Aberration analysis of a projection-type CGH display with an expanded FOV based on the HOE screen.

This paper proposed a holographic optical element as a see-through screen for the computer-generated hologram projection system with 3D images. The proposed holographic screen consisted of a linear grating and a lens phase. The linear grating is used to redirect the information light and guide information into the observer's eye and achieve the see-through function. The lens phase is used to magnify the field of view of the holographic projection system. The aberration caused by the screen was analyzed in this paper and the aberration can be pre-corrected in the hologram calculation algorithm. Finally, the proposed system achieved 20.3 by 14.3 degrees field of view at 532 nm laser based on the spatial light modulator with 6.4 µm pixels.

Tunable focal waveguide-based see-through display with negative liquid crystal lens.

A see-through display based on a planar holographic waveguide with a tunable focal plane is presented. A negative liquid crystal lens is attached on the outcoupling location of the waveguide to manipulate the image distance. The continuous tunable range for the focal length is from negative infinity to -65 cm. The demonstrated prototype system provides 10.5° field-of-view (FOV) for the images not locating at infinity. The FOV for the images not locating at infinity is limited by the diameter of the liquid crystal lens. The lens function of the liquid crystal lens is polarization dependent. By controlling the polarization states of the real scene and the input information image, the liquid crystal lens keeps the see-through function for a real scene and simultaneously plays the role of a negative lens for the input information image. Compared to the see-through display system with a single focal plane, the presented system offers a more comfortable augmented reality (AR) experience.

Binocular dynamic holographic floating image display.

This paper proposes a binocular holographic floating display. The device consists of two phase-modulation spatial light modulators (SLM) and a dihedral corner reflector array (DCRA) element. The conjugate images of the SLMs generated by the DCRA become the system's exit pupils. Exit pupils that are larger than the pupils of human eyes are arranged to locate at the position of observer's eyes. Therefore, the dimension of the SLM will not limit the viewing angle, although the pixel pitch of the SLM still limits the maximum field of view. For the laser light source, the resolution of the images can achieve 3 arc minutes when the distance between images and DCRA is less than 20 cm. The full-color display function is also performed in the proposed device.

Astigmatism correction and quality optimization of computer-generated holograms for holographic waveguide displays.

In this manuscript, the astigmatism of the waveguide combiner with a pair of symmetry HOEs was analyzed. The light field can be predicted by the modified convolution formulation of Fresnel diffraction when the information of light passes through the astigmatism causing element. Then the astigmatism can be corrected. The theory was experimentally proved by the system with a phase-only SLM and a diffraction planar waveguide. Furthermore, the image quality of astigmatism corrected phase-type CGHs can be improved via the iteration process. Since the coherence of light source was employed, the temporal averaging method was utilized to avoid speckle noise.

Astigmatism and deformation correction for a holographic head-mounted display with a wedge-shaped holographic waveguide.

In this study, a head-mounted display (HMD) system based on a wedge-shaped holographic waveguide that can present holographic virtual images with tunable distance is achieved. The compact computer-generated-hologram system using a spatial light modulator was employed to offer the dynamic image, where the probe beam for the hologram reconstruction is a convergent wave, and the DC term of the diffraction wave can be blocked by a barrier. The wedge-shaped holographic waveguide element was used as the combiner of the HMD system to generate a compact structure. A wedge with a polished surface was designed for in-coupling the image into the waveguide, and a reflection-type holographic optical element (HOE) was used for out-coupling the image from the waveguide. The astigmatism aberration and deformation of the diffraction images at various distances are analyzed and then are compensated. Finally, the virtual image can be obtained without aberration with experimental verification.

Dispersion Differences and Consistency of Artificial Periodic Structures.

Dispersion differences and consistency of artificial periodic structures, including phononic crystals, elastic metamaterials, as well as periodic structures composited of phononic crystals and elastic metamaterials, are investigated in this paper. By developing a K(ω) method, complex dispersion relations and group/phase velocity curves of both the single-mechanism periodic structures and the mixing-mechanism periodic structures are calculated at first, from which dispersion differences of artificial periodic structures are discussed. Then, based on a unified formulation, dispersion consistency of artificial periodic structures is investigated. Through a comprehensive comparison study, the correctness for the unified formulation is verified. Mathematical derivations of the unified formulation for different artificial periodic structures are presented. Furthermore, physical meanings of the unified formulation are discussed in the energy-state space.

Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance tosorafenib in hepatocellular carcinoma cells.

Sorafenib is a multikinase inhibitor used as a first-line treatment for advanced hepatocellular carcinoma (HCC), but it has shown modest to low response rates. The characteristic tumour hypoxia of advanced HCC maybe a major factor underlying hypoxia-mediated treatment failure. Thus, it is urgent to elucidate the mechanisms of hypoxia-mediated sorafenib resistance in HCC. In this study, we found that hypoxia induced the nuclear translocation of Yes associate-Protein (YAP) and the subsequent transactivation of target genes that promote cell survival and escape apoptosis, thereby leading to sorafenib resistance. Statins, the inhibitors of hydroxymethylglutaryl-CoA reductase, could ameliorate hypoxia-induced nuclear translocation of YAP and suppress mRNA levels of YAP target genes both in vivo and in vitro. Combined treatment of statins with sorafenib greatly rescued the loss of anti-proliferative effects of sorafenib under hypoxia and improved the inhibitory effects on HepG2 xenograft tumour growth, accompanied by enhanced apoptosis as evidenced by the increased sub-G1 population and PARP cleavage. The expression levels of YAP and its target genes were highly correlated with poor prognosis and predicted a high risk of HCC patients. These findings collectively suggest that statins utilization maybe a promising new strategy to counteract hypoxia-mediated resistance to sorafenib in HCC patients.

Schottky diode fabricated on a single crystalline diamond rod.

The fabrication process of Al/diamond Schottky diodes on single crystalline diamond rods (SCDRs) was demonstrated. SCDRs of submicron diameters were obtained by etching a polished polycrystalline diamond film in oxygen plasma. The as-scratched SCDR was confirmed to be single crystalline diamond by electron diffraction measurements showing the same fuzzy spot pattern at different parts of an SCDR. Each SCDR was extracted from a grain in the polycrystalline film where the grain size served as a limit of the length of an SCDR. Al/Ti and Al metals were deposited to form ohmic and Schottky contacts, respectively. A hydrogen plasma treatment is an essential step prior to the formation of an Al/diamond Schottky contact in order to improve the device performance. The submicron scale Al/diamond Schottky diode exhibits a very high current density of 1.4 × 10(4) A cm(-2) at a forward bias (V(F)) voltage of - 3 V.