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1.
Front Vet Sci ; 11: 1435827, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39044742

RESUMEN

Canine circovirus (CanineCV) is a recently identified member of the Circoviridae family. Since its discovery in 2011, CanineCV has been detected in different countries worldwide, infecting both domestic and wild canids. The virus is potentially associated with gastrointestinal and respiratory illnesses. In 2016, CanineCV was reported in the southwestern region of Guangxi, China. However, its prevalence in other provinces in the Southwest region remained unknown. This study collected a total of 208 serum samples from domestic dogs in Sichuan, China in 2022 to investigate the prevalence of CanineCV. Among these samples, 26 tested positive for CanineCV, resulting in a positivity rate of 12.5%. Additionally, 12 strains were sequenced, 9 of which had a sequence length of 2,063 nucleotides (nt), 2 of the other threes had a length of 2,062 nts and another was 2,064 nt. Notably, a frameshift mutation was identified, resulting in a truncated ORF1 and the occurrence of a novel sequence comprised of 13 amino acids at the end of the replicate protein (Rep). This mutation could affect the replication cycle of the virus. Phylogenetic and evolutionary analyses revealed that the isolates belonged to the CanineCV-3 genotype and were prevalent in the Southeast and the Southwest regions of China, as well as in the neighboring countries alongside other strains of the same genotype. Collectively, this epidemiological investigation widens our understanding of the genetic diversity of CanineCV in Southwest China and provides insights into viral evolution.

2.
Nutr Neurosci ; 26(10): 997-1010, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-36039913

RESUMEN

OBJECTIVE: Depression is one of the most common complications in patients with diabetes. Our previous study demonstrated puerarin, a dietary isoflavone, improved glucose homeostasis and ß-cell regeneration in high-fat diet (HFD)-induced diabetic mice. Here, we aim to evaluate the potential effect of puerarin on diabetes-induced depression. METHODS: The co-occurrence of diabetes and depression with related biochemical alterations were confirmed in HFD mice and db/db mice, respectively using behavioral analysis, ELISA and western blotting assay. Furthermore, impacts of puerarin on depression-related symptoms and pathological changes were investigated in HFD mice. RESULTS: The results showed that puerarin effectively alleviated the depression-like behaviors of HFD mice, down-regulated serum levels of corticosterone and IL-1ß, while up-regulated the content of 5-hydroxytryptamine. Simultaneously, puerarin increased the number of hippocampal neurons in HFD mice, and suppressed the apoptosis of neurons to protect the hippocampal neuroplasticity. GLP-1R expression in hippocampus of HFD mice was enhanced by puerarin, which subsequently activated AMPK, CREB and BDNF/TrkB signaling to improve neuroplasticity. Importantly, our data indicated that puerarin had an advantage over fluoxetine or metformin in treating diabetes-induced depression. CONCLUSION: Taken together, puerarin exerts anti-depressant-like effects on HFD diabetic mice, specifically by improving hippocampal neuroplasticity via GLP-1R/BDNF/TrkB signaling. Puerarin as a dietary supplement might be a potential candidate in intervention of diabetes with comorbid depression.


Asunto(s)
Diabetes Mellitus Experimental , Isoflavonas , Ratones , Animales , Factor Neurotrófico Derivado del Encéfalo/metabolismo , Diabetes Mellitus Experimental/complicaciones , Diabetes Mellitus Experimental/tratamiento farmacológico , Diabetes Mellitus Experimental/metabolismo , Dieta Alta en Grasa/efectos adversos , Depresión/etiología , Depresión/inducido químicamente , Isoflavonas/farmacología , Hipocampo/metabolismo
3.
Artículo en Inglés | MEDLINE | ID: mdl-35574831

RESUMEN

Sleep quality plays an essential role in human health and has become an index for assessing physical health. Self-powered, sensitive, noninvasive, comfortable, and low-cost sleep monitoring sensors for monitoring sleep behavior are still in high demand. Here, a pressure-sensitive, noninvasive, and comfortable smart pillow is developed based on a flexible and breathable triboelectric nanogenerator (FB-TENG) sensor array, which can monitor head movement in real time during sleep. The FB-TENG is based on flexible and breathable porous poly(dimethylsiloxane) (PDMS) with a fluorinated ethylene propylene (FEP) powder and exhibits pressure sensitivity and durability. The electrical output of the FB-TENG is further optimized by modifying the porous structure and the FEP powder. Combining the FB-TENG and the flexible printed circuit (FPC), a self-powered pressure sensor array is fabricated to realize touch sensing and motion track monitoring. The smart pillow is formed by laying the self-powered pressure sensor array on an ordinary pillow to realize real-time monitoring of the head position in a static state and head movement trajectory in a dynamic state during sleep. Additionally, the smart pillow also has an early warning function for falling out of bed. This work not only provides a viable sensing device for sleep monitoring but also could be extended to real-time monitoring of some diseases, such as brain diseases and cervical spondylosis, in the future. It is expected to introduce a practical strategy in the real-time mobile healthcare field for disease management.

4.
Sci Adv ; 7(39): eabj0349, 2021 Sep 24.
Artículo en Inglés | MEDLINE | ID: mdl-34559569

RESUMEN

Contact electrification (CE) (or triboelectrification) is the phenomena where charges are produced through physical contact between two materials. Here we report the atomic featured photon emission spectra during CE between two solid materials. Photon emission provides the evidence that electron transfer takes place at the interface from an atom in one material to another atom in the other material during CE. This process is the contact electrification induced interface photon emission spectroscopy (CEIIPES). It naturally paves a way to a spectroscopy corresponding to the CE at an interface, which might impact our understanding of the interaction between solids, liquids, and gases. The physics presented here could be expanded to Auger electron excitation, x-ray emission, and electron emission in CE for general cases, which remain to be explored. This could lead to a general field that may be termed as contact electrification induced interface spectroscopy (CEIIS).

5.
Endocrine ; 74(3): 571-581, 2021 12.
Artículo en Inglés | MEDLINE | ID: mdl-34255273

RESUMEN

PURPOSE: Sodium-glucose transporters (SGLTs) are important targets for therapeutic intervention of type 2 diabetes. This study aims to evaluate the physiological influences of diabetes mellitus and the potential impacts of metformin and fluoxetine on SGLTs expressions. METHODS: Alterations of SGLT1 and SGLT2 were measured in organs involved in glucose homeostasis (kidney, intestine, liver and pancreas) of streptozotocin (STZ) and high-fat diet (HFD) induced diabetic mice by western blotting and real-time PCR (RT-PCR) respectively. RESULTS: In kidney, duodenal segments of intestine, liver, and pancreas of HFD diabetic mice, expressions of SGLT2 were all elevated compared to control mice. The level of SGLT1 was significantly increased in intestine, but was decreased in pancreas. SGLT1 expression in kidney was unaffected, and SGLT1 was undetectable in hepatocytes. Similar results were obtained in STZ diabetic mice. More importantly, here we noticed metformin decreased levels of SGLT2 in kidney, intestine, and pancreas of HFD mice markedly. Expressions of SGLT1 in intestine and pancreas were reduced by metformin as well. In contrast, fluoxetine increased abundances of SGLT2 and SGLT1 in kidney of HFD mice, but decreased SGLT1 expression in intestine. CONCLUSIONS: The present study provided evidence that expressions of SGLT1 and SGLT2 were significantly modulated by diabetes mellitus as well as by metformin and fluoxetine, which indicated the efficacy of SGLT2 inhibitors might be impacted by these factors.


Asunto(s)
Diabetes Mellitus Experimental , Diabetes Mellitus Tipo 2 , Proteínas de Transporte de Sodio-Glucosa , Animales , Diabetes Mellitus Experimental/tratamiento farmacológico , Diabetes Mellitus Tipo 2/tratamiento farmacológico , Glucosa , Hipoglucemiantes/farmacología , Hipoglucemiantes/uso terapéutico , Ratones , Transportador 1 de Sodio-Glucosa , Transportador 2 de Sodio-Glucosa
6.
Clin Interv Aging ; 14: 1119-1129, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31354254

RESUMEN

Objective: This study aims to analyze the prevalence of dyslipidemia and identify the cardiovascular disease (CVD) risk stratification among older adults living in Quanzhou, China's southeast coastal region, where the ancient Maritime Silk Road starts. Methods: A population-based cross-sectional survey of 2,018 adults was conducted in 60-98-year-old residents in Quanzhou from September 2016 to March 2018 using multistage stratified cluster random sampling. The 10-year CVD risk was also estimated by applying the Chinese model recommended by the Chinese Guidelines for Prevention of Cardiovascular Diseases. Results: The overall prevalence of dyslipidemia among older adults was 56.8%. The prevalence of high total cholesterol (TC), high low-density lipoprotein cholesterol (LDL-C), low high-density lipoprotein cholesterol (HDL-C) and high triglyceride (TG) were 8.4%, 13.9%, 23.1% and 11.4%, respectively. The mean levels of TC, LDL-C, HDL-C and TG were 5.12±1.18, 3.37±0.81, 1.03±0.27 and 1.65±0.76 mmol/L, respectively. Older adults had low risk, moderate risk and high risk for CVD, which were 49.7%, 36.8% and 13.5%, respectively. Age, body mass index and abdominal obesity were significantly associated with the risk of increasing LDL-C levels and were positively correlated to CVD risk. Conclusion: The prevalence of high TC, high LDL-C, low HDL-C and high TG was relatively low among older adults in Quanzhou, but their lipid levels were high. Approximately half of the elderly adults had moderate or high CVD risk. The personalized primary prevention and control of CVD are recommended for elderly people to identify high-risk individuals.


Asunto(s)
Enfermedades Cardiovasculares/epidemiología , Dislipidemias/epidemiología , Factores de Edad , Anciano , Anciano de 80 o más Años , Pueblo Asiatico , Índice de Masa Corporal , China/epidemiología , Estudios Transversales , Femenino , Humanos , Lípidos/sangre , Masculino , Persona de Mediana Edad , Obesidad Abdominal , Prevalencia , Prevención Primaria , Factores de Riesgo
7.
J Tradit Chin Med ; 33(3): 287-93, 2013 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-24024320

RESUMEN

OBJECTIVE: To explore the effect of electroacupuncture and Chinese kidney-nourishing medicine on insulin (INS), adiponectin (APN), leptin (LEP), and glucolipid metabolism of obese patients with polycystic ovary syndrome (PCOS). METHODS: Sixty-seven obese PCOS patients were randomly divided into two groups. Thirty-three patients in the acupuncture-medicine group were treated three times a week with electroacupuncture at the Tianshu (ST 25), Zhongwan (CV 12), Qi-hai (CV 6), Sanyinjiao (SP 6), Geshu (BL 17), and Ciliao (BL 32) acupoints. They also took the Chinese drug, Tiankui capsule, for 3 months as a course of treatment. Point-taking and treatment in the electroacupuncture group of 34 patients was the same as those in the acupuncture-medicine group. We observed and compared the changes in the obesity-related indexes of body weight (BW), body mass index (BMI), and waist-hip ratio (WHR), as well as fasting plasma glucose (FPG), fasting insulin (FINS), APN, and LEP. RESULTS: BW, BMI, WHR, and FINS decreased and insulin sensitivity index (ISI) and APN were higher in the acupuncture-medicine group than in the electroacupuncture group (P < 0.01). There was no obvious difference in LEP between the two groups (P > 0.05). CONCLUSION: Acupuncture combined with medicine is better than just electroacupuncture for obese PCOS patients by improving obesity-related indexes, insulin sensitivity, and APN level. This indicates that acupuncture-medicine therapy is worth clinical popularization.


Asunto(s)
Medicamentos Herbarios Chinos/administración & dosificación , Electroacupuntura , Obesidad/terapia , Síndrome del Ovario Poliquístico/terapia , Adiponectina/metabolismo , Adolescente , Adulto , Peso Corporal , Terapia Combinada , Femenino , Glucosa/metabolismo , Humanos , Resistencia a la Insulina , Leptina/metabolismo , Obesidad/tratamiento farmacológico , Obesidad/metabolismo , Obesidad/fisiopatología , Síndrome del Ovario Poliquístico/tratamiento farmacológico , Síndrome del Ovario Poliquístico/metabolismo , Síndrome del Ovario Poliquístico/fisiopatología , Relación Cintura-Cadera , Adulto Joven
8.
Zhen Ci Yan Jiu ; 37(1): 72-6, 2012 Feb.
Artículo en Chino | MEDLINE | ID: mdl-22574574

RESUMEN

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women of reproductive age, and the obesity and insulin resistance are considered to be the key link in the pathophysiological process of PCOS of obesity type. Adiponectin, a protein hormone, is closely related to insulin resistance and obesity, which has been being researched extensively in recent years. The authors of the present article review the pathogenesis of PCOS of obesity type from the relationship between adiponectin and obesity, and between adiponectin and insulin resistance, separately. In particular, the authors review studies on the underlying mechanism of acupuncture and moxibustion interventions in regulating adiponectin level briefly. The authors think of that acupuncture and moxibustion interventions induced increase of adiponectin level is possibly to improve insulin resistance in obesity and/or PCOS patients, hoping to provide a new target for clinical treatment of PCOS.


Asunto(s)
Terapia por Acupuntura , Adiponectina/genética , Obesidad/genética , Obesidad/terapia , Síndrome del Ovario Poliquístico/genética , Síndrome del Ovario Poliquístico/terapia , Adiponectina/metabolismo , Femenino , Regulación de la Expresión Génica , Humanos , Moxibustión , Obesidad/metabolismo , Síndrome del Ovario Poliquístico/metabolismo
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