Assessment of seasonal water quality and land use land cover change in Subarnarekha watershed of Ranchi stretch in Jharkhand.

In this paper, the assessment of seasonal water quality and land use land cover change in the Subarnarekha watershed in Ranchi stretch was analysed. Agricultural runoff along with climate change adds to the pollution risk to the Subarnarekha River of Ranchi stretch in Jharkhand. Water quality indicators, like acidity alkalinity (ALK), total dissolved solids (TDS), hardness (H), dissolved oxygen (DO), biochemical oxygen demand (BOD), chlorides (CL-), electrical conductivity (EC), salinity (SAL), resistivity (RES) and pH, were assessed as per the standard method. During monsoon season, acidity, alkalinity, hardness, chlorides, salinity, pH and DO decreased, whereas EC, TDS, BOD and resistivity increased in comparison to pre-monsoon season. In post-monsoon, chloride problem was observed very high. Hardness was least in monsoon and maximum in post-monsoon season. EC and BOD increased in monsoon season in comparison to other seasons. Statistical analysis like HCA (hierarchical cluster analysis) and PCA (principal component analysis) also confirmed the problem of TDS, EC, chloride and hardness in the area. WQI (water quality index) analysis showed that the water quality was poor to unsuitable on all the sampling points throughout the study area in all seasons. LULC (land use land cover) and NDWI (normalized difference water index) analysis had also concluded that due to high rate of urbanization, the area has undergone a massive change in terms of forest cover and water bodies. The need for afforestation, forest protection and wetland protection can be clearly seen from the result of this study.

Protective Effects of Rifampicin and Its Analog Rifampicin Quinone in a Mouse Model of Obesity-Induced Type 2 Diabetes.

Advanced glycation end-products (AGEs) form when glucose reacts non-enzymatically with proteins, leading to abnormal protein function, oxidative stress, and inflammation. AGEs are associated with aging and age-related diseases; their formation is aggravated during diabetes. Therefore, drugs preventing AGE formation can potentially treat diabetic complications, positively affecting health. Earlier, we demonstrated that rifampicin and its analogs have potent anti-glycating activities and increase the life span of Caenorhabditis elegans. This study aimed to investigate the effects of rifampicin during hyperglycemia in C. elegans and in a mouse model of obesity-induced type 2 diabetes. The effects of rifampicin were assessed by determining the life span of C. elegans cultured in the presence of glucose and by measuring HbA1c, AGE levels, and glucose excursions in the diabetic mouse model. Our results show that rifampicin protects C. elegans from glucose-induced toxicity and increases life span. In mice, rifampicin reduces HbA1c and AGEs, improves insulin sensitivity, and reduces indications of diabetic nephropathy without inducing hepatotoxicity. Rifampicin quinone, an analog with lower anti-microbial activity, also reduces HbA1c levels, improves glucose homeostasis and insulin sensitivity, and lowers indications of diabetic nephropathy, without adversely affecting the liver of the diabetic mice. Altogether, our results indicate that rifampicin and its analog have protective roles during diabetes without inflicting hepatic damage and may potentially be considered for repositioning to treat hyperglycemia-related complications in patients.

Prediction and monitoring of LULC shift using cellular automata-artificial neural network in Jumar watershed of Ranchi District, Jharkhand.

Jumar watershed of Ranchi district is agrarian in nature. The unplanned and exponentially growing urban sprawl has become one of the probable threats in achieving sustainable development goals (SDG-15). The purpose of this research study is to monitor the urban sprawl in Jumar watershed within three decades i.e. from the year 1990 to 2021. Land use land cover (LULC) change has been monitored using satellite data from LANDSAT (4, 5 and 8). Various indices are calculated like normalised difference vegetation index (NDVI), normalised difference built-up index (NDBI), normalised difference water index (NDWI) and built-up index (BUI) to monitor LULC change in the area. For prediction of urban sprawl, cellular automata and artificial neural network (CA-ANN) with GIS application technique is used. The model is validated by using Kappa coefficient. The prediction results showed increase in built-up area by 8.23 sq. km in the next decade. The built-up and barren land together increase up to 42.85 sq. km by 2030 and 34.61 sq. km in 2021. The NDVI for 3-decade period showed significant decrease in the healthy vegetation and increase in sparse vegetation. The NDBI showed a slight increase in urban area but massive increase in uncultivated and barren land. NDWI showed a decrease in area of the surface water. The LULC studies showed a major shift from healthy vegetation to agriculture and then to barren land. To assess the impact of urbanisation on water quality, water samples are taken seasonally from J1to J11 sampling locations and are analysed as per APHA procedure. The sites are classified as urban, semi urban and rural area as per their location. The water quality index (WQI) varied between 42.14 to 61.42 during pre-monsoon, 62.20 to 68.7995 during monsoon and 43.48 to 60.12 during post-monsoon. The quality of water is found poor in all seasons at all sampling sites. The water is found highly turbid and alkaline throughout the year. Overall, it can be concluded that the water needs to be pre-treated for drinking purposes throughout the year.

In Situ Functionalization of Cellulose with Zinc Pyrithione for Antimicrobial Applications.

Considering the public health demands for stronger and effective personal protective clothing, herein, antimicrobial fabrics using a known bacteriostatic and fungistatic drug zinc pyrithione (ZPT) have been reported. ZPT was synthesized in situ on cellulosic fabric, viscose (VC), using a zinc metal precursor and 2-mercaptopyridine-N-oxide as a ligand (VC-ZPT). For comparison, viscose was also phosphorylated (VP) before in situ functionalization with ZPT (VP-ZPT). Both approaches provided adequate protection from microbes; however, functionalization of cellulose with phosphate (VP) resulted in the formation of a linking group between cellulose and ZPT, which exhibited better uniformity of ZPT over the fabric surface and higher durability to washing. The functionalization was confirmed by inductively coupled plasma mass spectroscopy (ICP-MS), scanning electron microscopy (SEM), and Raman spectroscopy. Further, the bonding of phosphate with ZPT was confirmed by 31P solid-state NMR. The physical properties, such as appearance, bending length, and mechanical strength, of the treated fabrics remained unchanged. The antimicrobial activities of VP-ZPT with VC-ZPT were studied against Escherichia coli, Staphylococcus aureus, and Candida albicans, which were found to be effective until 20 laundry cycles in VP-ZPT. Additionally, VP-ZPT samples exhibited poor adherence of bacteria on the fabric surface. The functionalized fabrics may find applications for topical skin diseases in reducing the necessity of repeated use of antibiotic ointments.

Metal-Amino Acid Nanofibers based Triboelectric Nanogenerator for Self-Powered Thioacetamide Sensor.

The biomolecules offer different metal-binding sites to form a coordination polymer with structural diversity. The coordination directed one-dimensional metal-biomolecule nanofibers (Cu-Asp NFs) designed using copper as metal ion and aspartate as a ligand for triboelectric nanogenerator (TENG) is reported here. The different characterization techniques reveal the detailed characteristics of the synthesized Cu-Asp NFs. The robust coating of the Cu-Asp NFs is achieved using a simple tape cast coater. The bending and water dipping studies suggest the stability of the coated material. The relative polarity test and Kelvin probe force microscopy (KPFM) reveal the position of Cu-Asp in the triboelectric series. The Cu-Asp NFs and Teflon are used as the active material for the fabrication of freestanding mode (NF-TENG) and contact-separation mode (cNF-TENG) TENG. The NF-TENG generates an output of 200 V and 6 µA. The simple ion deposition technique enhances the voltage, current, and transferred charge of cNF-TENG by 2.5, 8, and 3 times. The use of the material for the single electrode sliding mode device further confirms the coated material's stability and robustness. A selective self-powered thioacetamide sensor is developed with the cNF-TENG, which exhibits a sensitivity of 0.76 v mM-1. Finally, NF-TENG is demonstrated for powering up numerous portable electronics.

A facile method for the phosphorylation of cellulosic fabric via atmospheric pressure plasma.

Green chemistry approach for phosphorylation of cellulose, under atmospheric pressure plasma was investigated and compared with conventional thermal method. The attachment of the phosphate groups was evaluated by 31P and 13C solid state NMR spectroscopy and XPS. The thermal method led to the formation of monophosphate of cellulose along with a side product of polymerized phosphate, whereas the plasma method produced only the monophosphate, without any side products. Unlike with the thermal treatment, the appearance and the mechanical properties of the viscose fabric remained nearly same after the plasma treatment. Also, the dyeability of the plasma modified fabric remained unchanged, whereas it decreased significantly in the thermally modified fabric. The amount of phosphate quantified by phosphomolybdate assay was found to be 2.88 ± 0.06 and 4.09 ± 0.19 % in the plasma and the thermal methods, respectively. This method has the potential to replace the existing methods of phosphorylation of cellulose.

Pretreatment of Leucaena leucocephala wood by acidified glycerol: optimization, severity index and correlation analysis.

In this study, Leucaena leucocephala wood was pretreated with aqueous glycerol having H2SO4 as the catalyst. Response surface methodology (RSM) and artificial neural network (ANN) were used to optimize the process parameters, catalyst concentration (1-3%), duration (120-300 min) and temperature (100-150 °C). ANN gave more accurate predictions for total reducing sugar yield than RSM. ANN also had lower values for error functions. Severity index (SI) was calculated based on the temperature, duration and catalyst concentration. Increase in SI from 0.21 * 103 to 2.06 * 103 increased total reducing sugar (TRS) production from 39.97 g/kg to 321.8 g/kg. Further increase in SI reduced the TRS and this change positively correlates with the loss of cellulose content. Correlation analysis showed that severity index can also be used to describe pretreatment process.

Taurine and its neuroprotective role.

Taurine plays multiple roles in the CNS including acting as a -neuro-modulator, an osmoregulator, a regulator of cytoplasmic calcium levels, a trophic factor in development, and a neuroprotectant. In neurons taurine has been shown to prevent mitochondrial dysfunction and to protect against endoplasmic reticulum (ER) stress associated with neurological disorders. In cortical neurons in culture taurine protects against excitotoxicity through reversing an increase in levels of key ER signaling components including eIF-2-alpha and cleaved ATF6. The role of communication between the ER and mitochondrion is also important and examples are presented of protection by taurine against ER stress together with prevention of subsequent mitochondrial initiated apoptosis.

Water quality assessment of Majhiaon block of Garwa district in Jharkhand with special focus on fluoride analysis.

Fluoride in groundwater is known to contaminate the water sources globally. Jharkhand, one of the states in the eastern part of India, is known to have excessive fluoride content in groundwater sources. The present work involves assessment of water quality with special reference to fluoride in Majhiaon block of Garwa district in Jharkhand. Iron, nitrate and arsenic were also tested for the water samples collected from site. Eight hundred forty samples were tested for fluoride on site using colourimetry method, and one tenth of the samples were brought to laboratory for iron, nitrate, arsenic and fluoride analysis. Results show that 402 samples were having fluoride above permissible limit. Iron and nitrate were found to be beyond permissible limits in 302 and 286 water samples, respectively. More than 50% of samples collected from school had fluoride levels above permissible limits. Arsenic was well within the limits. However, few samples shown were excessive of iron and nitrate.

Decreased Use of Antidepressants in Youth After US Food and Drug Administration Black Box Warning.

Objective. This study evaluates changes in use of antidepressants in children and adolescents after the US Food and Drug Administration black box warning for increased risk of suicide.Method. A retrospective chart review was completed for children and adolescents (ages 4-17) who were diagnosed with depressive or anxiety disorders in an outpatient clinic and offered a trial of antidepressants between September 2003 and February 2004 (before the black box warning) and between January 2005 and June 2005 (after the black box warning). Statistical analyses were performed with the SPSS version 17 and R package version 2.9.1. Univariate analysis was conducted using the Fisher's Exact test.Results. The odds ratio calculated for the different groups suggests that in all the groups, the proportion of acceptance of antidepressant use was greater before the black box warning as compared to after the black box warning (odds ratio>1). It was also found that upon combining the age groups after the warning and comparing them, based on the diagnoses, there was a greater degree of refusal of antidepressant therapy when a diagnosis of anxiety disorder was made as compared to a diagnosis of depressive disorder (p=0.017).Conclusion. There has been a decrease in the use of antidepressant therapy in children and adolescents following the US Food and Drug Administration black box warning for risk of suicide. A limitation of this study is that reasons for refusal of antidepressent therapy by parents or guardians of children and adolescents were not collected; therefore, there is no certainty that the black box warning was the primary reason for refusal.