RESUMEN
1,25(OH)2D3 has already been reported to function in some diseases. However, its role in hyperlipidemia (HLP) remains unknown. This study aims to investigate the effect of 1,25(OH)2D3 on HLP rats. Rat models were established by high-fat diet feeding, perfusion of different doses of 1,25-(OH)2D3 and injection of TGF-ß1 siRNA. Whole blood viscosity, plasma viscosity, hematocrit, and erythrocyte aggregation index were detected, together with levels of biochemical indexes, 6-keto-PGF1α, and TXB2 in serum. Levels of oxidative stress indexes and inflammatory factors in serum and liver tissues were determined. TGF-ß1 and Smad3 expression in serum, liver tissues, and aorta was detected. 1,25(OH)2D3 lowered HLP-induced rise of whole blood viscosity, red blood cell aggregation index, plasma viscosity, and hematocrit, TC, TG, LDL-C, apoB, ALT, AST, TXB2, MDA, IL-1ß, TNF-α, and increased HLP-induced decrease of HDL-C, apoAI, 6-keto-PGF1α, SOD, GSH-Px, CAT, and T-AOC. TGF-ß1 and Smad3 expression in serum, liver tissue, and aorta of 1,25(OH)2D3-treated rats reduced. High 1,25(OH)2D3 dose and inhibited TGF-ß/Smad signaling pathway alleviated lipid metabolism, liver function, and atherosclerotic injury in HLP rats. Our study found that 1,25(OH)2D3 improves blood lipid metabolism, liver function, and atherosclerosis injury by constraining the TGF-ß/Smad signaling pathway in rats with HLP.
Asunto(s)
Aterosclerosis/tratamiento farmacológico , Calcitriol/uso terapéutico , Hiperlipidemias/metabolismo , Metabolismo de los Lípidos/efectos de los fármacos , Proteína smad3/sangre , Factor de Crecimiento Transformador beta1/sangre , 6-Cetoprostaglandina F1 alfa/sangre , Animales , Aorta Abdominal/citología , Aorta Abdominal/diagnóstico por imagen , Aorta Abdominal/efectos de los fármacos , Aorta Abdominal/metabolismo , Aterosclerosis/metabolismo , Aterosclerosis/patología , Viscosidad Sanguínea/efectos de los fármacos , Viscosidad Sanguínea/genética , Calcitriol/farmacología , HDL-Colesterol/sangre , LDL-Colesterol/sangre , Dieta Alta en Grasa/efectos adversos , Modelos Animales de Enfermedad , Eritrocitos/efectos de los fármacos , Eritrocitos/metabolismo , Silenciador del Gen , Hiperlipidemias/sangre , Hiperlipidemias/enzimología , Hiperlipidemias/patología , Inflamación/metabolismo , Metabolismo de los Lípidos/genética , Hígado/efectos de los fármacos , Hígado/metabolismo , Hígado/patología , Hígado/ultraestructura , Microscopía Electrónica de Transmisión , Estrés Oxidativo/efectos de los fármacos , Estrés Oxidativo/genética , ARN Interferente Pequeño , Ratas , Proteína smad3/genética , Proteína smad3/metabolismo , Tromboxano B2/sangre , Factor de Crecimiento Transformador beta1/genética , Factor de Crecimiento Transformador beta1/metabolismoRESUMEN
BACKGROUND: Use of intensive anticoagulation and antiplatelet therapy in acute myocardial infarction (AMI) potentially increases the risk of bleeding complications during percutaneous coronary intervention via the transfemoral route. Recently, the transradial access has been intensively employed as an alternative means for diagnostic and interventional procedures. A low incidence of vascular access site bleeding complications suggests that the transradial access is a safe alternative to the transfemoral technique in patients with AMI. The safety and efficacy of transradial access for emergent percutaneous coronary intervention in patients with AMI has not been investigated in the People's Republic of China. METHODS: We analyzed data from our single-center registry on 596 consecutive patients between October 2003 and October 2010. The patients were retrospectively divided into a transradial group (n = 296) and a transfemoral group (n = 300). A dedicated doctor was appointed to collect the following data: puncture time, coronary angiography time, percutaneous coronary intervention time, X-ray exposure time, duration of hospitalization, and complication rates associated with puncture, such as puncture site bleeding, hematoma, pseudoaneurysm, and major adverse cardiac events. RESULTS: There were no significant differences in baseline characteristics and angiographic findings between the two groups. There were also no significant differences in coronary angiography time (8.2 ± 2.4 versus 7.6 ± 2.0 minutes), percutaneous coronary intervention time (30 ± 6.8 versus 29.6 ± 8.1 minutes), or X-ray exposure time (4.6 ± 1.4 versus 4.4 ± 1.3 minutes) between the groups. There were significant differences in puncture time (4.4 ± 1.6 versus 2.4 ± 0.8 minutes) and duration of hospitalization (3.2 ± 1.6 versus 5.4 ± 1.8 days) between the groups (P < 0.001). The complication rate using transradial access was 2.03% (6/296) versus 6.0% (18/300) using transfemoral access (P < 0.0001). CONCLUSION: Transradial access for emergent percutaneous coronary intervention is safe and effective in patients with AMI, and it is suggested that this route could be used more widely in these patients.
Asunto(s)
Arteria Femoral , Infarto del Miocardio/cirugía , Evaluación de Resultado en la Atención de Salud , Intervención Coronaria Percutánea/métodos , Arteria Radial , Enfermedad Aguda , Anciano , China , Angiografía Coronaria , Femenino , Humanos , Masculino , Persona de Mediana Edad , Infarto del Miocardio/diagnóstico , Seguridad del Paciente , Intervención Coronaria Percutánea/efectos adversos , Sistema de Registros , Estudios RetrospectivosRESUMEN
Coronary artery anomalies (CAAs) are present at birth, but are usually asymptomatic and are found during coronary angiography or multi-slice computed tomography (MSCT) detection. The most common coronary anomaly is the separating origin of left anterior descending coronary artery (LAD) and left circumflex artery (LCX) from the left sinus of Valsalva, and this variant is benign. Herein, we present three extremely rare cases of anomalous right coronary artery (RCA) detected incidentally during routine coronary angiography and confirmed by multi-slice computed tomography (MSCT) technique. All the anomalous right coronary artery coursed between the pulmonary artery and aorta. We discuss how to make an accurate diagnosis for appropriate management.
Asunto(s)
Anomalías de los Vasos Coronarios/diagnóstico por imagen , Anciano , Aorta , Angiografía Coronaria , Femenino , Humanos , Hallazgos Incidentales , Masculino , Persona de Mediana Edad , Arteria Pulmonar/diagnóstico por imagen , Seno Aórtico/diagnóstico por imagen , Tomografía Computarizada por Rayos XRESUMEN
This case report we presented is that the anomalous left main coronary artery (LMCA) originates from the proximal segment of right coronary artery. In order to confirm the origin and course of the anomalous LMCA, a multi-slice computed tomography (MSCT) of the heart was performed on a 64-slice machine (Philips 64 Slice, Philips, USA) after 6 months of coronary angiography operation. The results showed that the anomalous LMCA originates from the proximal segment of right coronary artery, lies posteriorly to the aorta before taking acute sharply to go between the aorta and left atrium. It was classified as R-II P subtype according to Lipton's classification. It is a rare case in the clinical practice.
Asunto(s)
Anomalías de los Vasos Coronarios/diagnóstico , Vasos Coronarios/patología , Anciano , Humanos , MasculinoRESUMEN
The most common coronary anomaly is the left circumflex artery (LCX) arising from the proximal right coronary artery (RCA). This variant is benign. The anomalous RCA often originates from the left sinus or from the proximal of the left main coronary artery. This case report presents a single coronary artery that is the RCA originating from the mid left anterior descending artery. The case is rare. We discuss how to make a accurate diagnosis and how to administer appropriate treatment.
