RESUMEN
Acerola cherry is a world famous fruit which contains abundant antioxidants such as vitamin C, anthocyanins, flavonoids, and phenolics. However, studies concerning bioactivity components from aerial parts of acerola (Malpighia emarginata) are scarce. In view of this, we have examined the constituents of aerial parts of acerola, and three new tetranorditerpenes acerolanins A-C (1-3) with a rare 2H-benz[e]inden-2-one substructure were isolated. Their structures were determined on the basis of spectral studies and acerolanin C was confirmed by X-ray crystallographic analysis. Furthermore, three new compounds have been studied for their cytotoxic activity.
Asunto(s)
Antioxidantes/química , Diterpenos/química , Malpighiaceae/química , Extractos Vegetales/química , Antocianinas , Antioxidantes/aislamiento & purificación , Diterpenos/aislamiento & purificación , Aromatizantes/química , Frutas/química , Componentes Aéreos de las Plantas/químicaRESUMEN
Three novel norfriedelanes, A-C (1-3), were isolated from the branches and roots of Malpighia emarginata . Their structures and absolute configurations were determined by 1D and 2D NMR techniques and X-ray crystallographic analysis. Norfriedelin A (possessing an α-oxo-ß-lactone group) and norfriedelin B (with a keto-lactone group) showed acetylcholinesterase inhibitory effects with the IC50 values of 10.3 and 28.7 µM, respectively.
Asunto(s)
Inhibidores de la Colinesterasa/aislamiento & purificación , Inhibidores de la Colinesterasa/farmacología , Malpighiaceae/química , Triterpenos/aislamiento & purificación , Triterpenos/farmacología , Inhibidores de la Colinesterasa/química , Cristalografía por Rayos X , Concentración 50 Inhibidora , Conformación Molecular , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Triterpenos/químicaRESUMEN
Myelin contains many axonal outgrowth inhibitory components which contribute to regeneration failure after neuronal injury in the mammalian central nervous system (CNS). In an attempt to develop small molecular agents to promote axonal outgrowth, we screened a compound library purified from traditional Chinese herbs, and found a small molecular compound polygalasaponin G (PS-G), extracted from Polygala japonica, which has a potent neurotrophic activity on PC12 cells and cultured cortical neurons. We reported, to our knowledge for the first time, that PS-G could promote neurite outgrowth of neurons cultured on the myelin substrates and inhibit the activation of RhoA. Thus, our results could represent a therapeutic approach to improve axon regeneration after CNS injuries.
Asunto(s)
Vaina de Mielina/fisiología , Neuritas/efectos de los fármacos , Neuronas/citología , Polygala/química , Saponinas/farmacología , Animales , Animales Recién Nacidos , Células Cultivadas , Cerebelo/citología , Cerebelo/fisiología , Relación Dosis-Respuesta a Droga , Etiquetado Corte-Fin in Situ/métodos , Proteínas de la Mielina/farmacología , Factor de Crecimiento Nervioso/farmacología , Neurogénesis/efectos de los fármacos , Neurogénesis/fisiología , Proteínas Nogo , Células PC12 , Ratas , Saponinas/química , Proteína de Unión al GTP rhoA/metabolismoRESUMEN
The antitumor activities of the crude extracts of Daphne tangutica Maxim. (Thymelaeaceae) and some compounds were investigated in vivo for the first time. The eight tested samples exhibited inhibition in mice transplanted with sarcoma S180. Of the eight samples, two samples DTE-2 (mixture of daphnodorin E and daphnodorin F) and DTE-3 (syringin) were noted to have the most marked antitumor activity.
Asunto(s)
Daphne/química , Extractos Vegetales/uso terapéutico , Raíces de Plantas/química , Sarcoma 180/tratamiento farmacológico , Animales , Cumarinas/aislamiento & purificación , Glucósidos/aislamiento & purificación , Fenilpropionatos/aislamiento & purificaciónRESUMEN
A new bisxanthone, named jacarelhyperols D (1), was isolated from the whole plant of Hypericum japonicum. Its chemical structure was elucidated as 6-[1',5',6'-trihydroxy-2''-(alpha-hydroxy-alpha-methyl)ethyl-3'',4''-dihydrofuran (2'',3'',3',4') xanthone-3''-oxyl]-1,3,5-trihydroxy-xanthone on the basis of spectroscopic analysis.
Asunto(s)
Hypericum , Fitoterapia , Xantonas/química , Humanos , Espectroscopía de Resonancia Magnética , Estructuras de las PlantasRESUMEN
Five new triterpenoid saponins, polygalasaponins E (1), F (2), G (3), H (4), and J (5), along with eight known ones (6-13), were isolated from the aerial parts of Polygala japonica. Their structures were established by chemical and spectroscopic means. Forced swimming tests on mice showed that saponins 1 and 4 significantly reduce the immobility status by 58.1% and 51.3% at a dosage of 100 mg/kg administrated orally once daily for 5 days, respectively.
Asunto(s)
Medicamentos Herbarios Chinos , Actividad Motora/fisiología , Plantas Medicinales/química , Polygala/química , Saponinas , Triterpenos , Animales , Trastorno Depresivo , Modelos Animales de Enfermedad , Medicamentos Herbarios Chinos/administración & dosificación , Medicamentos Herbarios Chinos/química , Medicamentos Herbarios Chinos/aislamiento & purificación , Medicamentos Herbarios Chinos/farmacología , Masculino , Medicina Tradicional China , Ratones , Ratones Endogámicos ICR , Estructura Molecular , Actividad Motora/efectos de los fármacos , Saponinas/administración & dosificación , Saponinas/química , Saponinas/aislamiento & purificación , Saponinas/farmacología , Natación , Triterpenos/administración & dosificación , Triterpenos/química , Triterpenos/aislamiento & purificación , Triterpenos/farmacologíaRESUMEN
Six new lignans (2-7) were isolated from the bark of Larix olgensis var. koreana, and their structures were determined on the basis of their spectroscopic data. Seven known lignans were also obtained and identified as (+)-lariciresinol 9'-p-coumarate (1), (+)-lariciresinol, (-)-secoisolariciresinol, (+)-isolariciresinol, vladinol D, sesquipinsapol B, and ehletianol C. Compound 1 showed weak inhibition against K562, SHG44, HCT-8, A549, and PC-3M tumor cells with IC50 values of 2.9, 21.4, 32.9, 33.8, and 28.0 microg/mL, respectively.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Medicamentos Herbarios Chinos/aislamiento & purificación , Furanos/aislamiento & purificación , Larix/química , Lignanos/aislamiento & purificación , Plantas Medicinales/química , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Butileno Glicoles , Ensayos de Selección de Medicamentos Antitumorales , Medicamentos Herbarios Chinos/química , Medicamentos Herbarios Chinos/farmacología , Furanos/química , Furanos/farmacología , Concentración 50 Inhibidora , Lignanos/química , Lignanos/farmacología , Estructura Molecular , Estereoisomerismo , Células Tumorales CultivadasRESUMEN
OBJECTIVE: To study the chemical constituents from Daphne odora var. atrocaulis. METHOD: The chemical constituents were isolated and repeatedly purified by silica gel column chromatography and the structures were elucidated by the NMR spectra and physicochemical properties. RESULT: Sixteen compounds were obtained and nine of them were identified as beta-sitosterol, 4-hydroxy ethylbenzoate, (2E),-2-propenoic acid,3-(3,4-dihydroxyphenyl)-decosylester, genkwanin, 2,4-dihydroxypyrimidine, daphnetin, daphnoretin, 5,7,4'-trihydroxyflavone-3ol, daucosterol. CONCLUSION: Seven compounds were obtained from D. odora var. atrocaulis. for the first time.
Asunto(s)
Cumarinas/aislamiento & purificación , Daphne/química , Flavonas/aislamiento & purificación , Plantas Medicinales/química , Umbeliferonas/aislamiento & purificación , Cumarinas/química , Flavonas/química , Raíces de Plantas/química , Umbeliferonas/químicaRESUMEN
OBJECTIVE: To study the chemical constituents in bark of Larix olgensis var. koreana. METHOD: The compounds were isolated with silica gel column chromatography and their structures were elucidated on the basis of spectral analysis (IR, EI-MS, 1H-NMR, 13C-NMR). RESULT: Eight compounds were isolated and identified as isopimaric acid (I), beta-sitosterol (II), 24R,5alpha-stigmast-3,6-dione (III), larixol (IV), ferulic acid (V), lariciresinol (VI), secroisolariciresinol (VII) and isolariciresinol (VIII). CONCLUSION: All the compounds were isolated from this plant for the first time.
Asunto(s)
Ácidos Carboxílicos/aislamiento & purificación , Furanos/aislamiento & purificación , Larix/química , Lignanos/aislamiento & purificación , Fenantrenos/aislamiento & purificación , Plantas Medicinales/química , Ácidos Carboxílicos/química , Furanos/química , Lignanos/química , Fenantrenos/química , Corteza de la Planta/química , Sitoesteroles/química , Sitoesteroles/aislamiento & purificaciónRESUMEN
From the roots of Patrinia scabra two new iridoids, 3-methylbutyric acid 7-hydroxy-7-hydroxymethyl-4-(3-methyl-butyryloxymethyl)-6-oxo-1,6,7,7a-tetrahydrocyclopenta[c]pyran-1-yl ester (1) and 6-hydroxy-7-methylhexahydrocyclopenta[c]pyran-3-one (2) have been isolated. Their structures were determined by means of NMR spectra and X-ray crystallographic analysis.
Asunto(s)
Iridoides/química , Patrinia/química , Iridoides/aislamiento & purificación , Conformación Molecular , Estructura MolecularRESUMEN
Nine new triterpenoid saponins were isolated from the bulbs of Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae): 7beta,18,20,26-tetrahydroxy-(20S)-dammar-24 E-en-3-O-alpha-L-(3-acetyl)arabinopyranosyl-(1-->2)-beta-D-glucopyranoside, 7beta,18,20,26-tetrahydroxy-(20S)-dammar-24E-en-3-O-alpha-L-(4-acetyl)arabinopyranosyl-(1-->2)-beta-D-glucopyranoside, 7beta,18,20,26-tetrahydroxy-(20S)-dammar-24E-en-3-O-alpha-L-arabinopyranosyl-(1-->2)-beta-D-(6-acetyl)glucopyranoside, 7beta,20,26-trihydroxy-(20S)-dammar-24E-en-3-O-alpha-L-arabinopyranosyl-(1-->2)-beta-D-glucopyranoside, 7beta,20,26-trihydroxy-(20S)-dammar-24E-en-3-O-alpha-L-(3-acetyl)arabinopyranosyl-(1-->2)-beta-D-glucopyranoside, 7beta,20,26-trihydroxy-(20S)-dammar-24E-en-3-O-alpha-L-(4-acetyl)arabinopyranosyl-(1-->2)-beta-D-glucopyranoside, 7beta,20,26-trihydroxy-8-formyl-(20S)-dammar-24E-en-3-O-alpha-L-(3-acetyl)arabinopyranosyl-(1-->2)-beta-D-glucopyranoside, 7beta,20,26-trihydroxy-8-formyl-(20S)-dammar-24E-en-3- O-alpha-L-(4-acetyl)arabinopyranosyl-(1-->2)-beta-D-glucopyranoside and 6'-O-palmitoyltubeimoside I. In addition, four known triterpenoid saponins: tubeimoside I, tubeimoside II, tubeimoside III and tubeimoside IV were isolated. The structures of the above compounds were elucidated based on spectroscopic studies, and the configuration of C-20 of tubeimoside IV was revised as S rather than R as reported in previous literature. The compounds were tested for their antiviral activity
Asunto(s)
Antivirales/farmacología , Cucurbitaceae , Herpesvirus Humano 1/efectos de los fármacos , Fitoterapia , Extractos Vegetales/farmacología , Saponinas/farmacología , Triterpenos/farmacología , Aciclovir/farmacología , Animales , Antivirales/administración & dosificación , Antivirales/química , Antivirales/uso terapéutico , Chlorocebus aethiops , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/administración & dosificación , Extractos Vegetales/química , Extractos Vegetales/uso terapéutico , Saponinas/administración & dosificación , Saponinas/química , Saponinas/uso terapéutico , Triterpenos/administración & dosificación , Triterpenos/química , Triterpenos/uso terapéutico , Células Vero/efectos de los fármacosRESUMEN
OBJECTIVE: To investigate the chemical constituents of the bulbs of Bolbostemma panicultum. METHOD: The compounds were isolated by column chromatography on silica gel, C18, Sephadex LH-20 separately and their structures were elucidated by chemical and spectroscopic technologies. RESULT: Eight compounds were isolated and identified as maltol(I), emodin(II), cucurbitacin B(III), cucurbitacin E(IV), stigmasta-7, 22, 25-triene-3-ol(V), stigmasta-7, 22, 25-triene-3-nonadecanoic acid ester(VI), stigmasta-7, 22, 25-triene-3-O-beta-D-glucopyranoside(VII), stigmasta-7, 22, 25-triene-3-O-beta-D-(6'-palmitoyl) glucopyranoside(VIII). CONCLUSION: I-VIII were obtained from this plant for the first time; VI and VIII are new compounds.
Asunto(s)
Cucurbitaceae/química , Plantas Medicinales/química , Saponinas/aislamiento & purificación , Estigmasterol/análogos & derivados , Estigmasterol/aislamiento & purificación , Emodina/química , Emodina/aislamiento & purificación , Estructura Molecular , Raíces de Plantas/química , Saponinas/química , Estigmasterol/química , Triterpenos/química , Triterpenos/aislamiento & purificaciónRESUMEN
OBJECTIVE: To analyse the effects of buyang huanwu decoction (BYHWT) on differentially expressed genes during cerebral ischemia/reperfusion in rats with DNA microarray. METHOD: cDNA microarray chips containing 512 cDNAs were made by Biostar Genechip Inc. Sprague-Dawley rats were subjected to 2 h of middle cerebral artery occlusion (MCAO) with an filament. Saline or BYHWT was given p.o. after onset of cerebral ischemia and brains were removed after 24 h of recirculation for mRNAs isolation. A differential measurment of mRNAs from post-ischemic and BYHWT treated animals was performed with microarray. RESULT: Up-and down-regulated genes were 69 and 80 in ischemic group. Up-and down-regulated genes were 25 and 6 in BYHWT treated group. CONCLUSION: BYHWT regulates the differential expression genes after focal brain ischemia/reperfusion in rats, due to its mechanism of protecting cerebral ischemia/reperfusion injury.
Asunto(s)
Isquemia Encefálica/genética , Medicamentos Herbarios Chinos/farmacología , Perfilación de la Expresión Génica , Fármacos Neuroprotectores/farmacología , Daño por Reperfusión/genética , Animales , Isquemia Encefálica/complicaciones , Masculino , Análisis de Secuencia por Matrices de Oligonucleótidos , Ratas , Ratas Sprague-Dawley , Daño por Reperfusión/etiologíaRESUMEN
AIM: To study the lignans from Patrinia scabra Bunge. METHODS: The constituents were separated and purified by column chromatography with silical gel, RP-silical gel and Sephadex LH-20. Their structures were identified on the basis of spectral data (IR, MS, 1HNMR, 13CNMR, HMQC and HMBC). RESULTS AND CONCLUSION: A new lignan was obtained and its structure was elucidated as 4-[1-ethoxyl-1-(4-hydroxy-3-methoxy)benzyl]methyl- 2-(4-hydroxy-3-methoxy)benzyl-3-hydroxymethyl-tetrahydro-furan (2), along with three known lignans, lariciresinol (1), isolariciresinol (3) and nortracheloside (4).
Asunto(s)
Furanos/aislamiento & purificación , Guayacol/aislamiento & purificación , Patrinia/química , Furanos/química , Guayacol/análogos & derivados , Guayacol/química , Lignanos/química , Lignanos/aislamiento & purificación , Lignina/química , Lignina/aislamiento & purificación , Estructura Molecular , Naftoles/química , Naftoles/aislamiento & purificación , Raíces de Plantas/química , Plantas Medicinales/químicaRESUMEN
Three pyrrole alkaloids were isolated from Bolbostemma paniculatum. Their structures were elucidated as 4-(2-formyl-5-methoxymethylpyrrol-1-yl)butyric acid methyl ester (1), 2-(2-formyl-5-methoxymethylpyrrol-1-yl)-3-phenylpropionic acid methyl ester (2) and alpha-methyl pyrrole ketone (3) by spectroscopic techniques. Among them, 1 and 2 are new compounds.