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1.
Endoscopy ; 51(8): 750-758, 2019 08.
Artículo en Inglés | MEDLINE | ID: mdl-31195423

RESUMEN

INTRODUCTION: Because individuals with serrated polyps and adenomas are at increased risk of developing new polyps and colorectal cancer (CRC), surveillance after resection is justified. After adenoma resection, most international guidelines are consistent, but recommendations for surveillance after serrated polyp resection vary. The United States Multi-Society Taskforce on CRC (US-MSTF) base surveillance intervals on serrated polyp subtype (traditional serrated adenoma, sessile serrated polyp, hyperplastic polyps), while the European Society of Gastrointestinal Endoscopy (ESGE) guidelines do not take serrated polyp subtype into account. We evaluated the implications of this difference in a primary colonoscopy screening cohort. METHODS: We included participants from a large colonoscopy screening trial. In a post-hoc simulation, assuming full protocol adherence, we determined the surveillance interval for each subject based on their polyp burden, using the most recent US-MSTF and ESGE guidelines. RESULTS: We included 5323 participants, of whom 1228 had one or more serrated polyps. In 5201 of all participants (98 %; Cohen's kappa 0.90) and in 1106 of those with serrated polyps (90 %; Cohen's kappa 0.80), both guidelines recommended identical surveillance intervals. Recommendations for a 3-year surveillance interval were identical between the two guidelines. All 122 subjects with discordant recommendations would receive a follow-up colonoscopy after 10 years using ESGE guidance and after 5 years using US-MSTF guidance. CONCLUSION: Despite the different criteria used to determine surveillance after serrated polyp resection, most individuals are recommended identical colonoscopy surveillance intervals whether following the ESGE or US-MSTF guidelines. This suggests that surveillance recommendations do not need to consider the serrated polyp subtype.


Asunto(s)
Adenoma/diagnóstico por imagen , Pólipos del Colon/diagnóstico por imagen , Colonoscopía , Neoplasias Colorrectales/diagnóstico por imagen , Vigilancia de la Población , Guías de Práctica Clínica como Asunto , Adenoma/epidemiología , Adenoma/patología , Pólipos del Colon/epidemiología , Pólipos del Colon/patología , Neoplasias Colorrectales/epidemiología , Neoplasias Colorrectales/patología , Europa (Continente)/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Estados Unidos/epidemiología
2.
Am J Physiol Lung Cell Mol Physiol ; 316(6): L999-L1012, 2019 06 01.
Artículo en Inglés | MEDLINE | ID: mdl-30908936

RESUMEN

Lung diseases with hypoxia are complicated by pulmonary hypertension, leading to heart failure and death. No pharmacological treatment exists. Increased proinflammatory cytokines are found in hypoxic patients, suggesting an inflammatory pathogenesis. Caspase-1, the effector of the inflammasome, mediates inflammation through activation of the proinflammatory cytokines interleukin (IL)-18 and IL-1ß. Here, we investigate inflammasome-related mechanisms that can trigger hypoxia-induced pulmonary hypertension. Our aim was to examine whether caspase-1 induces development of hypoxia-related pulmonary hypertension and is a suitable target for therapy. Wild-type (WT) and caspase-1-/- mice were exposed to 10% oxygen for 14 days. Hypoxic caspase-1-/- mice showed lower pressure and reduced muscularization in pulmonary arteries, as well as reduced right ventricular remodeling compared with WT. Smooth muscle cell (SMC) proliferation was reduced in caspase-1-deficient pulmonary arteries and in WT arteries treated with a caspase-1 inhibitor. Impaired inflammation was shown in hypoxic caspase-1-/- mice by abolished pulmonary influx of immune cells and lower levels of IL-18, IL-1ß, and IL-6, which were also reduced in the medium surrounding caspase-1 abrogated pulmonary arteries. By adding IL-18 or IL-1ß to caspase-1-deficient pulmonary arteries, SMC proliferation was retained. Furthermore, inhibition of both IL-6 and phosphorylated STAT3 reduced proliferation of SMC in vitro, indicating IL-18, IL-6, and STAT3 as downstream mediators of caspase-1-induced SMC proliferation in pulmonary arteries. Caspase-1 induces SMC proliferation in pulmonary arteries through the caspase-1/IL-18/IL-6/STAT3 pathway, leading to pulmonary hypertension in mice exposed to hypoxia. We propose that caspase-1 inhibition is a potential target for treatment of pulmonary hypertension.


Asunto(s)
Caspasa 1/genética , Hipoxia de la Célula/fisiología , Hipertensión Pulmonar/patología , Miocitos del Músculo Liso/fisiología , Función Ventricular Derecha/fisiología , Animales , Línea Celular , Proliferación Celular/genética , Humanos , Inflamasomas/metabolismo , Interleucina-18/metabolismo , Interleucina-1beta/metabolismo , Interleucina-6/metabolismo , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Noqueados , Músculo Liso Vascular/citología , Músculo Liso Vascular/crecimiento & desarrollo , Arteria Pulmonar/citología , Arteria Pulmonar/patología , Factor de Transcripción STAT3/metabolismo
3.
Clin Case Rep ; 7(1): 64-70, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30656010

RESUMEN

Though rare in cervical cancer patients, paraneoplastic syndrome usually presents with several endocrine and hormonal symptoms. Knowledge of the pathophysiology that underlies these abnormalities is beneficial to diagnosis and treatment. An interdisciplinary approach and test analysis prior to initiating specific treatment is recommended, though prognosis appears poor in advanced cases.

4.
Pediatr Res ; 70(4): 352-6, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21691250

RESUMEN

Neonatal hypoxic-ischemic encephalopathy (HIE) is a clinically defined neurological condition after lack of oxygen and often associated with cardiac dysfunction in term infants. Therapeutic hypothermia (HT) after birth is neuroprotective in infants with HIE. However, it is not known whether HT is also cardioprotective. Four newborn pigs were used in the pilot study and a further 18 newborn pigs [randomly assigned to 72 h normothermia (NT) or 24 h HT followed by 48 h NT] were subjected to global HIE insults. Serum cTnI was measured before and post the HIE insult. Blood pressure, inotropic support, blood gases, and heart rate (HR) were recorded throughout. Cardiac pathology was assessed from histological sections. Cooling reduced serum cTnI levels significantly in HT pigs by 6 h (NT, 1.36 ± 0.67; HT, 0.34 ± 0.23 ng/mL; p = 0.0009). After rewarming, from 24 to 30 h postinsult, HR and cTnI increased in the HT group; from HR[24 h] = 117 ± 22 to HR[30 h] = 218 ± 32 beats/min (p = 0.0002) and from cTnI[24 h] = 0.23 ± 0.12 to cTnI[30 h] = 0.65 ± 0.53 ng/mL, (p = 0.05). There were fewer ischemic lesions on cardiac examination (37%) in the HT group compared with the NT group (70%). HT (24 h) pigs did not have the postinsult cTnI increase seen in NT-treated pigs. There was a trend that HT improved cardiac pathology in this 3-d survival model.


Asunto(s)
Hipotermia Inducida , Hipoxia-Isquemia Encefálica/fisiopatología , Hipoxia-Isquemia Encefálica/terapia , Miocardio/metabolismo , Troponina I/sangre , Animales , Animales Recién Nacidos , Presión Sanguínea/fisiología , Temperatura Corporal/fisiología , Humanos , Miocardio/patología , Proyectos Piloto , Distribución Aleatoria , Porcinos
5.
J Matern Fetal Neonatal Med ; 22(2): 161-8, 2009 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-19253165

RESUMEN

OBJECTIVE: We wished to assess the effect of global hypoxia and the effect of nicotine pretreatment on the brain and heart of newborn pigs. Hypothesising that nicotine might give a better outcome because of its anti-apoptotic and anti-inflammatory effects. METHODS: Twenty-two anaesthetised piglets were randomised to pretreatment with saline or nicotine (130 microg/kg/h) before 45 min global hypoxia. They were observed for 27 h. The brain and heart were assessed with histopathological methods. Serum for Troponin t (TnT) analyses was collected at baseline and at the end of the experiment. RESULTS: There were no significant differences between the groups. At the end of hypoxia, BE was -14.8 +/- 4.9 mmol/l and MABP was 25 +/- 9 mmHg. Seven animals had autolysis of the cerebrum/cerebellum, their BE after hypoxia was -19 +/- 1.8 mmol/l and MABP 23 +/- 3 mmHg. The remaining 15 animals had a BE of -13 +/- 4.7mmol/l (p = 0.0004) and a MABP of 26 +/- 11 mmHg (ns). Eleven animals presented myocardial damage. A significant increase in TnT occurred in both groups. TnT increase and myocardial damage correlated (p = 0.001; r = 0.67). Animals with severe increase in TnT presented severe brain damage. CONCLUSIONS: Severe increase in serum TnT levels was linked to severe cerebral damage. Nicotine pretreatment had no impact on cerebral or cardiac histopathology.


Asunto(s)
Encéfalo/patología , Hipoxia/patología , Miocardio/patología , Nicotina/farmacología , Agonistas Nicotínicos/farmacología , Premedicación , Animales , Animales Recién Nacidos , Autólisis , Presión Sanguínea , Femenino , Frecuencia Cardíaca , Hipoxia Encefálica/sangre , Masculino , Infarto del Miocardio/patología , Distribución Aleatoria , Solución Salina Hipertónica/farmacología , Índice de Severidad de la Enfermedad , Porcinos , Troponina T/sangre
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