Noninvasive brain stimulation in autism: review and outlook for personalized interventions in adult patients.

Noninvasive brain stimulation (NIBS) has been increasingly investigated during the last decade as a treatment option for persons with autism spectrum disorder (ASD). Yet, previous studies did not reach a consensus on a superior treatment protocol or stimulation target. Persons with ASD often suffer from social isolation and high rates of unemployment, arising from difficulties in social interaction. ASD involves multiple neural systems involved in perception, language, and cognition, and the underlying brain networks of these functional domains have been well documented. Aiming to provide an overview of NIBS effects when targeting these neural systems in late adolescent and adult ASD, we conducted a systematic search of the literature starting at 631 non-duplicate publications, leading to six studies corresponding with inclusion and exclusion criteria. We discuss these studies regarding their treatment rationale and the accordingly chosen methodological setup. The results of these studies vary, while methodological advances may allow to explain some of the variability. Based on these insights, we discuss strategies for future clinical trials to personalize the selection of brain stimulation targets taking into account intersubject variability of brain anatomy as well as function.

Micropoetry Meets Neurocognitive Poetics: Influence of Associations on the Reception of Poetry.

Reading and understanding poetic texts is often described as an interactive process influenced by the words and phrases building the poems and all associations and images induced by them in the readers mind. Iser, for example, described the understanding process as the closing of a good Gestalt promoted by mental images. Here, we investigate the effect that semantic cohesion, that is the internal connection of a list words, has on understanding and appreciation of poetic texts. To do this, word lists are presented as modern micropoems to the participants and the (ease of) extraction of underlying concepts as well as the affective and aesthetic responses are implicitly and explicitly measured. We found that a unifying concept is found more easily and unifying concepts vary significantly less between participants when the words composing a micropoem are semantically related. Moreover these items are liked better and are understood more easily. Our study shows evidence for the assumed relationship between building spontaneous associations, forming mental imagery, and understanding and appreciation of poetic texts. In addition, we introduced a new method well-suited to manipulate backgrounding features independently of foregrounding features which allows to disentangle the effects of both on poetry reception.

Sentiment Analysis of Children and Youth Literature: Is There a Pollyanna Effect?

If the words of natural human language possess a universal positivity bias, as assumed by Boucher and Osgood's (1969) famous Pollyanna hypothesis and computationally confirmed for large text corpora in several languages (Dodds et al., 2015), then children and youth literature (CYL) should also show a Pollyanna effect. Here we tested this prediction applying an unsupervised vector space model-based sentiment analysis tool called SentiArt (Jacobs, 2019) to two CYL corpora, one in English (372 books) and one in German (500 books). Pitching our analysis at the sentence level, and assessing semantic as well as lexico-grammatical information, both corpora show the Pollyanna effect and thus add further evidence to the universality hypothesis. The results of our multivariate sentiment analyses provide interesting testable predictions for future scientific studies of literature.

From Abstract Symbols to Emotional (In-)Sights: An Eye Tracking Study on the Effects of Emotional Vignettes and Pictures.

Reading is known to be a highly complex, emotion-inducing process, usually involving connected and cohesive sequences of sentences and paragraphs. However, most empirical results, especially from studies using eye tracking, are either restricted to simple linguistic materials (e.g., isolated words, single sentences) or disregard valence-driven effects. The present study addressed the need for ecologically valid stimuli by examining the emotion potential of and reading behavior in emotional vignettes, often used in applied psychological contexts and discourse comprehension. To allow for a cross-domain comparison in the area of emotion induction, negatively and positively valenced vignettes were constructed based on pre-selected emotional pictures from the Nencki Affective Picture System (NAPS; Marchewka et al., 2014). We collected ratings of perceived valence and arousal for both material groups and recorded eye movements of 42 participants during reading and picture viewing. Linear mixed-effects models were performed to analyze effects of valence (i.e., valence category, valence rating) and stimulus domain (i.e., textual, pictorial) on ratings of perceived valence and arousal, eye movements in reading, and eye movements in picture viewing. Results supported the success of our experimental manipulation: emotionally positive stimuli (i.e., vignettes, pictures) were perceived more positively and less arousing than emotionally negative ones. The cross-domain comparison indicated that vignettes are able to induce stronger valence effects than their pictorial counterparts, no differences between vignettes and pictures regarding effects on perceived arousal were found. Analyses of eye movements in reading replicated results from experiments using isolated words and sentences: perceived positive text valence attracted shorter reading times than perceived negative valence at both the supralexical and lexical level. In line with previous findings, no emotion effects on eye movements in picture viewing were found. This is the first eye tracking study reporting superior valence effects for vignettes compared to pictures and valence-specific effects on eye movements in reading at the supralexical level.

What Is the Difference? Rereading Shakespeare's Sonnets -An Eye Tracking Study.

Texts are often reread in everyday life, but most studies of rereading have been based on expository texts, not on literary ones such as poems, though literary texts may be reread more often than others. To correct this bias, the present study is based on two of Shakespeare's sonnets. Eye movements were recorded, as participants read a sonnet then read it again after a few minutes. After each reading, comprehension and appreciation were measured with the help of a questionnaire. In general, compared to the first reading, rereading improved the fluency of reading (shorter total reading times, shorter regression times, and lower fixation probability) and the depth of comprehension. Contrary to the other rereading studies using literary texts, no increase in appreciation was apparent. Moreover, results from a predictive modeling analysis showed that readers' eye movements were determined by the same critical psycholinguistic features throughout the two sessions. Apparently, even in the case of poetry, the eye movement control in reading is determined mainly by surface features of the text, unaffected by repetition.

Eye movements and mental imagery during reading of literary texts with different narrative styles.

Based on Kuzmicová's [1] phenomenological typology of narrative styles, we studied the specific contributions of mental imagery to literary reading experience and to reading behavior by combining questionnaires with eye-tracking methodology. Specifically, we focused on the two main categories in Kuzmicová's [1] typology, i.e., texts dominated by an "enactive" style, and texts dominated by a "descriptive" style. "Enactive" style texts render characters interacting with their environment, and "descriptive" style texts render environments dissociated from human action. The quantitative analyses of word category distributions of two dominantly enactive and two dominantly descriptive texts indicated significant differences especially in the number of verbs, with more verbs in enactment compared to descriptive texts. In a second study, participants read two texts (one theoretically cueing descriptive imagery, the other cueing enactment imagery) while their eye movements were recorded. After reading, participants completed questionnaires assessing aspects of the reading experience generally, as well as their text-elicited mental imagery specifically. Results show that readers experienced more difficulties conjuring up mental images during reading descriptive style texts and that longer fixation duration on words were associated with enactive style text. We propose that enactive style involves more imagery processes which can be reflected in eye movement behavior.

The SLS-Berlin: Validation of a German Computer-Based Screening Test to Measure Reading Proficiency in Early and Late Adulthood.

Reading proficiency, i.e., successfully integrating early word-based information and utilizing this information in later processes of sentence and text comprehension, and its assessment is subject to extensive research. However, screening tests for German adults across the life span are basically non-existent. Therefore, the present article introduces a standardized computerized sentence-based screening measure for German adult readers to assess reading proficiency including norm data from 2,148 participants covering an age range from 16 to 88 years. The test was developed in accordance with the children's version of the Salzburger LeseScreening (SLS, Wimmer and Mayringer, 2014). The SLS-Berlin has a high reliability and can easily be implemented in any research setting using German language. We present a detailed description of the test and report the distribution of SLS-Berlin scores for the norm sample as well as for two subsamples of younger (below 60 years) and older adults (60 and older). For all three samples, we conducted regression analyses to investigate the relationship between sentence characteristics and SLS-Berlin scores. In a second validation study, SLS-Berlin scores were compared with two (pseudo)word reading tests, a test measuring attention and processing speed and eye-movements recorded during expository text reading. Our results confirm the SLS-Berlin's sensitivity to capture early word decoding and later text related comprehension processes. The test distinguished very well between skilled and less skilled readers and also within less skilled readers and is therefore a powerful and efficient screening test for German adults to assess interindividual levels of reading proficiency.

Reading Shakespeare Sonnets: Combining Quantitative Narrative Analysis and Predictive Modeling -an Eye Tracking Study.

As a part of a larger interdisciplinary project on Shakespeare sonnets' reception (1, 2), the present study analyzed the eye movement behavior of participants reading three of the 154 sonnets as a function of seven lexical features extracted via Quantitative Narrative Analysis (QNA). Using a machine learning-based predictive modeling approach five 'surface' features (word length, orthographic neighborhood density, word frequency, orthographic dissimilarity and sonority score) were detected as important predictors of total reading time and fixation probability in poetry reading. The fact that one phonological feature, i.e., sonority score, also played a role is in line with current theorizing on poetry reading. Our approach opens new ways for future eye movement research on reading poetic texts and other complex literary materials(3).

Eye movements during the reading of narrative and poetic texts. Symposium 6 at the 20th European Conference on Eye Movement Research (ECEM) in Alicante, 21.8.2019.

Despite a wealth of studies using eye tracking to investigate mental processes during vision or reading, the investigation of oculomotor activity during natural reading of longer texts -be it newspaper articles, narratives or poetry- is still an exception in this field (as evidenced by the program of ECEM 2017 in Wuppertal). Following up on our symposium at ECEM 2017, here we bring together eye movement research on natural text reading to report recent progress in a coordinated way sharing data, experiences and software skills in this highly complex subfield. More specifically, in this symposium we will address several challenges faced by an eye tracking perspective on the reading of longer texts which involve a surplus of intervening variables and novel methods to analyze the data. In particular, the following issues will be addressed: - Which text-analytical and statistical methods are best to deal with the myriad of surface and affective semantic features potentially influencing eye movements during reading of 'natural' texts? - What are the pros and cons of using machine learning assisted predictive modeling as an alternative to the standard GLM/LMM frameworks? - Which kind of theoretical models can deal with the level of complexity offered by reading longer natural texts? Video stream: https://vimeo.com/358415199.

Impact of quality of life (QoL) on glycemic control (HbA1c) among adolescents and emerging adults with long-duration type 1 diabetes: A prospective cohort-study.

OBJECTIVE: To evaluate the impact of self-reported chronic-generic and condition-specific quality of life (QoL) on glycemic control among adolescents and emerging adults with long-duration type 1 diabetes (T1D) in a longitudinal design. METHODS: The database used was a nationwide cohort study of patients with ≥10 years T1D duration at baseline in Germany. The baseline questionnaire survey was conducted in 2009-2010, the follow-up survey in 2012-2013; additional clinical data of routine care procedures were linked. QoL was assessed by the DISABKIDS chronic generic module (DCGM-12) and diabetes module (DM) with treatment and impact scales. Regression analyses were conducted for the outcome hemoglobin A1c (HbA1c) at follow up with baseline DISABKIDS scores as predictors and sociodemographic and health-related covariates. RESULTS: At baseline, the included 560 patients had a mean age of 15.9 (SD 2.3) years, a diabetes duration of 13.0 (2.0) years, and an HbA1c of 67 (14.2) mmol/mol. Mean follow-up time was 3.0 (0.6) years. Univariate analyses indicated associations between baseline QoL scores and HbA1c at follow-up (ß[DCGM-12] = -0.174 (SE 0.038), ß[DM treatment] = -0.100 (0.022), ß[DM impact] = -0.177 (0.030), p < .001). The associations remained significant after adjustment for sociodemographic and illness-related factors, but dissolved (p > .60) when additionally adjusting for baseline HbA1c. In patients with poor baseline HbA1c (>75 mmol/mol), significant associations were observed between DCGM-12 and DM impact scores and follow-up HbA1c (ß[DCGM-12] = -0.144 (0.062), p = .021; ß[DM impact] = -0.139 (0.048), p = .004). CONCLUSIONS: QoL was inversely associated with HbA1c after 3 years in the course of T1D only in patients poorly controlled at baseline.

The emotion potential of simple sentences: additive or interactive effects of nouns and adjectives?

The vast majority of studies on affective processes in reading focus on single words. The most robust finding is a processing advantage for positively valenced words, which has been replicated in the rare studies investigating effects of affective features of words during sentence or story comprehension. Here we were interested in how the different valences of words in a sentence influence its processing and supralexical affective evaluation. Using a sentence verification task we investigated how comprehension of simple declarative sentences containing a noun and an adjective depends on the valences of both words. The results are in line with the assumed general processing advantage for positive words. We also observed a clear interaction effect, as can be expected from the affective priming literature: sentences with emotionally congruent words (e.g., The grandpa is clever) were verified faster than sentences containing emotionally incongruent words (e.g., The grandpa is lonely). The priming effect was most prominent for sentences with positive words suggesting that both, early processing as well as later meaning integration and situation model construction, is modulated by affective processing. In a second rating task we investigated how the emotion potential of supralexical units depends on word valence. The simplest hypothesis predicts that the supralexical affective structure is a linear combination of the valences of the nouns and adjectives (Bestgen, 1994). Overall, our results do not support this: The observed clear interaction effect on ratings indicate that especially negative adjectives dominated supralexical evaluation, i.e., a sort of negativity bias in sentence evaluation. Future models of sentence processing thus should take interactive affective effects into account.

10 years of BAWLing into affective and aesthetic processes in reading: what are the echoes?

Reading is not only "cold" information processing, but involves affective and aesthetic processes that go far beyond what current models of word recognition, sentence processing, or text comprehension can explain. To investigate such "hot" reading processes, standardized instruments that quantify both psycholinguistic and emotional variables at the sublexical, lexical, inter-, and supralexical levels (e.g., phonological iconicity, word valence, arousal-span, or passage suspense) are necessary. One such instrument, the Berlin Affective Word List (BAWL) has been used in over 50 published studies demonstrating effects of lexical emotional variables on all relevant processing levels (experiential, behavioral, neuronal). In this paper, we first present new data from several BAWL studies. Together, these studies examine various views on affective effects in reading arising from dimensional (e.g., valence) and discrete emotion features (e.g., happiness), or embodied cognition features like smelling. Second, we extend our investigation of the complex issue of affective word processing to words characterized by a mixture of affects. These words entail positive and negative valence, and/or features making them beautiful or ugly. Finally, we discuss tentative neurocognitive models of affective word processing in the light of the present results, raising new issues for future studies.

"The drawer is still closed": simulating past and future actions when processing sentences that describe a state.

In two experiments using the action-sentence-compatibility paradigm we investigated the simulation processes that readers undertake when processing state descriptions with adjectives (e.g., Die Schublade ist offen/zu. [The drawer is open/shut]) or adjectival passives (e.g., Die Schublade ist geöffnet/geschlossen. [The drawer is opened/closed]). In Experiment 1 we did not find evidence for action simulation, not even in sentences with adjectival passives. The results were different in Experiment 2, where the temporal particle noch (still/yet) was inserted into the sentences (e.g., The drawer is still closed). Under these circumstances readers mentally simulated the action that brought about the current state for sentences with adjectival passives, but the action that would change the current state for sentences with adjectives. Thus, comprehenders are in principle sensitive to the subtle differences between adjectives and adjectival passives but highlighting the temporal dimension of the described states of affairs seems a necessary precondition for obtaining evidence for action simulation with sentences that describe a state. We discuss implications for future studies employing neuro-psychological methods.

Event-related potential correlates of negation in a sentence-picture verification paradigm.

In a sentence-picture verification paradigm, participants were presented in a rapid-serial-visual-presentation paradigm with affirmative or negative sentences (e.g., "In the front of the tower there is a/no ghost") followed by a matching or mismatching picture. Response latencies and event-related potentials (ERPs) were measured during reading and verification. An enhanced negative shift in the ERPs for the subject noun (i.e., "ghost") in negative, compared to affirmative sentences, was found during reading. We relate this ERP deflection to enhanced processing demands required by the negative particle no. Although this effect suggests a direct impact of negation on language processing, results for picture processing reveal that negation is not immediately integrated into sentence meaning. When the delay of picture presentation was short (250 msec), verification latencies and ERPs evoked by the picture showed a priming effect independent of whether the sentence contained a negation. Unprimed pictures (foreground object not mentioned in the sentence) led to longer latencies and higher N400 amplitudes than primed pictures (foreground object mentioned in the sentence). Main effects of negation showed up only in a late positive-going ERP effect. In contrast, when the delay was long (1500 msec), we observed main effects of truth value and negation in addition to the priming effect already in the N400 time window, that is, negation is fully integrated into sentence meaning only at a later point in the comprehension process. When negation has not yet been integrated, verification decisions appear to be modulated by additional time-consuming reanalysis processes.

Experiential simulations of negated text information.

We investigated the question of whether comprehenders mentally simulate a described situation even when this situation is explicitly negated in the sentence. In two experiments, participants read negative sentences such as There was no eagle in the sky, and subsequently responded to pictures of mentioned entities in the context of a recognition task. Participants' responses following negative sentences were faster when the depicted entity matched rather than mismatched the negated situation. These results suggest that comprehenders simulate the negated situation when processing a negated sentence. The results thereby provide further support for the experiential-simulations view of language comprehension.