RESUMEN
Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of the capsules are explored with a synthetic/biopolymer hybrid capsule showing the best stability and small-molecule drug retention. The synthetic polymer is composed of pH-sensitive blocks (PDPA), low-binding blocks (PEG), and click-groups for postfunctionalization with targeting peptides specific to plaques.
Asunto(s)
Cápsulas/administración & dosificación , Sistemas de Liberación de Medicamentos/métodos , Placa Amiloide/tratamiento farmacológico , Polímeros/administración & dosificación , Animales , Cápsulas/química , Humanos , Ratones , Polímeros/químicaRESUMEN
Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.
