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1.
Int J Mol Sci ; 20(13)2019 Jun 29.
Artículo en Inglés | MEDLINE | ID: mdl-31261890

RESUMEN

The global spread of bacterial resistance to antibiotics promotes a search for alternative approaches to eradication of pathogenic bacteria. One alternative is using photosensitizers for inhibition of Gram-positive and Gram-negative bacteria under illumination. Due to low penetration of visible light into tissues, applications of photosensitizers are currently limited to treatment of superficial local infections. Excitation of photosensitizers in the dark can be applied to overcome this problem. In the present work, dark antibacterial activity of the photosensitizer Rose Bengal alone and in combination with antibiotics was studied. The minimum inhibitory concentrations (MIC) value of Rose Bengal against S. aureus dropped in the presence of sub-MIC concentrations of ciprofloxacin, levofloxacin, methicillin, and gentamicin. Free Rose Bengal at sub-MIC concentrations can be excited in the dark by ultrasound at 38 kHz. Rose Bengal immobilized onto silicon showed good antibacterial activity in the dark under ultrasonic activation, probably because of Rose Bengal leaching from the polymer during the treatment. Exposure of bacteria to Rose Bengal in the dark under irradiation by electromagnetic radio frequency waves in the 9 to 12 GHz range caused a decrease in the bacterial concentration, presumably due to resonant absorption of electromagnetic energy, its transformation into heat and subsequent excitation of Rose Bengal.


Asunto(s)
Antibacterianos/farmacología , Fármacos Fotosensibilizantes/farmacología , Rosa Bengala/farmacología , Fármacos Fotosensibilizantes/efectos de la radiación , Ondas de Radio , Rosa Bengala/efectos de la radiación , Silicio/química , Staphylococcus aureus/efectos de los fármacos , Ondas Ultrasónicas
2.
Sensors (Basel) ; 17(9)2017 Aug 30.
Artículo en Inglés | MEDLINE | ID: mdl-28867776

RESUMEN

A quasi-optical multi-ray model for a short-range millimeter wave radar is presented. The model considers multi-path effects emerging while multiple rays are scattered from the target and reflected to the radar receiver. Among the examined scenarios, the special case of grazing ground reflections is analyzed. Such a case becomes relevant when short range anti-collision radars are employed in vehicles. Such radars operate at millimeter wavelengths, and are aimed at the detection of targets located several tens of meters from the transmitter. Reflections from the road are expected to play a role in the received signal strength, together with the direct line-of-sight beams illuminated and scattered from the target. The model is demonstrated experimentally using radar operating in the W-band. Controlled measurements were done to distinguish between several scattering target features. The experimental setup was designed to imitate vehicle near-ground millimeter wave radars operating in vehicles. A comparison between analytical calculations and experimental results is made and discussed.

3.
Artículo en Inglés | MEDLINE | ID: mdl-17645209

RESUMEN

An improved measurement method of complex permittivity of low loss polymer powders is suggested. The measurements are done in the mm-wave range using a quasi optical resonator. The 2-D corrugated mode exciter is employed to improve suppression of undesirable higher modes. The model used for reconstructing complex permittivity takes into account ohm losses of metal mesh coupling that provide better accuracy of the reconstructing procedure. An example illustrating this method is reported.


Asunto(s)
Rayos Infrarrojos , Magnetismo , Microondas , Polímeros/química , Polvos/química , Transferencia de Energía , Ensayo de Materiales
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