Trajectories of cognitive function among people aged 45 years and older living with diabetes in China: Results from a nationally representative longitudinal study (2011~2018).

OBJECTIVES: Diabetes is associated with decline of cognitive function. Exploring different trajectories of cognitive function occurring in people with diabetes is important to improved prognosis. This study aimed to investigate differential patterns of trajectories of cognitive function and baseline determinants of trajectory group membership utilizing data from middle-aged and older Chinese adults with diabetes. METHODS: Participants of the Chinese Health And Retirement Longitudinal Study (CHARLS) aged 45 years and above received biennial assessments between 2011 and 2018. The primary outcome was overall cognitive function score operationalized as sum of mental intactness and episodic memory scores derived from the Telephone Interview of Cognitive Status (TICS). A weighted growth mixture model was used to estimate cognitive function trajectories of CHARLS participants with diabetes, and baseline factors associated with trajectory group membership were investigated with weighted multinomial logistic regression. RESULTS: Data from 1,463 participants with diabetes aged 45 years and above were analyzed, a three-group trajectory model showed the best fit for overall cognitive scores: low baseline, linear declining (22.1%); moderate baseline, linear declining (37.5%) and high-stable (40.3%). Older participants, females, participants with low education, with nighttime sleep <6 h, without daytime napping habits, and with depressive symptoms were at a higher risk of unfavorable cognitive function trajectories. CONCLUSIONS: We identified heterogeneous trajectories of cognitive function among middle-aged and older people living with diabetes in China. Socially vulnerable groups including females, rural residents, and those with low education were at a higher risk for unfavorable trajectories. In health programs aimed at preventing and mitigating cognitive decline in individuals with diabetes more attention should be given to vulnerable groups. Reduced nighttime sleep, lack of daytime napping, and depressive symptoms appear to be modifiable risk factors.

Portfolio Optimization Model for Gold and Bitcoin Based on Weighted Unidirectional Dual-Layer LSTM Model and SMA-Slope Strategy.

Portfolio optimization is one of the most complex problems in the financial field, and technical analysis is a popular tool to find an optimal solution that maximizes the yields. This paper establishes a portfolio optimization model consisting of a weighted unidirectional dual-layer LSTM model and an SMA-slope strategy. The weighted unidirectional dual-layer LSTM model is developed to predict the daily prices of gold/Bitcoin, which addresses the traditional problem of prediction lag. Based on the predicted prices and comparison of two representative investment strategies, simple moving average (SMA) and Bollinger bands (BB), this paper adopts a new investment strategy, SMA-slope strategy, which introduces the concept of k-slope to measure the daily ups and downs of gold/Bitcoin. As two typical financial products, gold and Bitcoin are opposite in terms of their characteristics, which may represent many existing financial products in investors' portfolios. With a principle of $1000, this paper conducts a five-year simulation of gold and Bitcoin trading from 11 September 2016 to 10 September 2021. To compensate for the SMA and BB that may miss buying and selling points, 4 different parameters' values in the k-slope are obtained through particle swarm optimization simulation. Also, the simulation results imply that the proposed portfolio optimization model contributes to helping investors make investment decisions with high profitability.