry was 14.2 ± 12.5% and 12.2 ± 11.8%, respectively. The overall accuracy of estimation of EGV improved using 3D software (P=0.015). For the subgroup of types of graft, the difference did not reach statistical significance (P=0.062, 0.214 and 0.463 for right, left and left lateral grafts, respectively). CONCLUSION: Both conventional CT and 3D volumetric methods strongly correlate with AGW in donors of LDLT, whereas overall accuracy of estimation of graft weight improved marginally by 3D volumetry.
RESUMEN
AIM: The aim of this study was to evaluate the outcomes following upfront pancreaticoduodenectomy (PD) in severely jaundiced (serum bilirubin level ≥15 mg/dl) patients with malignant distal common bile duct (CBD) obstruction. BACKGROUND: Recent studies have failed to show the benefits of preoperative biliary drainage (PBD) before PD. In addition, there is limited data on the impact of upfront PD on perioperative outcomes in severely jaundiced patients. METHODS: We reviewed the prospectively collected data of 177 patients who had undergone PD for the malignant distal CBD obstruction from May 2009 to May 2018. Study subjects were divided into Group A (severely jaundiced patients with upfront PD; n = 20), Group B (patients with serum bilirubin <15 mg/dl and no PBD; n = 88) and Group C (PBD prior to PD; n = 69). Overall morbidity, in-hospital mortality, and postoperative hospital stay were compared. RESULTS: No significant differences were noted between the three groups regarding sex, tumor size and stage, comorbidities, and surgical technique. The intra-operative blood loss was more in severely jaundiced patients as compared to Groups B and C (605 vs. 300 vs. 350 ml, P = 0.0001), but similar operative times, blood transfusions, and rates of post-pancreatectomy leak and hemorrhage. The infective complications were significantly less with upfront surgery. The overall morbidity, in-hospital mortality, and hospital stay were comparable between the three groups. Multiple logistic regression analysis failed to identify both the presence of preoperative jaundice and hyperbilirubinemia ≥15 mg/dl as independent risk factors for post-PD major morbidity. CONCLUSION: Upfront PD can be performed safely in the selected severely jaundiced patients and is associated with significantly lower infective complications.
