Studies on Jackfruit-Okra Mucilage-Based Curcumin Mucoadhesive Tablet for Colon Targeted Delivery.

The present work investigates a blend of jack fruit mucilage (JFM) and okra mucilage (OKM) as promising mucoadhesive carriers for colon-specific delivery of a curcumin (CMN)-loaded mucoadhesive tablet (CMT) formulation. Formulation optimization was performed using central composite design (CCD) to further decipher the effect of varying proportions of the mucoadhesive carriers JFM and OKG on response factors such as drug release (% DR) and mucoadhesive strength (MA). The optimized formulation CMT (F14) demonstrated a favorable 54.35% in vitro release of CMN in 12 h with release kinetics resulting from a zero-order anomalous diffusion mechanism and MA of 34.1733 ± 1.26 g. Accelerated stability testing of CMT (F14) confirmed a shelf life of about 4.7 years. In vivo drug targeting studies performed using rabbit models in order to observe transit behavior (colon-specific delivery) of the dosage form were assessed by fluoroscopic images of the GI tract. Taking the results together, the results confirm that the combination of JFM and OKM could be exploited as an ideal mucoadhesive carrier for effective delivery of macromolecules to the colon.

Development and optimization of sustained release mucoadhesive composite beads for colon targeting.

The present work investigates a blend of Linum Seed mucilage(LSM) and Hibiscus Leaf gum(HLG) as mucoadhesive carriers for Capecitabine(CPTB) loaded mucoadhesive composite bead formulation (CMB), in an attempt to achieve sustained release of CPTB (BCS Class I drug) in the colon region. Optimization using Box-Behnken Design(BBD) was used to study the effect of quantities of mucoadhesive carriers(LSM,HLG) and enteric polymer pectin (in curing solution) on response factors such as %drug loading (%DL) and %drug release (%DR). CMB prepared by ion-gelation technique showed uniform bead size, spherical surface morphology, maximum drug encapsulation efficiency. The optimized CMB(F18) exhibited maximum %drug loading(28.94%), favorable in vitro drug release of CPTB(54.43%) in 12 h, where, the release kinetics follow zero order non-Fickian diffusion mechanism. CMB's exhibited significantly higher swelling upon exposure to alkaline media than acidic media similarly ex vivo mucoadhesive study also revealed that major fraction of beads were washed off within 2 h in 1.2pH media whereas in 7.4pH alkaline media major portion of the beads remain adhered even after 24 h Moreover accelerated stability testing of CMB(F18) revealed shelf life of about 2.59 years. Hence the study confirms that the combination of LSM&HLG as ideal mucoadhesive carriers and can favorably target highly soluble drugs to the colon region.