Optimization of Quartz Sand-Enhanced Coagulation for Sewage Treatment by Response Surface Methodology.

The quartz sand-enhanced coagulation (QSEC) is an improved coagulation method for treating water, which uses quartz sand as a heavy medium to accelerate the sedimentation rate of flocs and reduce the sedimentation time. The factors that influence the QSEC effect and can be controlled manually include the quartz sand dosage, coagulant dosage, sewage pH, stirring time, settling time, etc., and their reasonable setting is critical to the result of water treatment. This paper aimed to study the optimal conditions of QSEC; first, single-factor tests were conducted to explore the optimal range of influencing factors, followed by response surface methodology (RSM) tests to accurately determine the optimum values of significant factors. The results show that the addition of quartz sand did not improve the water quality of the coagulation treatment, it took only 140 s for the floc to sink to the bottom, and the sediment volume only accounted for 12.2% of the total sewage. The quartz sand dosage, the coagulant dosage, and sewage pH all had a significant impact on the coagulation effect, and resulted in inflection points. A QSEC-guiding model was derived through RSM tests, and subsequent model optimization and experimental validation revealed the optimal conditions for treating domestic sewage as follows: the polyaluminum chloride (PAC) dosage, cationic polyacrylamide (CPAM) dosage, the sewage pH, quartz sand dosage, stirring time, and settling time were 0.97 g/L, 2.25 mg/L, 7.22, 2 g/L, 5 min, and 30 min, respectively, and the turbidity of the treated sewage was reduced to 1.15 NTU.

Cortinarius and Tomentella Fungi Become Dominant Taxa in Taiga Soil after Fire Disturbance.

Fungi have important ecological functions in the soil of forests, where they decompose organic matter, provide plants with nutrients, increase plant water uptake, and improve plant resistance to adversity, disease, and disturbance. A forest fire presents a serious disturbance of the local ecosystem and can be considered an important component affecting the function of ecosystem biomes; however, the response of soil fungi to fire disturbance is largely unknown. To investigate the effects of fire disturbance on the community composition and diversity of soil fungi in a taiga forest, we collected soil from plots that had undergone a light, moderate, and heavy fire 10 years previously, with the inclusion of a fire-free control. The present soil fungi were characterized using Illumina MiSeq technology, and the sequences were analyzed to identify differences in the community composition and diversity in response to the changed soil physicochemical properties. The results showed that the Chao1 index, which characterizes the alpha diversity of the fungi, did not change significantly. In contrast, the Shannon index increased significantly (p < 0.05) and the Simpson index decreased significantly (p < 0.05) following a light or heavy fire disturbance compared to the control. The relative abundance of Basidiomycota was significantly higher in the soil of the fire sites than that in the control (p < 0.01), and the relative abundance of Ascomycota was significantly lower (p < 0.01). The results of principal coordinates analyses (PCoAs) showed that fire disturbance highly significantly affected the beta diversity of soil fungi (p < 0.001), while the results of canonical correlation analysis (CCA) indicated that the available nitrogen (AN), moisture content (MC), pH, available potassium (AK), and total nitrogen (TN) contents of the soil significantly affected the compositional structure and diversity of the soil fungal communities. The results of functional prediction showed that the majority of the detected soil fungi were symbiotrophs, followed by saprotrophs and saprotroph-symbiotrophs, with ectomycorrhiza being the dominant functional taxon. Fire disturbance significantly reduced the relative abundance of ectomycorrhiza (p < 0.05). This study illustrates that fire disturbance alters the structural composition, diversity, dominance, and relative abundance of the guilds of soil fungal communities in taiga forest, and strongly affected the beta diversity of soil fungi, with AN, MC, pH, AK, and TN being the most important factors affecting their community structure. The results may provide a useful reference for the restoration and rehabilitation of taiga forests after fire disturbance.

Transfer Prediction Method of Bearing Remaining Useful Life Based on Deep Feature Evaluation under Different Working Conditions.

In the existing bearing remaining useful life (RUL)-prediction model based on deep learning, the advantages and disadvantages of the extracted features are evaluated by the prediction accuracy; thus, the analytical ability of the features is poor. At the same time, the change of working conditions has a great influence on prediction accuracy. To overcome these limitations, a prediction method of bearing RUL based on feature evaluation and deep transfer learning is proposed. The proposed model can solve the above problems: (1) a method of feature evaluation and selection for bearing life prediction based on trend consistency index was designed. (2) In this study, a domain adversarial transfer model based on feature condition mapping is proposed to overcome the second limitation. Experimental results show that this method is superior to the existing bearing evaluation and prediction methods.

Formation and Evolution Mechanism of Intermetallic Compounds of Friction Stir Lap Welded Steel/Aluminum Joints.

Interfacial layers with brittle intermetallic compounds (IMC) greatly influence the performance of steel-aluminum friction stir lap welding (FSLW) joints. Thus, the formation and evolution of IMC between 7075-T6 aluminum alloy and galvanized DP590 steel in steel-aluminum FSLW joints were investigated. An FSLW numerical model was developed using the computational fluid dynamics method to analyze the interface temperature between the aluminum alloy and steel. Scanning electron microscopy (SEM) was conducted to observe the microstructure characterization and measure the IMC thickness. Phases among different joint zones were analyzed by X-ray diffraction (XRD) and energy dispersive spectroscopy (EDS). IMC layer formation was predicted by the effective Gibbs free energy model presented in this paper according to thermodynamic principles. The Monte Carlo method was utilized to predict the thickness of IMC layers. It was found that the IMC layer at the interface of the welded joint is composed of Fe2Al5, FeAl3, and Al-Zn eutectic. The IMC thickness decreased from 4.3 µm to 0.8 µm with the increasing welding speed, which was consistent with the Monte Carlo simulation results.

Proteomics Analysis of Polyphyllin D-Treated Triple-Negative Breast Cancer Cells Reveal the Anticancer Mechanisms of Polyphyllin D.

Polyphyllin D (PD), one of the important steroid saponins in traditional medicinal herb Paris polyphylla, has been demonstrated to have anticancer activity both in vitro and in vivo. However, the mechanisms through which PD exerts its anticancer effects in triple-negative breast cancer (TNBC) remain unclear. Our study was presented to evaluate the anticancer effect and the potential mechanisms of PD in two TNBC cell lines, BT-549 and MDA-MB-231. Through comprehensively comparing the liquid chromatography-tandem mass spectrometry (LC-MS/MS) data of PD-treated and untreated BT-549 and MDA-MB-231 cells, we found that PD could induce apoptosis of TNBC cells by activating oxidative phosphorylation pathway in BT-549 cells, as well as inhibiting spliceosome function alteration in MDA-MB-231 cells. These results suggested that the mechanisms underlying the pro-apoptotic effect of PD on TNBC may be cell type-specificity-dependent. Moreover, we found that nodal modulator 2/3 (NOMO2/3) were downregulated both in PD-treated BT-549 and MDA-MB-231 cells, suggesting that NOMO2/3 may be the potential target of PD. Verification experiments revealed that PD deceased NOMO2/3 expression at protein level, rather than mRNA level. Whether NOMO2/3 are the upstream modulators of oxidative phosphorylation pathway and spliceosome needs further validation. In conclusion, a comprehensive proteomics study was performed on PD-treated or untreated TNBC cells, revealing the anticancer mechanisms of PD.

Reduced Arbuscular Mycorrhizal Fungi (AMF) Diversity in Light and Moderate Fire Sites in Taiga Forests, Northeast China.

Forest fires are an important disturbance factor in forest ecosystems, and obviously change the soil environment. Arbuscular mycorrhizal fungi, as a medium and bridge between vegetation and soil, play a crucial role in mediating plant nutrient uptake and regulating the productivity, stability, and succession of vegetation-soil systems. To investigate the effects of forest fires on the community structure and diversity of arbuscular mycorrhizal fungi in cold-temperate Larix gmelinii forests, we collected soils from light, moderate, and heavy fire disturbance forests and a natural forest as a control forest in Greater Khingan Larix gmelinii forests, in the northeast of China. The community structure and diversity of arbuscular mycorrhizal fungi was sequenced using Illumina MiSeq technology and we analyzed the correlation with the soil physicochemical characteristics. The results showed that the contents of microbial biomass content (MBC), moisture content (MC), total nitrogen (TN), and available phosphors (AP) increased significantly (p < 0.05) with increasing fire intensity (from Light to heavy fire), but available potassium (AK) decreased significantly (p < 0.05). These changes were not significant. A total of 14,554 valid sequences from all sequences were classified into 66 ASVs that belonged into one phylum, one order, four families, and four genera. The genera included Glomus, Ambispora, Paraglomus, and Acaulospora, and Glomus was the dominant genus (the genera with the five most relative abundances) in the control and heavy-fire forests. Non-metric multidimensional scaling (NMDS) analysis showed that forest fires significantly affected the community structure of arbuscular mycorrhizal fungi (p < 0.01). Redundancy analysis (RDA) showed that MBC, SOC, and AP contents significantly affected the composition structure and diversity of arbuscular mycorrhizal fungi communities. This study indicated that forest fires affected the composition and diversity of soil arbuscular mycorrhizal fungi communities through changing the soil physicochemical parameters (MBC, SOC, and AP) in cold-temperate Larix gmelinii forests. The study of soil physicochemical properties and arbuscular mycorrhizal fungi diversity in cold-temperate Larix gmelinii forests in the Greater Khingan Mountains after forest fires provides a reference basis for the revegetation and reconstruction of fire sites.

Umbelliprenin induces autophagy and apoptosis while inhibits cancer cell stemness in pancreatic cancer cells.

BACKGROUND: Umbelliprenin is a sesquiterpene coumarin isolated from Artemisia absinthium L. and shows antitumor effects in various cancers by inducing apoptosis. However, the antitumor effect of umbelliprenin in human pancreatic cancer has not been clarified. METHODS: The antitumor effects were determined by MTT and AnnexinV/PI double staining assay in vitro and xenograft mice in vivo. Autophagy was determined via immunofluorescence analysis. Apoptotic or autophagic related proteins were measured by immunoblotting. The pancreatic cancer cell stemness were determined by mammosphere formation and ALDEFLUOR assay. RESULTS: It revealed that umbelliprenin inhibited pancreatic cancer cell proliferation in vitro and pancreatic cancer tumor growth in vivo. Moreover, umbelliprenin induced pancreatic cancer cell BxPC3 apoptosis and autophagy as evidenced by upregulated apoptosis and autophagy- related protein expression (p < 0.01). Blocking autophagy by 3-MA or Atg7 knockout enhanced umbelliprenin-induced apoptosis (p < 0.05). Umbelliprenin also reduced pancreatic cancer cell stemness by reducing Oct4, Nanog, and Sox2 mRNA levels (p < 0.01). Mechanistically, umbelliprenin greatly inhibited Akt/mTOR and Notch1 signal pathway. CONCLUSION: Umbelliprenin may be a novel therapeutic approach for pancreatic cancer treatment.

The AMP-Activated Protein Kinase (AMPK) Positively Regulates Lysine Biosynthesis Induced by Citric Acid in Flammulina filiformis.

Flammulina filiformis, the most produced edible mushroom species in China, is rich in lysine. Further enhancing its lysine biosynthesis is vital for improving its quality in industrialized cultivation. Citric acid induction significantly increases both the biomass and growth rate of F. filiformis hyphae, as well as the lysine content. The genes encoding enzymes in the lysine biosynthesis pathway were detected under the optimal induction, revealing that the expression levels of hcs, hac, and hah were 2.67, 1.97, and 1.90 times greater, respectively, relative to the control, whereas no significant difference was seen for hdh, aat, sr, and shd, and the expression of aar decreased. Furthermore, the transcriptional levels of Ampk, GCN2, GCN4, and TOR were found significantly upregulated, with the most upregulated, Ampk, reaching a level 42.68 times greater than that of the control, while the phosphorylation of AMPK rose by nearly 54%. In AMPK-silencing strains under the optimal induction, however, the phosphorylation increment dropped to about 16% and the lysine content remained at the same level as in the WT. Thus, AMPK is presented as the critical intermediary in citric acid's regulation of lysine biosynthesis in F. filiformis.

Pachymic Acid Inhibits Growth and Metastatic Potential in Liver Cancer HepG2 and Huh7 Cells.

Pachymic acid (PA), exacted from Polyporaceae, has been known for its biological activities including diuretic, dormitive, anti-oxidant, anti-aging, anti-inflammatory and anticancer properties in several types of diseases. Recently, studies have demonstrated that PA could suppress cell growth and induce cell apoptosis in different kinds of cancer cells. But the underlying mechanisms remain poorly elucidated. In the current study, we investigated the effect of pachymic acid on liver cancer cells and its underlying mechanisms. Our results evidenced that pachymic acid effectively inhibited the cell growth and metastatic potential in HepG2 and Huh7 cells. Mechanistically, we revealed that pachymic acid triggered cell apoptosis by increasing caspase 3 and caspase 9 cleavage, upregulating Bax and cytochrome c expression, while reducing the expression of Bcl2. Besides, pachymic acid could markedly inhibit the cell invasion and migration and cell metastatic potential by mediating epithelial-to-mesenchymal transition (EMT) markers and metastasis-associated genes in HepG2 and Huh7 cells. In addition, we demonstrated that FAK-Src-Jun N-terminal kinase (JNK)-matrix metalloproteinase 2 (MMP2) axis was involved in PA-inhibited liver cell EMT. Together, these results contribute to our deeper understanding of the anti-cancer effects of pachymic acid on liver cancer cells. This study also provided compelling evidence that PA might be a potential therapeutic agent for liver cancer treatment.

Transcriptome Analysis Reveals a Comprehensive Virus Resistance Response Mechanism in Pecan Infected by a Novel Badnavirus Pecan Virus.

Pecan leaf-variegated plant, which was infected with a novel badnavirus named pecan mosaic virus (PMV) detected by small RNA deep sequencing, is a vital model plant for studying the molecular mechanism of retaining green or chlorosis of virus-infected leaves. In this report, PMV infection in pecan leaves induced PAMP-triggered immunity (PTI) and effector-triggered immunity (ETI). PMV infection suppressed the expressions of key genes of fatty acid, oleic acid (C18:1), and very-long-chain fatty acids (VLCFA) biosynthesis, indicating that fatty acids-derived signaling was one of the important defense pathways in response to PMV infection in pecan. PMV infection in pecans enhanced the expressions of pathogenesis-related protein 1 (PR1). However, the transcripts of phenylalanine ammonia-lyase (PAL) and isochorismate synthase (ICS) were downregulated, indicating that salicylic acid (SA) biosynthesis was blocked in pecan infected with PMV. Meanwhile, disruption of auxin signaling affected the activation of the jasmonic acid (JA) pathway. Thus, C18:1 and JA signals are involved in response to PMV infection in pecan. In PMV-infected yellow leaves, damaged chloroplast structure and activation of mitogen-activated protein kinase 3 (MPK3) inhibited photosynthesis. Cytokinin and SA biosynthesis was blocked, leading to plants losing immune responses and systemic acquired resistance (SAR). The repression of photosynthesis and the induction of sink metabolism in the infected tissue led to dramatic changes in carbohydrate partitioning. On the contrary, the green leaves of PMV infection in pecan plants had whole cell tissue structure and chloroplast clustering, establishing a strong antiviral immunity system. Cytokinin biosynthesis and signaling transductions were remarkably strengthened, activating plant immune responses. Meanwhile, cytokinin accumulation in green leaves induced partial SA biosynthesis and gained comparatively higher SAR compared to that of yellow leaves. Disturbance of the ribosome biogenesis might enhance the resistance to PMV infection in pecan and lead to leaves staying green.

Variations of tunnelling resistance between CNTs with strain in composites: non-monotonicty and influencing factors.

The electro-mechanical response of conductive carbon-nanotube(CNT)-polymer composites is vital when they are used as smart-sensing materials. Clarifying the variation trend of resistance with strain is the key to design and regulate the piezoresistive property of such material. Here, we present some finite element simulations to predict the electro-mechanical response using a geometrical model comprising two hollow cylindrical CNTs and a cuboid matrix. The electrical contact between CNTs is represented by some elements which account for quantum tunnelling effects and capture the sensitivity of conductivity to separation. Different from classical simulations using solid model or one-dimensional beam model, in which the tunnelling resistance between two CNTs changes monotonously with strain, the results in this work show that the trend is non-monotonic in some cases, i.e. it increases at first and then decreases with the uniaxial compressive strain when the elastic modulus of the matrix is high. In addition, factors affecting the different variation trends are discussed in details, which include geometric model, elastic modulus and Poisson's ratio of the matrix, and orientation angle.

High Sensitivity and a Wide Sensing Range Flexible Strain Sensor Based on the V-Groove/Wrinkles Hierarchical Array.

Flexible strain sensors occupying a large part of human body detection and wearable electronics, which have a wide sensing range and high sensitivity, are crucial in fully monitoring human motion signals. This study proposed a strategy to construct flexible strain sensors based on the V-groove/wrinkles hierarchical array. The V-groove array was prepared on a polydimethylsiloxane (PDMS) substrate through mold transfer printing. The gold film was sputtered on the prestretching PDMS substrate, and the V-groove/wrinkles hierarchical array was formed after strain release. Compared with the sensors based on single-scale wrinkle structures and a V-groove array, the fabricated strain sensor with the hierarchical array showed high sensitivity (maximum gauge factor up to 2,557.71) and a wide sensing range (up to 45%). In addition, the dynamic characteristics of the sensor were investigated in detail, indicating that the sensor had a fast response (less than 130 ms), a low detection limit (0.1% strain), and good stability (almost no performance loss after 10,000 cycles). In practical applications, the sensor was used to detect sizable physical motion and weak physiological signals, demonstrating great potential application value in human motion detection. This study could provide new ideas for preparing high-performance flexible strain sensors.

Severe tinnitus and migraine headache in a 37-year-old woman treated with trastuzumab for breast cancer: A case report.

BACKGROUND: Trastuzumab is a generally safe agent prescribed in the systemic treatment of breast cancer. Tinnitus is not a currently known adverse event related to trastuzumab. Here, we describe a rare case of severe tinnitus and a migraine headache induced by trastuzumab used for adjuvant therapy. CASE SUMMARY: A 37-year-old woman was diagnosed with hormone receptor-positive and human epidermal growth factor receptor 2-positive breast cancer. After surgery, she was treated with four cycles of epirubicin and cyclophosphamide; she then received docetaxel and a loading dose of trastuzumab plus pertuzumab. Less than half an hour after trastuzumab infusion, the patient complained of severe tinnitus and left-sided migraine headache. Trastuzumab monotherapy was discontinued immediately, and symptoms disappeared after 10 min. Trastuzumab was readministered, and severe tinnitus and migraine headache recurred. Trastuzumab was stopped, and severe tinnitus diminished after 10 min. Pertuzumab and docetaxel therapy was then administered, and no adverse events were observed. Subsequent infusions of trastuzumab every three weeks did not show the same symptoms. CONCLUSION: Although trastuzumab is well-tolerated in most patients, we should pay attention to the risk of severe tinnitus and migraine.

Fabrication of 2H/3C-SiC heterophase junction nanocages for enhancing photocatalytic CO2 reduction.

The morphology and structure of photocatalyst play an important role in photocatalytic activity. SiC semiconductor is considered as a promising material for the photocatalytic CO2 reduction due to its negative conduction band position. Herein, SiC nanocages is creatively synthesized by simple low-temperature molten-salt-mediated magnesiothermic reduction method with using SiO2 as template. The morphology and phase composition of SiC nanocages can be controlled by magnesium dosage and reaction temperature. The 2H and 3C crystal phase in SiC nanocage can form heterophase junctions uniformly to effectively accelerate the photogenerated electron transfer, and plays a key role in improving the photocatalytic activity of 2H/3C-SiC samples. The optimal SiC nanocage sample possesses a CO generation rate of 4.68 µmol g-1h-1 for photocatalytic CO2 reduction, which is 3.25 times higher than that of commercial SiC.

High-efficiency removal of lead/cadmium from wastewater by MgO modified biochar derived from crofton weed.

The adsorption performance and mechanisms of Pb2+ and Cd2+ in wastewater using MgO modified biochar derived from crofton weed (MBCW600) are investigated. The Pb2+ and Cd2+ adsorption capacities of MBCW600 by the Hill model reach 384.08 mg/g and 207.02 mg/g, respectively, which is larger than that of original biochar. Pb2+ could be more easily captured by MBCW600 compared to Cd2+ in the multimetal system. Mg2+ contributes to Pb2+ and Cd2+ adsorption among coexisting cations. The exhausted MBCW600 could be well regenerated by simple method after use. The adsorption mechanism study indicates that Pb2+ and Cd2+ removal are primary contributed to mineral precipitation and ion exchange. The effective treatment volumes of Pb2+ and Cd2+ wastewater achieve 3050 mL and 2150 mL in the fixed-bed column experiment, respectively. Therefore, MBCW600 presents remarkable adsorption capability, excellent recoverability and large throughput, which shows the potential application in future treatment of wastewater containing heavy metal.

Polyphyllin D induces apoptosis and protective autophagy in breast cancer cells through JNK1-Bcl-2 pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Polyphyllin D (PD), an active component from rhizome of Paris polyphylla Sm, root and rhizome, shows a strong anti-cancer activity in several cancers. However, whether autophagy is involved in PD-induced cell death in breast cancer cells and its molecular mechanism has not yet been elucidated. AIM OF THE STUDY: To explore the anti-tumor effects of PD in breast cancer and the underlying mechanisms. MATERIALS AND METHODS: PD was isolated from P. polyphylla Sm and confirmed by HPLC and NMR. The role of PD in cell viability, apoptosis, autophagy in breast cancer cells were determined. RESULTS: PD shows significant anti-tumor activity by inhibit cell proliferation and induce caspase-dependent apoptosis in breast cancer cells. Moreover, PD treatment could induce autophagy by activation of JNK1/Bcl-2 pathway. Importantly, blocking of autophagy by using autophagy inhibitor 3-methyladenine (3-MA) dramatically increase PD-induced apoptosis as evidence by the increased percentage of apoptotic cell death. The anti-tumor effects of PD also investigated in vivo. The results showed that the combinatory treatment of PD with autophagy inhibitor significantly promote PD-induced apoptosis. CONCLUSION: PD could induce caspase-dependent apoptosis and cyto-protectvie autophagy by activation of JNK1/Bcl-2 pathway in breast cancer cells. Combination with an autophagy inhibitor significantly enhance cytotoxic effect of PD and this combination may be a promising candidate for breast cancer therapy.

Below-Ground Growth of Alpine Plants, Not Above-Ground Growth, Is Linked to the Extent of Its Carbon Storage.

Understanding carbon allocation in plants is essential for explaining their growth strategies during environmental adaptation. However, the role of mobile carbon in plant growth and its response to habitat conditions is still disputed. In degraded meadow (alpine sandy grassland) and non-degraded meadow (typical alpine meadow and swamp meadow) on the Qinghai-Tibetan Plateau, we measured the monthly averages of above-ground biomass (AGB) and below-ground biomass (BGB) of the investigated species in each meadow and the average concentration of non-structural carbohydrates (NSCs), an indicator of carbon storage. Below-ground organs had higher concentrations and showed more seasonal variation in NSCs than above-ground organs. BGB had a positive correlation with below-ground NSCs levels. However, AGB had no clear relationship with above-ground NSCs levels. Plants in sandy grasslands had higher total NSC, soluble sugars, fructose, and sucrose concentrations and lower starch concentrations in below-ground organs than plants in alpine or swamp meadows. Overall, NSCs storage, particularly soluble sugars, is a major process underlying the pattern of below-ground growth, but not above-ground growth, in the meadow ecosystem of the Qinghai-Tibetan Plateau, and degraded meadow strengthens this process. These results suggest that the extent of carbon storage in non-photosynthetic organs of alpine herbs impacts their growth and habitat adaptation.

The Effectiveness of Cochlear Implantation for Children of Hereditary Deafness: A Multicenter Retrospective Study.

Aim: To study the effectiveness of cochlear implantation in deaf children with gene mutation. Method: 420 children from three medical centers with cochlear implants were selected. Before wearing the cochlear implant and 6 months after wearing the cochlear implant, the children's rehabilitation efficacy was evaluated through categories of auditory performance (CAP) and speech intelligibility rating (SIR). The SSF-MCDI and MUSS before and after the treatment were also compared. Results: The CAP and SIR scores of the children after the intervention were higher than those before the intervention (P < 0.05). Univariate analysis found that the age of cochlear implantation, parents' education level, and monthly family income were all influencing factors of the CAP score of children with prelingual cochlear implantation (P < 0.05). Multivariate logistic regression analysis shows that the age of cochlear implantation <5 years, parents' education level, and monthly household income are all independent risks of CAP scores in children with prelingual deaf cochlear implantation. Univariate analysis found that the age of cochlear implantation, parents' education level, and monthly household income are all based on the SIR scores of children with prelingual cochlear implantation. Multivariate logistic regression analysis can be obtained: the age of cochlear implantation less than 5 years, the education level of parents, and the monthly family income are independent risk factors for SIR scores in children with prelingual deaf cochlear implantation (P < 0.05). Conclusion: The rehabilitation effect of cochlear implants is significant, and the age of cochlear implantation, parents' education level, and monthly family income are all related factors that affect the rehabilitation effect.

Axially torsional Meckel's diverticulum accompanied by small bowel volvulus: a case report.

Small bowel volvulus secondary to Meckel's diverticulum is rare, and a delayed diagnosis results in disastrous outcomes. Computed tomography is conducive to early differential diagnosis. In particular, a blind-ending pouch structure on CT always indicates Meckel's diverticulum. Diverticulectomy with or without adjacent partial small intestinal resection is the standard treatment for symptomatic Meckel's diverticulum. However, the therapy for asymptomatic Meckel's diverticulum is controversial. Here, we report the case of a 20-year-old man who suffered intestinal obstruction secondary to small bowel volvulus caused by an axially torsional, gangrenous, and giant Meckel's diverticulum. Diverticulectomy with partial intestinal resection was performed.