An Evaluation Approach of Community Emergency Management Ability Based on Cone-ANP.

In order to improve the emergency management ability of urban communities in response to emergencies and reduce the losses caused by emergencies, based on the method of Cone-Analytic Network Process (Cone-ANP), a whole-process community emergency management ability evaluation method was proposed. Using around 25 evaluation indexes from six dimensions, namely infrastructure resilience, community organization resilience, risk management, emergency material support, emergency force building, and emergency literacy, this method established the dominant relationship of each index by the analysis of the cone network structure. It determined the community safety culture construction as the cone-top element, and obtained the limit weight vector of all the evaluation indexes by expert evaluation. The membership degree of each index was calculated to quantify the evaluation results of community emergency management ability. The results could provide a guidance and reference basis for community emergency management.

Study on the Evaluation of Emergency Management Capacity of Resilient Communities by the AHP-TOPSIS Method.

Community emergency management is directly related to the safety of people's lives and properties and is concerned with economic development and social stability. This paper established an evaluation model of community emergency management capacity from the perspective of resilience based on hierarchical analysis (AHP) and distance between superior and inferior solutions (TOPSIS). In terms of infrastructure resilience, community organizational resilience, risk, and hidden danger management, emergency material security, emergency force construction, emergency literacy, and the evaluation index system of resilient community emergency management capacity were improved. By the AHP method, the weights of all indexes were determined scientifically. Combined with the TOPSIS method, the fit of the evaluated object which between the positive and negative ideal solution was calculated to determine the optimal evaluation among multiple experts. According to the validated assessment, the low-scoring indicators were analyzed to make practical suggestions for improvement. The results provide new theoretical methods and technical support for the assessment of community emergency response capacity, which also provides reference for the assessment of emergency response capacity in other fields.

The genetic admixture in Tibetan-Yi Corridor.

OBJECTIVES: The Tibetan-Yi Corridor located on the eastern edge of Tibetan Plateau is suggested to be the key region for the origin and diversification of Tibeto-Burman speaking populations and the main route of the peopling of the Plateau. However, the genetic history of the populations in the Corridor is far from clear due to limited sampling in the northern part of the Corridor. MATERIALS AND METHODS: We collected blood samples from 10 Tibetan and 10 Han Chinese individuals from Gansu province and genotyped about 600,000 genome-wide single nucleotide polymorphisms (SNPs). RESULTS: Our data revealed that the populations in the Corridor are all admixed on a genetic cline of deriving ancestry from Tibetans on the Plateau and surrounding lowland East Asians. The Tibetan and Han Chinese groups in the north of the Plateau show significant evidence of low-level West Eurasian admixture that could be probably traced back to 600∼900 years ago. DISCUSSION: We conclude that there have been huge population migrations from surrounding lowland onto the Tibetan Plateau via the Tibetan-Yi Corridor since the initial formation of Tibetans probably in Neolithic Time, which leads to the current genetic structure of Tibeto-Burman speaking populations.

Effect of microRNA-101 on apoptosis of rabbit condylar cartilage cells by inhibiting target gene SOX9.

OBJECTIVE: To explore the effect of microRNA-101 on apoptosis of condylar cartilage cells and the specific mechanism of molecular biology. METHODS: IL-1 was used to stimulate and establish the model of apoptosis of condylar cartilage cells. The expression change of miR-101 in control group was compared with that in IL-1 stimulation group by qRT-PCR. Overexpression and down-regulation models of miR-101 were established by transfecting Mimics and Inhibitor and verified by qRT-PCR. Flow cytometry was used to detect the effect of miR-101 overexpression and down-regulation on apoptosis. Target gene of miR-101 was analyzed and calculated through bioinformatics. Western blot and Luciferase report assay were used to detect whether SOX9 could become the target gene of miR-101. RESULTS: qRT-PCR results showed that IL-1 stimulation could cause the increase of miR-101 expression. After the transfection of rabbit condylar cartilage cells by Mimics and Inhibitor, qRT-PCR results confirmed the significant effect of miR-101 overexpression and down-regulation. It was confirmed by flow cytometry that overexpression of miR-101 could promote the apoptosis of condylar cartilage cells, and down-regulation of miR-101 could reduce the apoptosis. It was confirmed by Western blot and Luciferase report assay that SOX9 was the target gene of miR-101, and miR-101 inhibited SOX9 expression through complementary pairing with 3'UTR of SOX9 mRNA. CONCLUSIONS: miR-101 can promote the apoptosis of condylar cartilage cells through inhibiting the protein level of target gene SOX9.