RESUMEN
Sclerosing rhabdomyosarcoma (RMS) is a rare subtype of RMS with unique prominent stromal hyalinization and a pseudovascular architecture. It overlaps morphologically with spindle cell RMS and poses both diagnostic and therapeutic challenges because of its rarity and aggressive clinical course. In this article, we report a case of sclerosing RMS arising from a prior craniotomy site, which demonstrated both sclerosing and spindle cell components. A literature review of RMS with sclerosing morphology identified 122 cases. Our review documents the following: sclerosing RMS occurs in both childhood and adult populations, has a predilection for the head and neck areas, and has a worse prognosis in adults. Sclerosing RMS harbors a high frequency of MYOD1 mutations, conferring a poor clinical outcome. Sclerosing RMS and spindle RMS likely represent a morphologic spectrum of one entity.
Asunto(s)
Craneotomía/efectos adversos , Neoplasias de Cabeza y Cuello/patología , Neoplasias de los Músculos/patología , Rabdomiosarcoma/patología , Tejido Subcutáneo/patología , Aneurisma Roto/etiología , Aneurisma Roto/cirugía , Biopsia , Encéfalo/diagnóstico por imagen , Encéfalo/patología , Quimioradioterapia Adyuvante , Diagnóstico Diferencial , Neoplasias de Cabeza y Cuello/diagnóstico por imagen , Neoplasias de Cabeza y Cuello/etiología , Neoplasias de Cabeza y Cuello/terapia , Humanos , Aneurisma Intracraneal/complicaciones , Masculino , Persona de Mediana Edad , Neoplasias de los Músculos/diagnóstico por imagen , Neoplasias de los Músculos/etiología , Neoplasias de los Músculos/terapia , Rabdomiosarcoma/diagnóstico por imagen , Rabdomiosarcoma/etiología , Rabdomiosarcoma/terapia , Cuero Cabelludo , Esclerosis , Tejido Subcutáneo/diagnóstico por imagen , Tomografía Computarizada por Rayos XRESUMEN
We report the case of a 62-year-old woman who underwent laparoscopic hysterectomy, bilateral salpingo-oophorectomy, and lymph node dissection for endometrial endometrioid carcinoma FIGO grade 1. Cytologic examination of the pelvic washing specimen showed an acellular matrix with frayed edges and cracking artifact. Upon investigation, it became apparent that this could represent hemostatic matrix FlosealR that had been used intraoperatively at the lymphadenectomy site. Laboratory replication of the cytologic findings with a FlosealR sample confirmed it. This is the first reported case of FlosealR in pelvic washing cytology and represents a potential diagnostic pitfall. Diagn. Cytopathol. 2016;44:1117-1119. © 2016 Wiley Periodicals, Inc.
