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2.
BMJ Open ; 13(1): e066286, 2023 01 06.
Artículo en Inglés | MEDLINE | ID: mdl-36609324

RESUMEN

INTRODUCTION: There is a discrepancy in the literature as to whether authorising or refusing the recovery of organs for transplantation is of direct benefit to families in their subsequent grieving process. This study aims to explore the impact of the family interview to pose the option of posthumous donation and the decision to authorise or refuse organ recovery on the grieving process of potential donors' relatives. METHODS AND ANALYSIS: A protocol for mixed methods, prospective cohort longitudinal study is proposed. Researchers do not randomly assign participants to groups. Instead, participants are considered to belong to one of three groups based on factors related to their experiences at the hospital. In this regard, families in G1, G2 and G3 would be those who authorised organ donation, declined organ donation or were not asked about organ donation, respectively. Their grieving process is monitored at three points in time: 1 month after the patient's death, when a semistructured interview focused on the lived experience during the donation process is carried out, 3 months and 9 months after the death. At the second and third time points, relatives' grieving process is assessed using six psychometric tests: State-Trait Anxiety Inventory, Beck Depression Inventory-II, Inventory of Complicated Grief, The Impact of Event Scale: Revised, Posttraumatic Growth Inventory and Connor-Davidson Resilience Scale. Descriptive statistics (means, SDs and frequencies) are computed for each group and time point. Through a series of regression models, differences between groups in the evolution of bereavement are estimated. Additionally, qualitative analyses of the semistructured interviews are conducted using the ATLAS.ti software. ETHICS AND DISSEMINATION: This study involves human participants and was approved by Comité Coordinador de Ética de la Investigación Biomédica de Andalucía (CCEIBA) ID:1052-N-21. The results will be disseminated at congresses and ordinary academic forums. Participants gave informed consent to participate in the study before taking part.


Asunto(s)
Aflicción , Obtención de Tejidos y Órganos , Humanos , Estudios Prospectivos , Estudios Longitudinales , España , Familia , Pesar , Donantes de Tejidos
6.
J Trauma ; 67(6): 1220-4, 2009 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-20009670

RESUMEN

INTRODUCTION: Preload parameters in postresuscitation phase are not sufficiently sensitive to guide fluid therapy in critically ill patients. We analyzed modifications in the fluid therapy and vasoactive drugs of critically ill patients that were produced by inclusion of extravascular lung water (EVLW) data in the treatment protocol and evaluated the short-term response. METHODS: This observational and prospective study included consecutive patients with hypotension or hypoxemia, comparing the therapeutic plan for fluid and vasoactive drug treatment between before and after knowing the EVLW value. RESULTS: We studied 42 patients. After knowing the EVLW, 52.4% (n = 22) of initial therapeutic plans were changed, modifying fluid therapy in all of these cases and vasoactive therapy in 22% of them. EVLW value was 13.91 +/- 5.62 in patients with change of therapeutic plan versus 10 +/- 4.52 in those with no change (p < 0.05). No differences were found in preload parameters as a function of change/no change. The most frequent decision change (n = 13) was to fluid reduction plus diuretic administration, and patients with this modification had significantly (p < 0.05) higher EVLW values compared with the remaining patients with a change in fluid therapy. Out of the 22 patients with a modified therapeutic decision, the therapy proved effective in 18 patients CONCLUSION: Quantification of EVLW in patients who can be considered euvolemic induces important modifications in fluid and vasoactive therapy. These changes generally resulted in a lower volume loading and a positive outcome for the patient.


Asunto(s)
Enfermedad Crítica/terapia , Agua Pulmonar Extravascular/fisiología , Fluidoterapia/métodos , Hipotensión/terapia , Hipoxia/terapia , Síndrome de Dificultad Respiratoria/terapia , Sepsis/terapia , Análisis de Varianza , Fármacos Cardiovasculares/uso terapéutico , Distribución de Chi-Cuadrado , Femenino , Hemodinámica , Humanos , Hipotensión/mortalidad , Hipotensión/fisiopatología , Hipoxia/mortalidad , Hipoxia/fisiopatología , Técnicas de Dilución del Indicador , Masculino , Estudios Prospectivos , Respiración Artificial , Síndrome de Dificultad Respiratoria/fisiopatología , Sepsis/fisiopatología
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