Living Artificial Skin: Photosensitizer and Cell Sandwiched Bacterial Cellulose for Chronic Wound Healing.

Chronic wounds pose a significant global public health challenge due to their suboptimal treatment efficacy caused by bacterial infections and microcirculatory disturbances. Inspired by the biofunctionality of natural skin, an artificial skin (HV@BC@TBG) is bioengineered with bacterial cellulose (BC) sandwiched between photosensitizers (PS) and functionalized living cells. Glucose-modified PS (TBG) and vascular endothelial growth factor (VEGF)-functionalized living cells (HV) are successively modified on each side of BC through biological metabolism and bio-orthogonal reaction. As the outermost layer, the TBG layer can generate reactive oxygen species (ROS) upon light illumination to efficiently combat bacterial infections. The HV layer is the inner layer near the diabetic wound, which servs as a living factory to continuously secrete VEGF to accelerate wound repair by promoting fibroblast proliferation and angiogenesis. The sandwiched structural artificial skin HV@BC@TBG is nontoxic, biocompatible, and demonstrated its ability to significantly accelerate the healing process of infected diabetic wounds, rendering it a promising next-generation medical therapy for chronic wound management.

Impact of soil-atmosphere HONO exchange on concentrations of HONO and O3 in the North China Plain.

Nitrous acid (HONO) is an important precursor of the hydroxyl radical (OH) and plays a vital role in atmospheric photochemistry and nitrogen cycling. Soil emissions have been considered as a potential source of HONO. Lately, the HONO emission via soil-atmosphere exchange (ESA-exchange) from soil nitrite has been validated and quantified through chamber experiments, but has not been assessed in the real atmosphere. We coupled ESA-exchange and the other seven potential sources of HONO (i.e., traffic, indoor and soil bacterial emissions, heterogeneous reactions on ground and aerosol surfaces, nitrate photolysis, and acid displacement) into the Weather Research and Forecasting model with Chemistry (WRF-Chem), and found that diurnal variations of the soil emission flux at the Wangdu site were well simulated. During the non-fertilization period, ESA-exchange contributed ∼28 % and âˆ¼35 % of nighttime and daytime HONO, respectively, and enhanced the net ozone (O3) production rate by ∼8 % across the North China Plain (NCP). During the preintensive/intensive fertilization period, the maximum ESA-Exchange contributions attained ∼70 %/83 % of simulated HONO in the afternoon across the NCP, definitely asserting its dominance in HONO production. ESA-Exchange enhanced the OH production rate via HONO photolysis by ∼3.5/7.0 times, and exhibited an increase rate of ∼13 %/20 % in the net O3 production rate across the NCP. The total enhanced O3 due to the eight potential HONO sources ranged from ∼2 to 20 ppb, and ESA-exchange produced O3 enhancements of ∼1 to 6 ppb over the three periods. Remarkably, the average contribution of ESA-exchange to the total O3 enhancements remained ∼30 %. This study suggests that ESA-exchange should be included in three-dimensional chemical transport models and more field measurements of soil HONO emission fluxes and soil nitrite levels are urgently required.

[Characteristics，Sources，and Ozone-sensitive Species of VOCs in Four Seasons in Yuncheng].

Based on the one-year observational data of volatile organic compounds （VOCs） in an urban area of Yuncheng in 2021， the concentration， composition， sources， and ozone-sensitive species of VOCs in four seasons were analyzed. The results showed that the average annual concentration of VOCs was （32.1 ±24.2）×10-9， i.e.， at the national middle level. The seasonal concentrations of VOCs were in the order of： winter （46.3×10-9）> autumn （35.5×10-9）> spring （25.6×10-9）> summer （21.2×10-9）. Alkanes and OVOCs were the most dominant VOCs compounds， accounting for 69.0%-80.4% of TVOCs in Yuncheng. Affected by changes in source emissions， the proportion of OVOCs was higher in spring and summer （41%-43%）， whereas the proportion of alkanes was higher in autumn and winter （42%-43%）. Vehicle exhaust， LPG/NG， industrial production， and combustion sources were identified as the main sources of VOCs in Yuncheng. The largest contributors in the four seasons were vehicle exhaust （28.5% in spring）， secondary + combustion sources （29.0% in summer）， LPG/NG sources （30.4% in autumn）， and coal combustion （27.3% in winter）. The ozone formation was located in the transitional regime in summer and in the VOC-limited regime in other seasons. Ozone production was more sensitive to alkenes （isoprene， ethylene， and propene）， OVOCs （acetaldehyde and propanal）， and aromatics （xylene， toluene， and benzene）. Winter was more sensitive to ethylene， and the other seasons were more sensitive to isoprene. The primary emission sources related to these sensitive species should be reduced to achieve the goal of air quality improvement.

3D Printing of Anisotropic Piezoresistive Pressure Sensors for Directional Force Perception.

Anisotropic pressure sensors are gaining increasing attention for next-generation wearable electronics and intelligent infrastructure owing to their sensitivity in identifying different directional forces. 3D printing technologies have unparalleled advantages in the design of anisotropic pressure sensors with customized 3D structures for realizing tunable anisotropy. 3D printing has demonstrated few successes in utilizing piezoelectric nanocomposites for anisotropic recognition. However, 3D-printed anisotropic piezoresistive pressure sensors (PPSs) remain unexplored despite their convenience in saving the poling process. This study pioneers the development of an aqueous printable ink containing waterborne polyurethane elastomer. An anisotropic PPS featuring tailorable flexibility in macroscopic 3D structures and microscopic pore morphologies is created by adopting direct ink writing 3D printing technology. Consequently, the desired directional force perception is achieved by programming the printing schemes. Notably, the printed PPS demonstrated excellent deformability, with a relative sensitivity of 1.22 (kPa* wt. %)-1 over a substantial pressure range (2.8 to 8.1 kPa), approximately fivefold than that of a state-of-the-art carbon-based PPS. This study underscores the versatility of 3D printing in customizing highly sensitive anisotropic pressure sensors for advanced sensing applications that are difficult to achieve using conventional measures.

Effectiveness and safety of auricular acupuncture on adjuvant analgesia in patients with total knee arthroplasty: a randomized sham-controlled trial.

Objective: This study aimed to evaluate the effectiveness and safety of auricular acupuncture (AA) on postoperative analgesia, the degree of postoperative nausea, and the effect of inflammation after total knee arthroplasty (TKA). Methods: This was a single-center, placebo-controlled, randomized clinical trial. In total, 96 patients were randomly divided into an AA group with an indwelling intradermal needle (n = 48) and a sham auricular acupuncture (SAA) group with a non-penetrating placebo needle (n = 48). Intra-spinal anesthesia was adopted in both groups during surgery, and an epidural analgesic pump was implanted after surgery for 48 h. The primary outcome was the post-surgery visual analog score (VAS) of resting and movement states (at 6, 12 h and 1, 2, 3, 5, and 7 days). The secondary outcomes included additional doses of analgesic injection during the treatment, C-reactive protein (CRP) levels, erythrocyte sedimentation rate (ESR), and white blood cell (WBC) count on the 1st, 3rd, and 7th day after the operation, nausea on the 1st, 2nd, and 3rd day after the operation, the Hospital for Special Surgery Knee Score (HSS) on the 2nd and 12th week after the operation, and adverse events. Results: The VAS in the AA group at 6 h, 12 h, 2, 3, and 5 days after surgery were lower than those of the SAA group (p < 0.05). Among the secondary outcomes, the total dose of additional analgesic injection after surgery in the AA group was lower than that in the SAA group (p < 0.05). The serum CRP on the 1st day after operation in the AA group was lower than that in the SAA group (p < 0.05). The degree of nausea on 2nd day after surgery in the AA group was lower than that in the SAA group (p < 0.05). There was no significant difference in other outcomes (p > 0.05). Conclusion: In this study, AA was shown to be an effective and safe complementary and alternative therapy for pain relief after TKA, which was able to reduce the total postoperative dose of additional painkillers, decrease serum CRP 1 day after surgery, and improve the degree of postoperative nausea. Clinical trial registration: www.chictr.org.cn, ChiCTR2100054403.

Targeted platelet with hydrogen peroxide responsive behavior for non-alcoholic steatohepatitis detection.

The most common chronic liver illness, non-alcoholic fatty liver disease (NAFLD), refers to a range of abnormalities of the liver with varying degrees of steatosis. When the clinical symptoms including liver damage, inflammation, and fibrosis, are added to the initial steatosis, NAFLD becomes non-alcoholic steatohepatitis (NASH), the problematic and severe stage. The diagnosis of NASH at the right time could therefore effectively prevent deterioration of the disease. Considering that platelets (PLTs) could migrate to the sites of inflamed liver sinusoids with oxidative stress during the development of NASH, we purified the PLTs from fresh blood and engineered their surface with hydrogen peroxide (H2O2) responsive fluorescent probe (5-DP) through lipid fusion. The engineered PLT-DPs were recruited and trapped in the inflammation foci of the liver with NASH through interaction with the extracellular matrix, including hyaluronan and Kupffer cells. Additionally, the fluorescence of 5-DP on the surface of PLT-DP was significantly enhanced upon reacting with the elevated level of H2O2 in the NASH liver. Thus, PLT-DP has great promise for NASH fluorescence imaging with high selectivity and sensitivity.

Optimizing Analysis Methods: Rapid and Accurate Determination of Cuaminosulfate Residues with LC-MS/MS Based on Box-Behnken Design Study.

In view of the defects in the previous detection of cuaminosulfate, which only focused on the analysis of copper ions, there is currently no analysis method available to determine the actual state of cuaminosulfate as chelated or bound. In order to investigate the dissipation and terminal residues in soil and watermelon of cuaminosulfate for food safety and environmental risk, a highly effective technique was developed to detect cuaminosulfate residues in watermelon and soil, and field experiments were conducted in China. After single-factor experiments, residual cuaminosulfate in samples was extracted by pure water, purified using a liquid-liquid approach combined with a dispersive solid-phase extraction, and detected by liquid chromatography tandem mass spectrometry (LC-MS/MS). The Box-Behnken design (BBD) study was used to find the optimal solutions for the time of liquid-liquid purification, the amount of extraction solvent, and the amounts of cleanup sorbents for the analytical method. The average recovery of the method was in the range of 80.0% to 101.1%, the average relative standard deviation (RSD) was 5.3-9.9%, and the detection limit was lower than 0.05 mg/kg. The BBD study not only improved the extraction rate of the method, but also saved time and was operated easily. The final residues of cuaminosulfate in watermelon at different sampling intervals were all lower than 0.05 mg/kg under field conditions. The cuaminosulfate in soils dissipated following exponential kinetics, with half-life values in the range of 9.39 to 12.58 days, which varied by different locations. Based on the validated method, food safety residues and soil residues can be determined rapidly and accurately.

3D Printing Architecting ß-PVDF Reservoirs for Preferential ZnO Epitaxial Growth Toward Advanced Piezoelectric Energy Harvesting.

For polyvinylidene fluoride (PVDF) based piezoelectric composites, epitaxial growth of ZnO nanorods (ZnO-nr) piezoceramic layer on PVDF is an effective way to improve their piezoelectric performance. However, the crystal nucleus of ZnO featuring polar surfaces that cannot be directly attached to hydrophobic PVDF with low surface energy. Herein, direct ink writing (DIW) 3D printing is employed for the first time to create ß-PVDF reservoirs with significantly enhanced surface energy, facilitating the attachment and epitaxial growth of ZnO-nr. The printed ß-PVDF reservoirs designed with programmed macro-pores and abundant inner micropores, enable a higher loading of ZnO-nr by more than one magnitude, thereby boosting the electro-mechanical response. The resulting PVDF/ZnO core-shell piezoelectric energy harvester (PEH) delivers an output voltage of 33.2 V, as well as an unprecedentedly high relative output voltage of 2.76 V/wt.%, which is 2.63 times that of the state-of-the-art 3D-printed PVDF/piezoceramics PEHs. Furthermore, it can differentiate subtle human motions whereas hybrid PEHs cannot distinct. This work demonstrates that the DIW 3D printing approach offers a simple and convenient design idea for creating high performance PEHs.

Dominant physical and chemical processes impacting nitrate in Shandong of the North China Plain during winter haze events.

Nitrate has been a dominant component of PM2.5 since the stringent emission control measures implemented in China in 2013. Clarifying key physical and chemical processes influencing nitrate concentrations is crucial for eradicating heavy air pollution in China. In this study, we explored dominant processes impacting nitrate concentrations in Shandong of the North China Plain during three haze events from 9 to 25 December 2021, named cases P1 (94.46 (30.85) µg m-3 for PM2.5 (nitrate)), P2 (148.95 (50.12) µg m-3) and P3 (88.03 (29.21) µg m-3), by using the Weather Research and Forecasting/Chemistry model with an integrated process rate analysis scheme and updated heterogeneous hydrolysis of dinitrogen pentoxide on the wet aerosol surface (HET-N2O5) and additional nitrous acid (HONO) sources (AS-HONO). The results showed that nitrate increases in the three cases were attributed to aerosol chemistry, whereas nitrate decreases were due mainly to the vertical mixing process in cases P1 and P2 and to the advection process in case P3. HET-N2O5 (the reaction of OH + NO2) contributed 45 % (51 %) of the HNO3 production rate during the study period. AS-HONO produced a nitrate enhancement of 24 % in case P1, 12 % in case P2 and 19 % in case P3, and a HNO3 production rate enhancement of 0.79- 0.97 (0.18- 0.60) µg m-3 h-1 through the reaction of OH + NO2 (HET-N2O5) in the three cases. This study implies that using suitable parameterization schemes for heterogeneous reactions on aerosol and ground surfaces and nitrate photolysis is vital in simulations of HONO and nitrate, and the MOSAIC module for aerosol water simulations needs to be improved.

Trifloxystrobin induced developmental toxicity by disturbing the ABC transporters, carbohydrate and lipid metabolism in adult zebrafish.

The environmental risks of trifloxystrobin (TR) have drawn attention because of its multiplex toxicity on aquatic organisms, but few studies have paid close attention to its chronic toxicity at environmental concentrations. In present study, histopathology, metabolomics and transcriptomics were comprehensively performed to investigate the toxic effects and biological responses on adult zebrafish after exposure to 0.1, 1 and 10 µg/L TR for 21 d. Results demonstrated long-term exposure of TR affected zebrafish liver, ovary and heart development. Metabolomics revealed 0.1, 1 and 10 µg/L TR simultaneously decreased the carbohydrates enriched in glucose metabolism and ABC transporters pathways, such as glycogen, lactose, lactulose, maltose, maltotriose, d-trehalose, while 1 µg/L and 10 µg/L TR significantly increased many metabolites related to glycerophospholipid and sphingolipid metabolism in zebrafish liver. Transcriptomics showed TR activated the transcription of the Abcb4, Abcb5 and Abcb11 involved in ABC transporters, Pck1, Pfk, Hk, Gyg1a and Pygma related to glucose metabolism, as well as the Lpcat1, Lpcat4, Gpat2, Cers and Sgms in glycerophospholipid and sphingolipid metabolism. Results further demonstrated high concentration of TR strongly affected the DNA repair system, while low dose of TR caused pronounced effects on cardiomyocytes and oocyte regulation pathways at transcriptional levels. The results indicated the abnormal liver, gonad and heart development caused by TR might be ascribed to the disturbance of carbohydrates and lipid metabolism mediating by the Abcb4, Abcb5 and Abcb11 ABC transporters, and long-term exposure of environmental concentration of TR was sufficient to affect zebrafish normal metabolism and development.

INTEDE 2.0: the metabolic roadmap of drugs.

The metabolic roadmap of drugs (MRD) is a comprehensive atlas for understanding the stepwise and sequential metabolism of certain drug in living organisms. It plays a vital role in lead optimization, personalized medication, and ADMET research. The MRD consists of three main components: (i) the sequential catalyses of drug and its metabolites by different drug-metabolizing enzymes (DMEs), (ii) a comprehensive collection of metabolic reactions along the entire MRD and (iii) a systematic description on efficacy & toxicity for all metabolites of a studied drug. However, there is no database available for describing the comprehensive metabolic roadmaps of drugs. Therefore, in this study, a major update of INTEDE was conducted, which provided the stepwise & sequential metabolic roadmaps for a total of 4701 drugs, and a total of 22 165 metabolic reactions containing 1088 DMEs and 18 882 drug metabolites. Additionally, the INTEDE 2.0 labeled the pharmacological properties (pharmacological activity or toxicity) of metabolites and provided their structural information. Furthermore, 3717 drug metabolism relationships were supplemented (from 7338 to 11 055). All in all, INTEDE 2.0 is highly expected to attract broad interests from related research community and serve as an essential supplement to existing pharmaceutical/biological/chemical databases. INTEDE 2.0 can now be accessible freely without any login requirement at: http://idrblab.org/intede/.

Adsorption of acetochlor-contaminated water systems using novel P-doped biochar: Effects, application, and mechanism.

Given the serious threat of acetochlor (ACT) to the aquatic ecological environment, designing wastewater treatment-oriented adsorbents for the sustainable remediation of actual ACT-contaminated water is a promising yet challenging strategy. Herein, a novel P-doped biochar (PBC-800) with a high adsorption capacity (51.34 mg g-1) and a rapid reaction rate (47.35 mg g-1 h-1) for ACT was prepared through pyrolyzing of rice straw biomass pre-impregnated with potassium dihydrogen phosphate (KH2PO4). Additionally, P-doped biochars synthesized at different pyrolysis temperatures exhibited significant variations in ACT adsorption performance, which was mainly ascribed to the distinction between hydrophilicity and sp2 conjugate C (ID/IG = 0.84-1.08). The adsorption behavior of ACT on PBC-800 followed the Elovich kinetics and Freundlich adsorption isotherm models. Thermodynamic calculations indicated that the adsorption of ACT by PBC-800 was a spontaneously disordered decreasing exothermic process. Besides, PBC-800 exhibited a powerful anti-interference for ACT adsorption within complex water matrices, highlighting its potential for various of practical applications. Through characterization analysis and further experiments, it was proved that the excellent adsorption performance of PBC-800 on ACT was ascribed to a combination of physical and chemical adsorption mechanisms, including 57.5% pore filling, 23.4% hydrophobic interaction, 12.7% π-π interaction, and 6.4% hydrogen bonding. Moreover, PBC-800 exerted a prominent adhesion impact upon Gram-positive and negative bacteria at 3 h. This study offers a new idea for the utilization of agricultural residues and provides insights into the mechanism of ACT adsorption through its derived biochar.

Customizing Three-Dimensional Elastic Barium Titanate Sponge for Intelligent Piezoelectric Sensing.

Piezoelectric energy harvesters (PEHs) with porous structures, such as piezoelectric elastic sponges, exhibit high force-to-electricity conversion efficiencies owing to their excellent compression recovery properties. However, conventional preparation methods are limited to producing bulk-form sponge-like PEHs and fail to create more elaborate three-dimensional (3D) structures that could enhance conversion efficiency. Herein, we invent a composite ink consisting of waterborne polyurethane (WPU), barium titanate (BTO), and cellulose nanofibers (CNFs) that is suitable for direct ink writing (DIW) 3D printing. This ink, when coupled with freeze-drying, allows the customization of piezoelectric sponges with functional 3D structures. The printed lattice sponge exhibits remarkable compression recovery of 70% and a notably high relative sensitivity of 9.83 mV/kPa*wt % (where *wt % denotes the BTO content) across a wide pressure range of 2.98-37 kPa, which is approximately three times broader than those of other composite piezoelectric pressure sensors based on BTO or piezoceramic (PZT) materials. Furthermore, a customized 3D piezoelectric sponge with a "boomerang" configuration is utilized as an anisotropic bending sensor on the wrist for intelligently monitoring the stroke posture and programming scientific training for table tennis players. This study highlights a versatile strategy for constructing elastic sponges with high piezoelectricity and designing 3D PEH functional structures that can be applied to flexible self-powered intelligent sensing systems.

Specific volatiles of tea plants determine the host preference behavior of Empoasca onukii.

Empoasca onukii is a major pest that attacks tea plants. To seek effective and sustainable methods to control the pest, it is necessary to assess its host preference among different species of tea and understand the critical factors behind this behavior. In this study, the behavioral preference of E. onukii for volatile organic compounds (VOCs) of three potted tea species was evaluated. The VOCs released by the three tea species were analyzed using gas chromatography-mass spectrometry, and the major components were used to test the pest's preference. Transcriptome analysis was used to infer the key genes that affect the biosyntheses of the VOCs. The results showed that the tendency of E. onukii toward the VOCs of the three tea species was the strongest in green tea, followed by white tea, and the weakest in red tea. This behavioral preference was significantly and positively correlated with the relative levels of hexanol, linalool, and geraniol in tea volatiles. Relative hexanol was significantly and positively correlated with the expression of genes TEA009423 (LOX2.1), TEA009596 (LOX1.5), TEA008699 (HPL), TEA018669 (CYPADH), and TEA015686 (ADHIII). Relative linalool was significantly and positively correlated with the expression of genes TEA001435 (CAD) and Camellia_sinensis_newGene_22126 (TPS). Relative geraniol was significantly and positively correlated with the expression of genes TEA001435 (CAD), TEA002658 (CYP76B6), TEA025455 (CYP76T24), and Camellia_sinensis_newGene_22126 (TPS). The above findings suggested that three volatiles (hexanol, linalool, and geraniol) determined the behavioral preference of E. onukii toward tea plants, and their biosynthesis was mainly affected by nine genes (TEA009423, TEA009596, TEA008699, TEA018669, TEA015686, TEA001435, TEA002658, TEA025455, and Camellia_sinensis_newGene_22126).

Bioavailability evaluation of epoxiconazole and difenoconazole in rice and the influence of dissolved organic matter in reducing uptake and translocation.

The aim of this study was to assess the bioavailability of epoxiconazole (EPO) and difenoconazole (DIF) in rice plants by evaluating their uptake, translocation, and accumulation. The results showed that the concentration of DIF in the roots was approximately three times higher than EPO, and both accumulated mainly in the roots. In addition, EPO continued to be transported from stems to leaves, causing a rise in its concentration in leaves. Contrastingly, only a minimal amount of DIF was transported to the leaves. This phenomenon is mainly governed by their differing octanol-water partition coefficient. The effects of dissolved organic carbon (DOC) on the accumulation of EPO and DIF in the roots were similar to those of the freely dissolved concentration measured by OECAMs. The concentrations of EPO and DIF in the roots and OECAMs consistently decreased with increasing DOC levels. Furthermore, a significant linear relationship was observed between the EPO and DIF concentrations in root and OECAMs. We also confirmed the accuracy and usefulness of the OECAMs method in predicting the bioavailability of EPO and DIF in rice roots. Therefore, OECAMs show good potential for use as a passive sampler to evaluate the bioavailability of EPO and DIF.

Bioavailability assessment of difenoconazole to earthworms (Eisenia fetida) in soil by oleic acid-embedded cellulose acetate membrane.

Passive sampling technology is widely used to evaluate the bioavailability of pollutants. However, relatively few studies have used passive sampling membranes (PSMs) to evaluate the environmental risks of pollutants in soil, particularly pesticides. Here, the bioavailability of difenoconazole to earthworms (Eisenia fetida) was evaluated using an oleic acid-embedded cellulose acetate membrane (OECAM) for the first time. Difenoconazole reached 94 % equilibrium (T94%) within 1 d in OECAM. For soil pore water, the freely dissolved concentration (Cfree) of difenoconazole was determined using OECAM (R2 = 0.969). In the soil system, a strong linear correlation between the difenoconazole concentration in OECAM and earthworms was observed (R2 = 0.913). The bioavailability of difenoconazole was affected by the soil type and biochar content. The higher the content of soil organic matter and biochar, the lower the concentration of difenoconazole in earthworms, OECAM, and soil pore water. The concentrations of difenoconazole in pore water, earthworms, and OECAM decreased by 65.3, 42.0, and 41.6 %, respectively, when 0.5 % biochar was added. Difenoconazole mainly enters OECAM and earthworms through passive diffusion with similar uptake pathways. Therefore, the bioavailability of difenoconazole to earthworms in different soils can be evaluated using the OECAM.

Type-I Photosensitizer-Triggered Controllable Carbon Monoxide Release for Effective Treatment of Staph Skin Infection.

Staphylococcus aureus (S. aureus) infection is a major infectious skin disease that is highly resistant to conventional antibiotic treatment and host immune defense, leading to recurrence and exacerbation of bacterial infection. Herein, we developed a photoresponsive carbon monoxide (CO)-releasing nanocomposite by integrating anion-π+ type-I photosensitizer (OMeTBP) and organometallic complex (FeCO) for the treatment of planktonic S. aureus and biofilm-associated infections. After optimizing the molar ratio of FeCO and OMeTBP, the prepared nanoparticles, OMeTBP@FeCONPs, not only ensured sufficient loading of CO donors and efficient CO generation but also showed negligible free ROS leakage under light irradiation, which helped to avoid tissue damage caused by excessive ROS. Both in vitro and in vivo results demonstrated that OMeTBP@FeCONPs could effectively inhibit S. aureus methicillin-resistant S. aureus (MRSA), and bacterial biofilm. Our design has the potential to overcome the resistance of conventional antibiotic treatment and provide a more effective option for bacterial infections.

Enhanced secondary organic aerosol formation during dust episodes by photochemical reactions in the winter in Wuhan.

To investigate the effect of frequently occurring mineral dust on the formation of secondary organic aerosol (SOA), 106 volatile organic compounds (VOCs), trace gas pollutants and chemical components of PM2.5 were measured continuously in January 2021 in Wuhan, Central China. The observation period was divided into two stages that included a haze period and a following dust period, based on the ratio of PM2.5 and PM10 concentrations. The average ratio of secondary organic carbon (SOC) to elemental carbon (EC) was 1.98 during the dust period, which was higher than that during the haze period (0.69). The contribution of SOA to PM2.5 also increased from 2.75% to 8.64%. The analysis of the relationships between the SOA and relative humidity (RH) and the odd oxygen (e.g., OX = O3 + NO2) levels suggested that photochemical reactions played a more important role in the enhancement of SOA production during the dust period than the aqueous-phase reactions. The heterogeneous photochemical production of OH radicals in the presence of metal oxides during the dust period was believed to be enhanced. Meanwhile, the ratios of trans-2-butene to cis-2-butene and m-/p-xylene to ethylbenzene (X/E) dropped significantly, confirming that stronger photochemical reactions occurred and SOA precursors formed efficiently. These results verified the laboratory findings that metal oxides in mineral dust could catalyse the oxidation of VOCs and induce higher SOA production.

Aggregation-Induced Emission (AIE), Life and Health.

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health.

Electrospinning of Highly Bi-Oriented Flexible Piezoelectric Nanofibers for Anisotropic-Responsive Intelligent Sensing.

Flexible piezoelectric energy harvesters (PEHs) have gained substantial attention owing to their wearability, breathability, and sustainable self-powered supply. However, existing film PEHs cannot identify forces in different bending directions, limiting their applications in wearable electronics and artificial intelligence. This study constructs a fabric PEH for the first time by introducing piezoelectric anisotropic BaTi2 O5 nanorods (BT2-nr) into piezoelectric polyvinylidene fluoride (PVDF) nanofibers with a bi-oriented architecture, in which BT2-nr uniformly aligns in the PVDF nanofiber during electrospinning. The dual-orientation feature endows the flexible PEH with anisotropy, which can sensitively identify the forces at different bending directions (e.g., bent vertically, parallelly, or twisted by 45° along the fiber orientations). Simultaneously, the composite PVDF/BT2 PEH containing 15 wt.% BT2-nr delivers an optimal piezoelectric output of 31.2 V with a high sensitivity of 5.22 V N-1 . The developed anisotropic PEH can be used as a self-powered pressure sensor for multimodal intelligent biomonitoring of human movement. This study provides a feasible strategy for fabricating self-powered flexible PEHs with high electromechanical conversion efficiency and multifunctionality for wearable piezoelectric pressure sensors.