RESUMEN
Aqueous zinc (Zn) batteries have been regarded as an alternative to lithium-ion batteries due to their high abundance, low cost, and higher intrinsic safety. However, the low Zn plating/stripping reversibility, Zn dendrite growth, and continuous water consumption have hindered the practical application of aqueous Zn anodes. Herein, a hydrous organic Zn-ion electrolyte based on a dual organic solvent, namely hydrated Zn(BF4)2 zinc salt dissolved in dimethyl carbonate (DMC) and vinyl carbonate (EC) solvents [denoted as Zn(BF4)2/DMC/EC], can address these problems, which not only inhibits the side reactions but also promotes uniform Zn plating/stripping through the formation of a stable solid state interface layer and Zn2+-EC/2DMC pairs. This electrolyte enables the Zn electrode to stably undergo >700 cycles at a rate of 1 mA cm-2 with a Coulombic efficiency of 99.71%. Moreover, the full cell paired with V2O5 also demonstrates excellent cycling stability without capacity decay at 1 A g-1 after 1600 cycles.
RESUMEN
Silver (Ag) has been demonstrated to have excellent performance to kill bacteria, fungi, and some viruses because it can release positively charged Ag ions with highly antibacterial and antifungal activities. However, effectively controlling the slow release of Ag ions is the key to preparing high-performance Ag-based antibacterial agents, which remains a challenge. In this work, we have developed a new Ag-based antibacterial agent composed of Ag ions loaded on 2D anionic 2D Sb3P2O14 3- nanosheets (denoted as Ag-Sb3P2O14). 2D anionic nanosheets not only adsorb a large amount of Ag ions but also control their slow release through electrostatic interaction between nanosheets and Ag ions. 2D Ag-Sb3P2O14 nanofillers enable excellent high antibacterial activities for the poly(vinylidene fluoride) (PVDF) film composites against microorganisms including Escherichia coli and Staphylococcus aureus. Moreover, the PVDF membrane with 5 wt % 2D Ag-Sb3P2O14 nanofillers can kill almost all bacterial after 50 times washing, demonstrating its excellent durable antibacterial activities. This work opens up a new and promising route to durable Ag-based antibacterial agents for polymer-based composites.
RESUMEN
[This corrects the article DOI: 10.3389/fcimb.2021.701820.].
RESUMEN
[This corrects the article DOI: 10.3389/fcimb.2021.701820.].
RESUMEN
Infection with Japanese encephalitis virus (JEV) induces high morbidity and mortality, including potentially permanent neurological sequelae. However, the mechanisms by which viruses cross the blood-brain barrier (BBB) and invade into the central nervous system (CNS) remain unclear. Here, we show that extracellular HMGB1 facilitates immune cell transmigration. Furthermore, the migration of immune cells into the CNS dramatically increases during JEV infection which may enhance viral clearance, but paradoxically expedite the onset of Japanese encephalitis (JE). In this study, brain microvascular endothelial cells (BMECs) were utilized for the detection of HMGB1 release, and leucocyte, adhesion, and the integrity of the BBB in vitro. Genetically modified JEV-expressing EGFP (EGFP-JEV) and the BBB model were established to trace JEV-infected immune cell transmigration, which mimics the process of viral neuroinfection. We find that JEV causes HMGB1 release from BMECs while increasing adhesion molecules. Recombinant HMGB1 enhances leukocyte-endothelium adhesion, facilitating JEV-infected monocyte transmigration across endothelia. Thus, JEV successfully utilizes infected monocytes to spread into the brain, expanding inside of the brain, and leading to the acceleration of JE onset, which was facilitated by HMGB1. HMGB1-promoted monocyte transmigration may represent the mechanism of JEV neuroinvasion, revealing potential therapeutic targets.
