[The ulcerostatic effect of the exopolysaccharide from Bacillus mucilaginosus and its possible mechanisms]. / Ul'tserostaticheskii éffekt ékzopolisakharida slizeobrazuiushchikh batsill i ego vozmozhnye mekhanizmy.

The stimulatory action of Bacillus mucilaginosus exopolysaccharide on proliferative processes in experimental gastric ulcer healing. With the drug, the levels of collagen, noncollagen proteins, glycosaminoglycans, DNA, and RNA in the ulcer tissue.

[The antiatherosclerotic effects of a polysaccharide from raw animal stock]. / Antiateroskleroticheskie éffekty polisakharida iz zhivotnogo syr'ia.

The data obtained showed that the polysaccharide diminished the blood levels of cholesterol, beta-lipoproteins, and triglycerides, the concentrations of cholesterol in the liver and thoracic aorta in experimental atherosclerosis. It is concluded that the polysaccharide is promising in designing a new anti-atherosclerotic drug.

[Krezatsin--a stimulant of the activity of regenerating liver cells]. / Krezatsin--stimuliator aktivnosti regeneriruiushchikh kletok pecheni.

In experiments with partial hepatectomy in rats, the application of cresacin was shown to potentiate processes of hepatocyte regeneration, to increase high-energy compounds therein, and to accelerate some phases of mitotic cycle. These processes occur along with an inhibition of lipid peroxidation in hepatocytes, a decrease in the rate of transmembrane oxygen transport in mitochondria, and a reduction of cytochrome oxidase amount. It was concluded that cresacin directly stimulates diverse links of metabolic pathway.

[Solcoseryl: Ulcerostatic effect and possible mechanisms]. / Solkoseril: ul'tserostaticheskii éfekt i ego vozmozhnye mekhanizmy.

It is shown that the level of DNA, RNA, collagen, non-collagen proteins, hexoses and glycosaminoglycans is changed when making the experimental gastric ulcer in rats. Solcoseryl stabilises the level of DNA, RNA and collagen, stimulating the reparation processes in ulcer.

[Isopropoxyhermatran--a stimulant of hepatocyte regeneration]. / Izopropksigermatran--stimuliator regeneratsii gepatotsitov.

It was shown that isoproxihermatran (IPH) (40 mg/kg) administered intraperitoneally in rats with lobectomy of heparin stimulates development of hepatocytes' dimensions and decrease of oxygen transmission velocity through the mitochondrial membranes in this cells. Antioxidant properties of IPH have been detected. Stimulating activity of IPH at heparin secretion of bile.

[Ulcerostatic effect of tris-[2-hydroxyethyl] ammonium salt of iron-containing polyacryl acid and its possible mechanisms]. / Ul'tserostaticheskii éffekt tris-[2-oksiétil] ammoniinoi soli zhelezosoderzhashchei poliakrilovoi kisloty i ego vozmozhnye mekhanizmy.

The study investigated a stimulating effect of tris-[2-hydroxyethyl] ammonium salt of iron-containing polyacryl acid on proliferative processes in the connective tissue in development of experimental gastric ulcer. The drug was found to exhibit an ulcerostatic effect, to change the levels of collagen, noncollagen proteins, glycosaminoglycan fractions, DNA and RNA.

[Analysis of the mechanism of the ulcerostatic effect of tris-[2-hydroxyethyl] ammonium salt of iron-containing polyacrylic acid]. / Analiz mekhanizma ul'tserostaticheskogo deistviia tris-[2-oksiétil] ammoniinoi soli zhelezosoderzhashchei poliakrilovoi kisloty.

It was demonstrated in experiments on rats with acetate gastric ulcer that ammonium salt tris-(2-hydroxyethyl) of iron-containing polyacrylic acid intensifies the development of granulation-fibrous tissue and promotes fuller restoration of connective-tissue polymers--collagen, noncollagenous proteins, and glycosaminoglycans in it. The biochemical results are confirmed by histological studies.

[An analysis of the possible mechanism of the ulcerostatic action of 1-ethoxysilatrane]. / Analiz vozmozhnogo mekhanizma ul'tserostaticheskogo deistviia 1-étoksisilatrana.

Stimulating effect of 1-ethoxysilatrane on healing processes of experimental stomach ulcers was studied in rats. 1-ethoxysilatrane inhibited lipid peroxidation in blood and stomach wall tissues, interacted with artificial membranes, and affected the rate of mitochondrial respiration in liver. A hypothesis is put forward on the membranotropic effect of 1-ethoxysilatrane which underlies its ulcerostatic effect.

[A biochemical analysis of the possible mechanisms of the ulcerostatic action of atranes]. / Biokhimicheskii analiz vozmozhnykh mekhanizmov ul'tserostaticheskogo deistviia atranov.

Stimulatory effect of metalloatrans on the development of stomach wall connective tissue components was examined in rats with experimental acetate ulcer. Metalloatrans were shown to inhibit peroxide oxidation processes of lipids in blood and stomach tissue.

[Possible mechanisms of anti-ulcer action of silatranes]. / K voprosu o vozmozhnykh mekhanizmakh ul'tserostaticheskogo deistviia silatranov.

A stimulating effect of methylethyl(silatrane-I-ilmethyl)-sulphonium iodides, 1-(ethoxy)silatranes and 1-(chloromethyl)silatrane on the processes of rat test acetate ulcer healing is studied. Silatranes efficiency is not inferior to oxyferriscorbone and exceeds that of methacil. It is shown that all preparations inhibit the processes of lipids peroxidation in the blood, in liposomes and stomach tissue.

[An analysis of the action of metalloatranes on the hypothalamic neurons of rats]. / Analiz deistviia metalloatranov na neirony gipotalamusa u krys.

Neurophysiological effects of different metal derivatives of atranes at single and repeated introduction into rats have been studied. Spontaneous activity of separate hypothalamic neurons was found to change at introduction of atranes. Discharge activity of hypothalamic [correction of pretubercular] cells changed both in phasic and in tonic mode in response to single injection of atranes. The data obtained allow to conclude that metal derivatives of atranes do not exert specific effect on hypothalamic neurons.

[1-Ethoxysilatrane: ulcerostatic effect and its possible mechanisms]. / 1-Etoksisilatran: ul'tserostaticheskii éffekt i ego vozmozhnye mekhanizmy.

Stimulating effect of I-ethoxy silatrane on healing of acetate derived stomach ulcer was studied in rats. The drug was shown to inhibit lipid peroxidation and free-radical oxidation in blood and gastric tissues as well as to accelerate reparation in ulcerous zone. I-Ethoxy silatrane interacted with artificial membranes and affected the respiration rate in liver mitochondria. Membranetropic effect of I-ethoxy silatrane appears to be involved in the drug ulcerostatic effect.

[Atranes: their ulcerostatic effect and its possible mechanisms]. / Atrany: ul'tserogstaticheskiiéffekt i ego vozmozhnye mekhanizmy.

The ulcerostatic activity of methylethyl (sylathrane-1-ilmethyl) sulfoiodide, 1-(chlormethyl) sylatrane, and 1-(isopropoxy)hermatrane has been revealed at experimental acetate ulcer in rats. The effect of atranes was equal to that of oxyferriscorbone and exceeded that of methyluracil. All the compounds studied inhibited peroxide oxidation of lipids in blood and stomach tissues from ulcer and in model experiments in egg yolk liposomes. The processes of ulcer development and photodynamic effects of lipid peroxidation in biological objects have been summarized. The data obtained allow to conclude that the ulcerostatic mechanism of action effect of atranes and the comparable drugs is based on their antioxidative effect.

[The anticoagulant and antisclerotic effects of isopropoxygermatrane and methylethyl(silatrane-1-ylmethyl)sulfonium iodide]. / Antikoaguliantnye i antiskleroticheskie éffekty izopropoksigermatrana i metilétil (silatran-1-ilmetil[sul'fonii iodida.

In the experiments on rabbits with experimental atherosclerosis the authors revealed lipolytic and antisclerotic effect of the above drug. It was also observed that it also possessed anticoagulation activity.