Asunto(s)
Etinilestradiol/farmacología , Presión Intraocular/efectos de los fármacos , Progesterona/farmacología , Testosterona/farmacología , Animales , Aotus trivirgatus , Humor Acuoso/efectos de los fármacos , Femenino , Haplorrinos , Masculino , Noretindrona/farmacología , Norpregnadienos/farmacología , ConejosAsunto(s)
Catecolaminas/farmacología , Presión Intraocular/efectos de los fármacos , Animales , Relación Dosis-Respuesta a Droga , Epinefrina/antagonistas & inhibidores , Epinefrina/farmacología , Haplorrinos , Humanos , Isoproterenol/farmacología , Modelos Biológicos , Norepinefrina/farmacología , Receptores Adrenérgicos beta , Sotalol/farmacologíaRESUMEN
The intraocular pressure of conscious, unsedated owl monkeys (Aotus trivirgatus) was measured with an applanation tonometer. Untreated eyes of the conscious animals were found to have higher values than those reported for owl monkeys anesthetized with pentobarbitone. Locally applied pilocarpine, carbachol, and oxotremorine gave concentration-related reduction in pressure, oxotremorine being the most potent and having longer duration of effect than the other compounds. Slight reductions were also observed with aceclidine and R. S. 86. These results are discussed in relation to the effects of miotics in man.
Asunto(s)
Presión Intraocular/efectos de los fármacos , Mióticos/farmacología , Anestesia Local , Animales , Aotus trivirgatus , Carbacol/farmacología , Relación Dosis-Respuesta a Droga , Haplorrinos , Masculino , Oxotremorina/farmacología , Parasimpaticomiméticos , Pilocarpina/farmacología , Quinuclidinas/farmacología , Compuestos de Espiro/farmacología , Succinimidas/farmacología , Tonometría OcularRESUMEN
Enhancement by acetylcholine and by pilocarpine of the contractile responses of the guinea-pig isolated vas deferens to hypogastric nerve and transmural stimulation and to exogenous (minus)-noradrenaline was examined. At high concentration (600 nM) acetylcholine enhanced responses in the order:hypogastric nerve greater than transmural greater than exogenous (minus)-noradrenaline. Pilocarpine produced a similar maximal degree of enchancement with all three stimuli. All these effects were reversibly inhibited by 1-4 mum atropine, a concentration which alone did not affected responses to the stimuli. Pilocarpine (50-400 muM) gave a concentration-related inhibition of the enhancement of responses to hypogastric nerve stimulation by 600 nM acetylcholine.
