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1.
Vaccine ; 42(9): 2135-2137, 2024 Apr 02.
Artículo en Inglés | MEDLINE | ID: mdl-38453618

RESUMEN

The COVID-19 pandemic has affected people of all ages worldwide. However, there is still no information on the vaccine effectiveness (VE) of inactivated COVID-19 vaccines in children aged less than 3 years old. This study highlighted that 2 doses of CoronaVac were effective in preventing COVID-19, with a VE of 83.1 %.


Asunto(s)
Vacunas contra la COVID-19 , COVID-19 , Vacunas de Productos Inactivados , Niño , Humanos , Preescolar , COVID-19/prevención & control , Hong Kong/epidemiología , Pandemias
2.
J Hazard Mater ; 87(1-3): 213-23, 2001 Oct 12.
Artículo en Inglés | MEDLINE | ID: mdl-11566411

RESUMEN

Chemical analysis of spent Co/Mo/gamma Al(2)O(3) catalyst revealed the presence of carbon, molybdenum, sulfur, vanadium and cobalt at levels of 16.0, 10.9, 7.3, 4.6 and 4.0 wt.%, respectively. It was found that calcination at 500 degrees C provides an effective solution for the removal of carbon and sulfur and this generates the oxide form of the heavy metals. The removal of these heavy metals can be achieved through a two-stage leaching process. During the first stage, in which concentrated ammonia is used and it has been found that this process can be successful in removing as much as 83% (w/v) Mo. In a second stage, it was found that using 10% (v/v) of sulfuric acid, it was possible to account for up to 77% (w/v) Co and 4% (w/v) Mo removal. Leaching test results indicated that the vanadium present in the heated spent catalyst was almost stabilized but the molybdenum and cobalt were not. The combination of two solid wastes, ladle furnace slag (LFS) and treated residue of spent catalyst, could be used for making a high value-added anorthite glass-ceramic materials. Further leaching tests showed that ceramic glass materials provided a very effective method of Co, Mo and V heavy metals stabilization resulting in a product with a possible commercial value.


Asunto(s)
Contaminación Ambiental/prevención & control , Metales Pesados/análisis , Silicatos de Aluminio/química , Catálisis , Cerámica/química , Vidrio/química , Metales Pesados/química , Petróleo , Eliminación de Residuos/métodos
3.
Biochem Biophys Res Commun ; 268(1): 133-5, 2000 Feb 05.
Artículo en Inglés | MEDLINE | ID: mdl-10652226

RESUMEN

A series of inhibitors of beta-amyloid formation have been developed based on the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein. A simple tripeptide aldehyde was found to be the most potent (IC(50) = 700 nM) in the series displaying an inhibitory profile which is different from reported inhibitors of beta-amyloid formation.


Asunto(s)
Péptidos beta-Amiloides/biosíntesis , Ácido Aspártico Endopeptidasas/antagonistas & inhibidores , Ácido Aspártico Endopeptidasas/metabolismo , Aldehídos/química , Aldehídos/farmacología , Secretasas de la Proteína Precursora del Amiloide , Péptidos beta-Amiloides/química , Animales , Sitios de Unión , Células COS , Línea Celular , Diseño de Fármacos , Endopeptidasas , Inhibidores Enzimáticos/química , Inhibidores Enzimáticos/farmacología , Humanos , Oligopéptidos/química , Oligopéptidos/farmacología , Procesamiento Proteico-Postraduccional/efectos de los fármacos , Relación Estructura-Actividad
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