Quality Control of Heparin Injections: Comparison of Four Established Methods.

Heparin is an anticoagulant medication that is usually injected subcutaneously. The quality of a set of commercial heparin injections from different producers was examined by NMR, IR, UV-Vis spectroscopies and potentiometric multisensor system. The type of raw material regarding heparin animal origin and producer, heparin molecular weight and activity values were derived based on the non-targeted analysis of 1H NMR fingerprints. DOSY NMR spectroscopy was additionally used to study homogeneity and additives profile. UV-Vis and IR, being cheaper than NMR, combined with multivariate statistics were successfully applied to study excipients composition as well as semi-estimation of activity values. Potentiometric multisensor measurements were found to be an important additional source of information about inorganic composition of finished heparin formulations. All investigated instrumental techniques are useful for finished heparin injections and should be selected according to availability as well as the information and confidence required for a specific sample.

Distinguishing paracetamol formulations: Comparison of potentiometric "Electronic Tongue" with established analytical techniques.

Fast and inexpensive analytical tools for identification of the origin of pharmaceutical formulations are important to ensure consumers safety. This study explores the potential of potentiometric multisensor systems ("electronic tongues") in this type of application. 72 paracetamol samples purchased in different countries and produced by various companies were studied via infrared spectroscopy (IR), near infrared spectroscopy (NIR), nuclear magnetic resonance spectroscopy (NMR) and multisensor system (ET). A variety of chemometric tools was applied to explore and compare the information yielded by these methods. It was found that ET is capable of distinguishing paracetamol formulations from different producers. The chemical information derived from potentiometric sensor responses has something in common with that derived from NIR and IR; however, it is orthogonal to that from NMR. ET can be a valuable tool in express quality assessment of drugs.