Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study.

INTRODUCTION: Acne vulgaris (acne) is characterized by both inflammatory and non-inflammatory lesions. Benzoyl peroxide (BPO) 5% is approved to treat acne but may cause skin irritation and/or contact allergy. OBJECTIVES: To compare the benefit in acne of a multitargeted dermocosmetic cream containing salicylic acid, lipohydroxy acid, niacinamide, 2-oleamido-1,3-octadecanediol, piroctone olamine, zinc, Aqua posae filiformis, and thermal spring water (DC-Eff) to BPO 5% gel. MATERIALS AND METHODS: 150 Caucasian subjects (50% female) aged between 18 and 40 years, with mild to moderate acne according to the GEA (Global Evaluation of Acne) grading system were randomized into two parallel groups (DC-Eff or BPO to be applied twice daily for 56 days). IGA (investigator global assessment), GEA, lesion count, clinical signs and symptoms, and subject assessment were evaluated at baseline, and after 28 and 56 days (D28 and D56) of treatment. RESULTS: The responder analyses of the IGA and GEA scores showed that 62.2% and 47.3%, respectively, in the DC-Eff, compared with 50.0% and 36.5%, respectively, in the BPO, had improved by at least one point at D56. Inflammatory, non-inflammatory, and total lesion counts significantly (p < 0.0001) decreased with both products from baseline, with no between-group difference. Subjects considered that their skin was smoother and that DC-Eff was easy to apply. DC-Eff was better tolerated than BPO. CONCLUSIONS: DC-Eff applied twice daily is as beneficial as BPO in improving mild-to-moderate acne. DC-Eff was better tolerated than BPO and highly appreciated.

Attributions and affirmations for overcoming anxiety and depression.

Individuals who struggle with anxiety or depression often turn to experts for help in overcoming these disorders. In this study, we consult three expert 'populations': the popular self-help literature, well-respected therapists, and individuals who believe that they have successfully recovered from either anxiety or depression for their recommendations to those who are currently anxious or depressed. In Part I, we content-analyse recommendations from 10 current self-help books on anxiety and 10 on depression. In Part II, we asked 17 respected therapists and 18 individuals who believed that they have recovered from anxiety and 23 individuals who believe they have recovered from depression what they believe are the 'keys' for recovery. We also asked them to rate the efficacy of seven popular affirmations. Through content analysis and descriptive statistics, we summarize their collective wisdom. Among the main findings are the recommendations for anxious and depressed individuals to actively seek help from multiple people and interventions, as well as to being open to trying innovative self-tailored interventions. Affirmations relating to 'not being crazy' in relation to anxiety and that the depression will subside in time were deemed most helpful for recovery. Discussion focuses on practical application.