Randomized-controlled phase II clinical trial of a bacterially expressed recombinant hepatitis E vaccine.

The candidate recombinant hepatitis E vaccine, HEV 239, protect monkeys against infection by hepatitis E virus (HEV). The safety and immunogenicity of the vaccine for humans was assessed in a randomized controlled phase II clinical trial. The study was conducted in an endemic area of southern China and consisted of a dose scheduling, involving 457 adults and a dose escalation component involving 155 high school students. The results showed that the vaccine is safe and immunogenic for humans and suggest that it could prevent new HEV infection.

Poly[µ-5-ammonio-isophthalato-aqua-µ-oxalato-dysprosium(III)].

The title complex, [Dy(C(8)H(6)NO(4))(C(2)O(4))(H(2)O)](n), is a dysprosium coordination polymer with mixed anions and was obtained under hydrothermal conditions. In the structure, the oxalate and 5-amino-isophthalate ligands link the dysprosium ions, building up a two-dimensional metal-organic framework parallel to the (10) plane. These sheets are further connected through O-H⋯O, N-H⋯O and C-H⋯O hydrogen bonds, forming a three-dimensional supra-molecular structure.

catena-Poly[[[tetra-aqua-cobalt(II)]-µ-4,4'-bipyridine-κN:N'] 2-[4-(2-carboxyl-ato-eth-yl)phen-oxy]acetate].

In the title complex, {[Co(C(10)H(8)N(2))(H(2)O)(4)](C(11)H(10)O(5))}(n), the unique Co(II) ion lies on an inversion center and is coordinated by two N atoms from two 4,4'-bipyridine ligands and four O atoms from four water mol-ecules in a slightly distorted octa-hedral coordination geometry. The 4,4'-bipyridine ligands bridge Co(II) ions into a one-dimensional chain structure. In the crystal structure, inter-molecular O-H⋯O hydrogen bonds link cations and anions into a three-dimensional network. The dianions are completely disordered about an inversion center.

2-(2-Hydroxyphenyl)-4,5-dimethyl-1H-imidazol-3-ium acetate monohydrate.

In the title compound, C(11)H(13)N(2)O(+)·C(2)H(3)O(2) (-)·H(2)O, the dihedral angle between the benzene ring and the imidazole ring is 7.83 (6)°. In the crystal structure, N-H⋯O and O-H⋯O hydrogen bonds form a two-dimensional network. All the methyl H atoms are disorderd over two sites with equal occupancies.

6-Bromo-3-hydr-oxy-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid dimethyl-formamide disolvate.

In the title compound, C(16)H(9)BrO(5)·2C(3)H(7)NO, the chromene ring system is essentially planar. The two dimethyl-formamide solvent mol-ecules are linked by inter-molecular O-H⋯O hydrogen bonds to the 6-bromo-3-hydr-oxy-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid molecules.

Tetrakis[µ-3-(3-pyridyl)acrylato-κO:O']bis{(1,10-phenanthroline-κN,N')[3-(3-pyridyl)acrylato-κO,O']europium(III)} pentahydrate.

The europium(III) ion in the title compound, [Eu(2)(C(8)H(6)NO(2))(6)(C(12)H(8)N(2))(2)]·5H(2)O, is coordinated by seven carboxyl-ate O atoms and two N atoms from one phenanthroline mol-ecule. The carboxyl-ate groups of 3-(3-pyrid-yl)acrylate link pairs of europium(III) ions, forming centrosymmetric dinuclear units, which further assemble into a sheet parallel to the (001) plane through hydrogen-bonding inter-actions involving the uncoordinated water mol-ecules. One water molecule is disordered.

2,3:6,7-Bis(methyl-enedi-oxy)-phenanthrene.

In the title mol-ecule, C(16)H(10)O(4), all the non-H atoms are coplanar. The crystal structure is stabilized by weak inter-molecular C-H⋯O contacts and π-π stacking inter-actions (the inter-planar distance is 3.43 Å).

3,5-Dibromo-2-hydroxy-benzoic acid.

The title compound, C(7)H(4)Br(2)O(3), has an intra-molecular O-H⋯O=C hydrogen bond and aggregates to form hydrogen-bonded dimers via O-H⋯O inter-actions. The formation of zigzag one-dimensional mol-ecular tapes via C-H⋯Br inter-actions and π-π stacking inter-actions (inter-planar separation = 3.42 Å) completes the crystal structure.