A Validation Study of the Work Need Satisfaction Scale for Korean Working Adults.

This study aimed to verify the reliability and validity of the Korean version of the Work Need Satisfaction Scale for working adults, based on the psychology of working theory. A total of 589 working adults in Korea responded to the online survey. Of these respondents, 339 were used for exploratory factor analysis and 250 for confirmatory factor analysis. In Stage 1, we translated all items into Korean, back-translated them into English, and then verified the accuracy of the translation. Exploratory factor analysis revealed the 5-factor structure of the Korean version of the Work Need Satisfaction Scale reflecting those of the original scale (survival needs, social contribution needs, autonomy, relatedness, and competence). The scale showed good internal consistency. In Stage 2, confirmatory factor analysis was conducted, and the results indicated that there were no significant differences between a correlational model, a higher-order model, and a higher-order self-determination needs model. Thus, we offered a higher-order self-determination needs model, which had better model fit and was consistent with the original scale and the psychology of working theoretical framework. In addition, convergent and discriminant validity were supported by correlation estimates of the Korean version of the Work Need Satisfaction Scale, and the concurrent validity showed that the Korean version of the Work Need Satisfaction Scale had a significant proportion of explained variance for outcomes. The findings support the conclusion that this study established strong internal consistency and validity for the Korean version of the Work Need Satisfaction Scale. Thus, the scale is unique and meaningful for measuring need satisfaction in work settings in Korea.

Application of the psychology of working theory with Korean emerging adults.

Psychology of Working Theory (PWT; Duffy, Blustein, Diemer, & Autin, 2016) is a recently developed framework aimed at documenting predictors and outcomes of decent work. To date, no studies have explored the applicability of the psychology of working perspective with emerging adults. The goal of the present study is to examine the predictor portion of PWT with a sample of Korean emerging adults from diverse economic backgrounds. Data were collected from a sample of 407 emerging adults attending a large junior college in Korea. Overall, most of the hypothesized direct paths were significant, with economic resources positively relating to both work volition and career adaptability and these positively relating to occupational engagement and future perceptions of securing decent work. Support for the hypothesized indirect effects was mixed. Overall, results suggest that the PWT is generally relevant and applicable to emerging adults when population-appropriate outcomes are included in the model and that the theory is supported in the Korean context. Based on the results, we also propose that interventions based on malleable psychological factors-the mediators in our study-may be targets when working with emerging adults experiencing economic constraints. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair.

Transcription factors are direct effectors of altered signaling pathways in cancer and frequently determine clinical outcomes in cancer patients. To uncover new transcription factors that would determine clinical outcomes in breast cancer, we systematically analyzed gene expression data from breast cancer patients. Our results revealed that Forkhead box protein M1 (FOXM1) is the top-ranked survival-associated transcription factor in patients with triple-negative breast cancer. Surprisingly, silencing FOXM1 expression led breast cancer cells to become more sensitive to doxorubicin (Dox). We found that FOXM1-dependent resistance to Dox is mediated by regulating DNA repair genes. We further demonstrated that NFκB1 interacts with FOXM1 in the presence of Dox to protect breast cancer cells from DNA damage. Finally, silencing FOXM1 expression in breast cancer cells in a mouse xenograft model significantly sensitized the cells to Dox. Our systematic approaches identified an unexpected role of FOXM1 in Dox resistance by regulating DNA repair genes, and our findings provide mechanistic insights into how FOXM1 mediates resistance to Dox and evidence that FOXM1 may be a promising therapeutic target for sensitizing breast cancer cells to Dox.